Chemicals, solvents, and reagents used for the syntheses were purchased from Sigma-Aldrich (St. Louis, MO), Fluka (Newport News, VA), or Alfa Aesar (Ward Hill, MA), and were used without any further purification. Column chromatography (CC): silica gel (Merck, Darmstadt, Germany). Mps: Büchi apparatus (Büchi, Flawil, Switzerland), uncorrected. 1H NMR and 13C NMR spectra: Varian Gemini-200 spectrometer (Varian Medical Systems (VAR), Palo Alto, CA); CDCl3; δ in ppm rel. to Me4Si as an internal standard; J in Hz. Elemental analyses were performed on a Carlo Erba EA-1110 CHNS-O instrument in the Microanalysis Laboratory of the Department of Pharmacy of Genoa University.
Ea 1110 chns o
Manufactured by Carlo Erba
The EA-1110 CHNS-O is an elemental analyzer designed for the determination of carbon, hydrogen, nitrogen, sulfur, and oxygen in a wide range of organic and inorganic materials. It provides accurate and precise analysis of these elements.
Automatically generated - may contain errors
3 protocols using ea 1110 chns o
1
Organic Synthesis Protocol Characterization
2
Spectroscopic Analysis of Pharmaceutical Compounds
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Melting points were taken in open glass capillaries on a Büchi apparatus and were uncorrected. Elemental analyses were performed on a Carlo Erba EA-1110 CHNS-O instrument in the Microanalysis Laboratory of the Department of Pharmaceutical Sciences of Genoa University. The analytical results are within ±0.4% of calculated values. 1H NMR and 13C NMR spectra (reported as supplemental material S1–S2 ) were recorded in CDCl3 or DMSO-d6 on Varian Gemini-200 spectrometer; d in ppm rel. to Me4Si as internal standard. J in Hz. Q = quinolizidine ring. Results of elemental analyses, thin-layer chromatography (TLC) and nuclear magnetic resonance (NMR) spectra indicated that the purity of all compounds was ≥95%.
Chemicals, solvents and commercially available intermediates were purchased from Aldrich (Milan). The non-commercially available intermediates were prepared according to the literature, or as follows, when not previously known.
Chemicals, solvents and commercially available intermediates were purchased from Aldrich (Milan). The non-commercially available intermediates were prepared according to the literature, or as follows, when not previously known.
3
Characterization of Organic Compounds
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Chemicals, solvents and reagents used for the syntheses were purchased from Sigma-Aldrich, Fluka or Alfa Aesar, and were used without any further purification. Column chromatography (CC):
neutral alumina (Al2O3), activity 1 (Merck). Mps: Büchi apparatus, uncorrected. 1 H NMR spectra:
Bruker Avance DPX-300 or Varian Gemini-200 spectrometers; CDCl3; in ppm rel. to Me4Si as internal standard. J in Hz. Elemental analyses were performed on a Carlo Erba EA-1110 CHNS-O instrument in the Microanalysis Laboratory of the Department of Pharmacy of Genoa University.
neutral alumina (Al2O3), activity 1 (Merck). Mps: Büchi apparatus, uncorrected. 1 H NMR spectra:
Bruker Avance DPX-300 or Varian Gemini-200 spectrometers; CDCl3; in ppm rel. to Me4Si as internal standard. J in Hz. Elemental analyses were performed on a Carlo Erba EA-1110 CHNS-O instrument in the Microanalysis Laboratory of the Department of Pharmacy of Genoa University.
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