The human population sample (n = 1419) was derived from participants in the baseline survey of the MIND-China,19 (link) a participating project of the World-Wide FINGERS Network.26 (link) AD was diagnosed according to the National Institute of Aging-Alzheimer's Association (NIA-AA) criteria,27 (link) for probable AD, as previously reported.28 (link) Multiple-PCR amplification analysis of genomic DNA was performed for participants to detect KIBRA gene Single Nucleotide Polymorphism (SNP) risk loci and exon region.29 Plasma total-tau, Aβ40, and Aβ42 levels were measured on a Simoa platform (Quanterix Corp, MA, USA) with Human Neurology 3-Plex A assay (N3PA), following the manufacturer's instructions.23 (link)
Human neurology 3 plex a assay
Manufactured by Quanterix
Sourced in United States
The Human Neurology 3-Plex A assay is a multiplex assay that measures three biomarkers related to neurological conditions. The assay is designed to quantify the levels of these biomarkers in biological samples. The core function of the assay is to provide accurate and reliable measurements of the selected biomarkers.
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Lab products found in correlation
2 protocols using human neurology 3 plex a assay
1
Alzheimer's Disease Biomarkers in Chinese
2
Quantification of Plasma Biomarkers
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After an overnight fast, peripheral blood samples were drawn into ethylene diamine tetraacetic acid (EDTA) citrate vacutainer tubes and centrifuged in a tabletop centrifuge. Plasma samples were then aliquoted and stored at −80°C until being retrieved and thawed on ice. Plasma biomarkers were measured using the single‐molecule array (Simoa) platform (Quanterix Corp, MA, USA) for Aβ42, Aβ40, and total tau (Human Neurology 3‐Plex A assay), and NfL (NF‐light advantage kit) at the laboratory of Wayen Biotechnologies Inc., Shanghai, China. Two quality control plasma samples were run in duplicate on each plate for each analyte. The intra‐assay coefficient of variation and the interassay coefficient of variation were all below 13.0% for the control sample.
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