Metformin hcl

Manufactured by Fagron

Sourced in Belgium, Spain

Metformin.HCl is a laboratory-grade chemical compound used in research and development applications. It is the hydrochloride salt of the biguanide drug metformin, which is commonly used to treat type 2 diabetes. As a laboratory reagent, Metformin.HCl can be utilized in various scientific experiments and analyses, but its specific applications are not detailed here.

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Lab products found in correlation

Acrylic acid, by Merck Group (1 mentions) Pepsin, by Merck Group (1 mentions) Sodium phosphate monobasic, by Thermo Fisher Scientific (1 mentions) Magnesium hydroxide, by Merck Group (1 mentions) Sodium taurocholate hydrate, by Merck Group (1 mentions)

2 protocols using metformin hcl

Synthesis and Characterization of Hydrophobic and Hydrophilic TPUs

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The hydrophobic TPU grade Tecoflex TM EG72D and the hydrophilic TPU grades Tecophilic TM SP60D60, SP93A100 and TG2000 were obtained from Merquinsa (a Lubrizol Company, Ohio, USA). As shown in Fig. 1, the hard segment (HS) of the hydrophobic and hydrophilic TPUs is a combination of hexamethylene diisocyanate (HMDI) and 1,4-butanediol (i.e. chain extender).
Although the hydrophobic and hydrophilic TPUs have a similar hard segment, the chemical composition of the soft segment (SS) is different. The soft segment of Tecophilic TM is PEO (polyethylene oxide), while the soft segment of Tecoflex TM is polytetrahydrofuran (pTHF).
4615 Metformin.HCl was purchased from Fagron (Waregem, Belgium).

Verstraete G., Mertens P., Grymonpré W., Van Bockstal P.J., De Beer T., Boone M.N., Van Hoorebeke L., Remon J.P, & Vervaet C. (2016). A comparative study between melt granulation/compression and hot melt extrusion/injection molding for the manufacturing of oral sustained release thermoplastic polyurethane matrices. International journal of pharmaceutics, 513(1-2).

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Metformin-based Gastric Tolerability Formulation

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Metformin HCl was purchased from Fagron Iberica (Barcelona, Spain). Sodium taurocholate hydrate, acrylic acid, N,N,N′,N′-tetramethylethylenediamine (TEMED), ammonium persulfate (PSA), magnesium hydroxide and pepsin from porcine gastric mucosa were provided from Sigma-Aldrich Spain (Madrid, Spain). Lecithin soy refined was supplied by MP Biomedicals (Illkirch, France). Sodium phosphate monobasic from Acros Organics (Geel, Belgium) and Blanose CMC 7LF were purchased from Ashland Chemical Hispania (Castellón, Spain). All other solvents and reagents (analytical grade) were purchased from Panreac Química (Barcelona, Spain) and utilized as supplied.

Simancas-Herbada R., Fernández-Carballido A., Aparicio-Blanco J., Slowing K., Rubio-Retama J., López-Cabarcos E, & Torres-Suárez A.I. (2020). Controlled Release of Highly Hydrophilic Drugs from Novel Poly(Magnesium Acrylate) Matrix Tablets. Pharmaceutics, 12(2), 174.

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