4 acetamidophenol

Manufactured by Thermo Fisher Scientific

4-Acetamidophenol is a chemical compound used in various laboratory applications. It serves as a reagent and intermediate in organic synthesis. The product is available in powder form and meets standard purity requirements for use in research and development settings.

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Lab products found in correlation

Orion star a111 benchtop ph meter, by Thermo Fisher Scientific (1 mentions) Vacutainer, by BD (1 mentions)

2 protocols using 4 acetamidophenol

Acetaminophen Toxicity Induction Protocol

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For Acetaminophen (APAP) selection mice were fasted for approximately 16 h prior to acetaminophen administration. The mice received biweekly intraperitoneal injections of 13 mg/mL acetaminophen (4-Acetamidophenol, 98%, ACROS Organics) in saline⁵. APAP was dissolved in prewarmed saline and sterilized with a 0.2 μM filter prior to use. Doses of acetaminophen were started at 220 mg/kg in males and 250 mg/kg in females and increased by 5–10 mg/kg in subsequent doses until an elevated ALT (>800 IU/liter) response was observed. For analysis of an ALT response, blood was taken 6–7 h post APAP injection. Animals were monitored for potential adverse effects 6, 24, 48, and 72 h post APAP injection.

Tiyaboonchai A., Vonada A., Posey J., Pelz C., Wakefield L, & Grompe M. (2022). Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo. Nature Communications, 13, 7391.

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Acetaminophen Impacts on Calf Abomasal Health

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Calf BW was measured on arrival and on d 9. Acetaminophen (50 mg/kg; 4-acetamidophenol; ACROS Organics) was mixed into each OES on d 9 to indirectly assess AER. Jugular venous blood samples (6 mL potassium-citrate, Vacutainer, Becton, Dickinson and Company) were collected -0.5, 0, 1, 2, 3, 4, 6, and 8 h relative to the OES administration at 0700 h. Following centrifugation (1,500 × g for 15 min at 23°C), plasma was isolated and stored at -80°C for later analyses. Aseptic abomasal fluid sampling occurred at -0.5, 0, 1, 2, 4, and 6 h after OES supplementation. Volume and pH (Orion Star A111 pH Benchtop Meter, Thermo-Fisher Scientific) were measured immediately following collection. A sample from 6 h post-OES supplementation was immediately stored at -80°C for subsequent analysis of bacterial communities.

Kasl B.A., Machado V.S., Henniger M.T., Myer P.R, & Ballou M.A. (2022). Feeding an acetate-based oral electrolyte reduces the ex vivo Escherichia coli growth potential in the abomasum of calves fed oral electrolytes alone or 30 minutes following a milk feeding compared with feeding a bicarbonate-based oral electrolyte. Journal of dairy science, 105(2).

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