Computed tomography (CT) measurements and magnetic resonance imaging (MRI) were obtained as clinically indicated. The clinical response was evaluated according to RECIST criteria v1.1 combined with a blinded medical judgment of benefits from the treatment. Additionally, whole body 18F-fluoro-2-deoxy-D-glucose-positron emission tomography (18FDG-PET) CT scans were performed as clinically indicated using a Siemens Biograph 6 True Point PET-CT (Siemens). A 350–450MBq 18F-FDG dose was administered 55–65 min before image acquisition. Reconstruction was performed using an iterative method and attenuation/scatter correction.
Biograph 6 true point pet ct
Manufactured by Siemens
Sourced in United States, Germany
The Biograph 6 True Point PET-CT is a medical imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to capture high-quality images of the body's metabolic and anatomical features simultaneously.
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4 protocols using biograph 6 true point pet ct
1
Imaging Evaluation of Treatment Response
2
PET/CT Imaging of Florbetapir Uptake
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Patients were imaged on either a Biograph 6 TruePoint PET/CT or a Biograph 64 mCT Flow (Siemens Medical Solutions USA, Inc.). Each subject was placed on the imaging table and injected with 10 mCi of 18F-Florbetapir 10–15 s after the start of listmode data acquisition. Image data were acquired at a single-bed position with the patient heart in the center of the field of view. PET data were acquired for 30 min based on findings from previous work (22 ). A low-dose CT (120 kVp, with variable mAs) was acquired for rough anatomical localization and attenuation and scatter correction. CT data were reconstructed using a 512 × 512 image matrix with 1.37 mm isotropic voxels and 5 mm slice thickness.
PET data were histogrammed into 35 frames for dynamic analysis (10 frames of 10 s each, 10 frames of 30 s each, 10 frames of 60 s each, 3 frames of 255 s each) as well as into single static sinograms for reconstruction. PET data were reconstructed using OSEM iterative reconstruction algorithms to reconstruct a 200 × 200 image matrix with 2.67 mm isotropic voxel and a 2 mm slice thickness. All PET data were reconstructed with point spread function resolution recovery (HD•PET, Siemens Medical Solutions USA, Inc.) applied.
A complete outline of the clinical protocol is provided in the Section3 .
PET data were histogrammed into 35 frames for dynamic analysis (10 frames of 10 s each, 10 frames of 30 s each, 10 frames of 60 s each, 3 frames of 255 s each) as well as into single static sinograms for reconstruction. PET data were reconstructed using OSEM iterative reconstruction algorithms to reconstruct a 200 × 200 image matrix with 2.67 mm isotropic voxel and a 2 mm slice thickness. All PET data were reconstructed with point spread function resolution recovery (HD•PET, Siemens Medical Solutions USA, Inc.) applied.
A complete outline of the clinical protocol is provided in the Section
3
Multimodal Imaging for Cancer Response
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Computed tomography (CT) measurements and magnetic resonance imaging (MRI) were obtained as clinically indicated. The clinical response was evaluated according to RECIST criteria v1.1 combined with a blinded medical judgment of benefits from the treatment. Additionally, whole body 18F-fluoro-2-deoxy-D-glucose-positron emission tomography (18FDG-PET)- CT scans were performed as clinically indicated using a Siemens Biograph 6 True Point PET-CT (Siemens). A 350-450MBq 18F-FDG dose was administered 55-65 min prior to image acquisition. Reconstruction was performed using an iterative method and attenuation/scatter correction.
4
Multimodal Imaging Protocol for Metabolic Assessment
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After a fasting period of at least 6 h and with the precondition of a blood glucose level below 130 mg/dl, the patients were intravenously injected with 3 MBq [18F] FDG per kilogram body weight and 20 mg furosemide for reduction of radiation exposure to the bladder wall. They were asked to stay in a semi-Fowler’s position in a quiet and darkened room for 60 min. [18F] FDG imaging was performed on an integrated PET/CT system (Biograph 6 TruePoint PET/CT, Siemens Medical Solutions, Erlangen, Germany). Contrast-enhanced CT images were initially obtained from the top of the skull to the proximal thighs (120 mAs, 130 kV, 4-mm slice collimation) followed by PET in 3D mode with an acquisition time of 3 min per bed position (axial FOV 16.2 cm). Images were reconstructed by an attenuation-weighted ordered-subsets expectation maximisation algorithm (four iterations, eight subsets) and a post-reconstruction smoothing Gaussian filter. The CT images in the chest were reconstructed in 4-mm-thick slices in order to provide an easier comparison with the DCE-MRI slices.
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