Sodium phosphate

Fenofibrate (FENO) and naproxen (NAP), both micronized, were used as poorly water-soluble APIs (Novartis Pharma AG, Basel, Switzerland, kind gift from the manufacturer). Some general characteristics of the APIs are given in Table 1. All films were prepared with the HPMC Pharmacoat 606 (hydroxypropyl methyl cellulose; Shin-Etsu Chemical Eo., Tokyo, Japan; kind gift from Harke Pharma, Mülheim an der Ruhr, Germany) and the plasticizer glycerol (Roth, Karlsruhe, Germany). The lipid carrier systems consisted of tristearin as the solid lipid (Dynasan^® 118; HülsAG/Cremer Oleo, Witten, Germany; kind gift from the manufacturer) and medium chain triglycerides as liquid lipid (MCT; Miglyol^® 812, Caesar&Loretz, Hilden, Germany). For the stabilization of the various nanodispersions, the following additives were used: vinylpyrrolidone-vinyl acetate copolymers Kollidon^®VA 64 (KVA; BASF, Ludwigshafen, Germany), HPMC (Pharmacoat 606), sodium dodecyl sulphate (SDS; Roth, Karlsruhe, Germany). ODFs were prepared with distilled water and/or ethanol (purity 99.8 vol.%, Sigma-Aldrich, Taufkirchen, Germany). Sodium phosphate and hydrochloride acid (both Roth, Germany) as well as tetrahydrofuran (THF; Sigma-Aldrich, Taufkirchen, Germany) were used for characterization purposes.