Haloperidol

Haloperidol was purchased from Tokyo Chemical Industry; acetaminophen and capsaicin from Nacalai Tesque; AM404 from Alomone Labs; methamphetamine from Sumitomo Dainippon Pharma; CNO from Cayman Chemical; DL-2-amino-5-phosphonopentanoic acid (DL-APV) from MilliporeSigma; dinitroquinoxaline-2,3(1H,4H)-dione (DNQX) from Tocris Bioscience (Bio-Techne); bicuculline from Enzo Life Science; and pentobarbital from Kyoritsu Seiyaku.
Haloperidol (1 mg/kg for rats, 2 mg/kg for mice) and acetaminophen (50 or 100 mg/kg for rats, 300 mg/kg for mice) were suspended in 0.5% carboxymethyl cellulose. AM404 was dissolved in 20% dimethyl sulfoxide (DMSO) and diluted with saline. capsaicin was dissolved in DMSO with 1% Tween 80 and diluted in saline (for rats) or 5% DMSO with 1% Tween 80 and diluted in saline (for mice). Methamphetamine was dissolved in saline prior to use. CNO was dissolved in 1% DMSO and diluted in saline for behavioral analysis or in artificial cerebrospinal fluid (ACSF) for electrophysiological analysis.

Haloperidol, sulpiride, risperidone, paliperidone, blonanserin and olanzapine were purchased from Tokyo Chemical Industry (Tokyo Japan). Dimethyl sulfoxide (DMSO) and tamoxifen citrate were purchased from FUJIFILM Wako Pure Chemical Corporation (Osaka, JAPAN). All drugs were dissolved in DMSO to a final DMSO concentration of 0.5%. The Cell Counting Kit-8 was purchased from Dojindo Molecular Technologies (Kumamoto, Japan).

Azilsartan, carvedilol, ciprofloxacin hydrochloride hydrate, dipyridamole, dantrolene sodium hydrate, furosemide, febuxostat, haloperidol, losartan potassium, lurasidone, montelukast sodium hydrate, and pioglitazone hydrochloride were purchased from Tokyo Chemical Industry Co., Ltd. Tamoxifen citrate and tosufloxacin tosylate hydrate were purchased from FUJIFILM Wako Pure Chemical Corporation. Raltegravir was extracted from the tablet. The manufacturers of the IR products are summarized in Table II.