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Norvir

Manufactured by Abbott
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Norvir is a pharmaceutical product manufactured by Abbott. It is a protease inhibitor medication used in the treatment of HIV infection. Norvir works by inhibiting the activity of HIV protease, an enzyme essential for the replication of the virus.

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Lab products found in correlation

Dmso hybri max, by Merck Group (1 mentions) Kaletra, by Abbott (1 mentions)

2 protocols using norvir

1

Oral Docetaxel and Ritonavir Pharmacokinetics

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In the clinical studies, docetaxel was administered to patients as drinking solution (iv formulation, Taxotere®, Rhone‐Poulenc Rorer/Aventis), capsules (ModraDoc001 10 mg capsules, Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute), or tablets (ModraDoc006 10 mg capsules, Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute). Ritonavir was administered as tablets (Norvir®; Abbott). Patients received orally 30 to 80 mg of docetaxel coadministered with ritonavir at a dose of 100 or 200 mg according to a weekly schema. Patients were fasted 2 hours before and 1 hour after oral drug administration to minimize variation in absorption.
Hendrikx J.J., Stuurman F.E., Song J., de Weger V.A., Lagas J.S., Rosing H., Beijnen J.H., Schinkel A.H., Schellens J.H, & Marchetti S. (2020). No relation between docetaxel administration route and high‐grade diarrhea incidence. Pharmacology Research & Perspectives, 8(4), e00633.
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2

Antiretroviral Drug Dissolution and Application

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APV and LPV for in-vitro experiments were purchased from Toronto Research Chemicals Inc (Ontario, Canada). Both antiretroviral drugs were dissolved in dimethyl sulfoxide (DMSO Hybri-Max; Sigma, Oakville, Ontario, Canada). FosAPV (oral Lexiva; ViiV Healthcare, Laval, Quebec, Canada), ritonavir (oral Norvir; Abbott Laboratories, Edmonton, Alberta, Canada) and LPV/ritonavir (oral Kaletra; Abbott Laboratories) were used for in-vivo studies.
Vivithanaporn P., Asahchop E.L., Acharjee S., Baker G.B, & Power C. (2016). HIV protease inhibitors disrupt astrocytic glutamate transporter function and neurobehavioral performance. AIDS (London, England), 30(4), 543-552.
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