Symbia t6

Manufactured by Siemens

Sourced in Germany, United States

The Symbia T6 is a dual-head gamma camera system designed for nuclear medicine imaging. It combines SPECT (Single Photon Emission Computed Tomography) and CT (Computed Tomography) capabilities in a single integrated system. The core function of the Symbia T6 is to acquire and reconstruct high-quality images for diagnostic purposes.

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Lab products found in correlation

53 protocols using symbia t6

Post-Thyroidectomy Radioiodine Ablation Protocol

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All patients underwent initial ablation in the Department of Nuclear Medicine and Endocrinology, Paracelsus Medical University Salzburg, Austria after total or near-total thyroidectomy. Patients were instructed to follow a low-iodine diet for 2 weeks prior of the ablation RAI. Recombinant human thyroid stimulating hormone (rhTSH) was administered to all patients over two consecutive days (0.9 mg rhTSH -Thyrogen ® , Genzyme Europe B.V., Naarden, Netherlands -per day). A mean dose of 3661 ± 673 MBq I-131 (median 3617, range 1757-5956) was administered [Supplementary Material -▶ table 1S]. Post-treatment whole body scans were obtained 9 days after therapy in planar and SPECT/CT technique using a large field of view gamma camera (Symbia T6 or E-CAM; Siemens Medical Solutions, Erlangen, Germany) on a photo peak of 364 keV with a high-energy collimator.
SPECT/CT was performed on demand using the Symbia T6 (Siemens Medical Solutions, Erlangen, Germany) with 36 views á 45 s and Flash 3D (8 iterations, 4 subsets) for reconstruction. A low-dose CT (effective 30 mAs dose-modulated, 130 kV) was performed for anatomical correlation.

Rendl G., Rettenbacher L., Schweighofer-Zwink G., Hehenwarter L, & Pirich C. (2020). Pre-Ablation rhTSH-Stimulated F-18 FDG PET/CT Changes Patient Management in Increased-Risk Thyroid Cancer. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 52(3).

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SPECT Myocardial Perfusion Imaging Protocol

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All patients underwent ^99mTc‐MIBI rest gated MPI using SPECT with a dual‐head detector (Symbia T6; Siemens) with a low‐energy high‐resolution sensitivity collimator, energy peak 140 kev, window width 20%, matrix 64×64, and elliptical orbit 180°. One frame was acquired per 6° arc and for 30 s per one body position for a total of 30 frames. ^99mTc‐MIBI (740–925 MBq, 20–25 mCi) was administered intravenously, and after 30~60 min, 250 mL milk or fatty foods were taken to promote excretion of radioactive drugs from the liver. After 90 min, ^99mTc‐MIBI myocardial perfusion tomography was undertaken. Reconstruction was carried out using nonattenuation‐corrected filtered back projection (FBP) to generate the short‐axis, horizontal long‐axis, and vertical long‐axis views. All scanning data were randomly assigned to two cardiovascular radiologists with 20 years of clinical experience who were blind to the clinical data of the patients. A circular region of interest (ROI) was selected in the appropriate anatomic section of the right ventricle. Image J was used to determine mean voxel intensity of the target (right ventricle) and background (lung tissues adjacent to the right ventricle) and the target‐to‐background ratio (T/B) was calculated.

Wang Z., Li J., Wang X., Liu M., Liao M., Zhang C, & Shang X. (2021). Evaluation of pulmonary arterial pressure in patients with connective tissue disease‐associated pulmonary arterial hypertension by myocardial perfusion imaging. Annals of Noninvasive Electrocardiology, 27(2), e12927.

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Targeted SPECT Imaging of Melanoma

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SPECT imaging was conducted to observe the whole-body distribution of ¹³¹I-5-IPN in C57/BL6 mice bearing B16F10 melanoma and BALB/c nude mice bearing A375 melanoma using a human SPECT/computed tomography (CT) device (Symbia T6®, Siemens, Erlangen, Germany), with two high-energy collimators. The images were acquired by two parallel detectors rotating around the mouse for 32 projections, projection/5.6°. The acquisition was 20 s per projection with a matrix of 256 × 256 pixels focusing on the right shoulder region. A whole-body CT scan (100 mA, 130 kV, 1 mm section thickness) was acquired for subsequent SPECT/CT fusion (CapGM, Siemens syngo MI Workplace, Germany). All the models were injected with ¹³¹I-5-IPN (3.7 MBq, 100 μL) via tail vein. For blocking study, the C57/BL6 mice bearing B16F10 melanoma were pretreated with 1000-fold non-radioactive I-5-IPN (61.5 nmol, 21.4 μg) 30 min before administrating ¹³¹I-5-IPN.

Xu X., Yuan L., Gai Y., Liu Q., Yin L., Jiang Y., Wang Y., Zhang Y, & Lan X. (2018). Targeted radiotherapy of pigmented melanoma with 131I-5-IPN. Journal of Experimental & Clinical Cancer Research : CR, 37, 306.

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Quantifying Bone Metastasis Risk

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Whole-body bone scintigraphy images were acquired 4 h after intravenous injection of 740 MBq technetium-99m-methylene diphosphonate (Fujifilm RI Pharma) using a dual-head gamma camera equipped with low-to-mid-energy general-purpose collimators (Symbia T6; Siemens Medical Solutions, Malvern, PA, USA).
BONENAVI 2.0 (Fujifilm RI Pharma and EXINI Bone; EXINI Diagnostics, Lund, Sweden) was used to calculate the BSI, ANN, and HSn. Region-based ANNs in the range of 0.00 to 0.50 were expressed as blue spots, whereas those ranging from 0.51 to 1.00 were seen as red hotspots (Fig. 1). Based on the number of red areas, the software calculates the ANN to estimate the risk of bone metastasis (11 (link),12 (link)). BSI and HSn were monitored as an objective evaluation of the medical treatment (Fig. 1).

Nagano S., Nakamura S., Shimada H., Yokouchi M., Setoguchi T., Ishidou Y., Sasaki H, & Komiya S. (2016). Computer-assisted quantitative evaluation of bisphosphonate treatment for Paget's disease of bone using the bone scan index. Experimental and Therapeutic Medicine, 12(6), 3830-3836.

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Evaluation of Cerebral Perfusion Using SPECT

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SPECT, with technetium-99m hexamethylpropyleneamine oxime (^99mTc-HMPAO) as a radiotracer, was used for the evaluation of regional cerebral blood flow. Then, 740 MBq of radiotracer was administered in patients placed in a quiet, dimly lit room in supine position. Examinations were performed with SPECT/CT scan (Symbia T6, Siemens) on dual-head gamma camera with low-energy high-resolution parallel-hole collimator. Step and shoot acquisition mode was used, and sequences of 128 frames on a 128 × 128 matrix were obtained (64 projections per head, 30 s per projection). The photopeak was set at 140 keV with 10% window on either site of the photopeak. Iterative reconstruction (eight iterations, eight subsets, 7 mm Gauss filter), scatter correction, and CT attenuation correction were performed. Post-processing analysis was performed with Scenium software (Siemens Medical Solutions USA, Inc.). The regions of interest (ROIs) were predefined on a high-resolution T1 MRI volume scan. Perfusion in the basal ganglia, frontal lobes, hemispheres of cerebella, and thalami was subsequently examined among all patients. Values of variances from ROIs in individual parts of the frontal lobe on both sides (right and left separately) were taken for statistical analysis.

Alster P., Migda B., Madetko N., Duszyńska-Wąs K., Drzewińska A., Charzyńska I., Starczyński M., Szepelska A., Królicki L, & Friedman A. (2021). The Role of Frontal Assessment Battery and Frontal Lobe Single-Photon Emission Computed Tomography in the Differential Diagnosis of Progressive Supranuclear Palsy Variants and Corticobasal Syndrome—A Pilot Study. Frontiers in Neurology, 12, 630153.

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Technetium-99m HMPAO Brain SPECT/CT Protocol

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All of the mentioned patients were examined using SPECT with Technetium-99m HMPAO (99mTc-HMPAO) as a radiotracer.
All patients were placed in a quiet, dimly lit room in supine position. 740 MBq (0,02 Ci) of technetium-99m hexamethyl propylene amine oxime (^99mTc-HMPAO) was administered. All patients underwent brain SPECT/CT scan (Symbia T6, Siemens) on dual-head gamma camera with low energy high-resolution parallel-hole collimator. Step and shoot acquisition mode was used and sequences of 128 frames on a 128 × 128 matrix were obtained (64 projections per head, 30 seconds per projection). The photopeak was set at 140 keV with 10% window on either site of the photopeak. All images were reconstructed with filtered back projection and smoothed with a Butterworth filter. The reconstructed images were corrected for gamma-ray attenuation with measured correction matrix obtained from CT scan.

Alster P., Nieciecki M., Koziorowski D.M., Cacko A., Charzyńska I., Królicki L, & Friedman A. (2019). Thalamic and cerebellar hypoperfusion in single photon emission computed tomography may differentiate multiple system atrophy and progressive supranuclear palsy. Medicine, 98(30), e16603.

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99mTc-MIBI SPECT/CT Imaging Protocol

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^99mTc-MIBI scintigraphy was performed using a SPECT/CT scanner (Symbia T6, Siemens, Germany) after an intravenous injection of 740 MBq ^99mTc-MIBI. Early and late planar scans of the neck and mediastinum were acquired at 15 min and 120 min, respectively. The planar images were recorded in a 128 × 128 matrix with a 20% window at a 140 keV photopeak using a low-energy, high-resolution parallel collimator. An additional SPECT/CT acquisition was performed immediately after the late planar scan. The SPECT acquisition comprised 32 views of 20 s each. CT acquisition was performed with a slice thickness of 2.5 mm, a current of 240 mAs, and a voltage of 110 kV. The images were reconstructed in the transverse, coronal, and sagittal projections.

Jiang S.Q., Yang T., Zou Q., Xu L., Ye T., Kang Y.Q., Li W.R., Jiao J, & Zhang Y. (2020). The role of 99mTc-MIBI SPECT/CT in patients with secondary hyperparathyroidism: comparison with 99mTc-MIBI planar scintigraphy and ultrasonography. BMC Medical Imaging, 20, 115.

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Cardiac Imaging with PET/CT and SPECT/CT

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The FDG PET protocol has been described in detail elsewhere.^{13 (link)} Rest myocardial perfusion images were obtained using ⁸²Rubidium (~50 mCi) or ¹³N-ammonia (~20 mCi) PET/computed tomography (CT) (Discovery RX or DSTE Light Speed 64, GE Healthcare, Milwaukee, WI), or ^99mTc-sestamibi (~20 mCi) single-photon emission computed tomography (SPECT)/CT (Symbia T6, Siemens Healthcare, Hoffman Estates, Chicago, IL). After perfusion imaging, 10–12 mCi of ¹⁸F-fluorodeoxyglucose (FDG) was used to perform dedicated cardiac and whole body FDG PET/CT scans.
All patients were instructed to follow a high fat, very low carbohydrate diet (at least two meals) followed by a fast of at least four hours prior to the test to shift normal myocardial metabolism to primary fatty acid utilization and, therefore, suppress the uptake of FDG by normal myocardium.^{14 (link), 15 (link)}

Divakaran S., Stewart G.C., Lakdawala N.K., Padera R.F., Zhou W., Desai A.S., Givertz M.M., Mehra M.R., Kwong R.Y., Hedgire S.S., Ghoshhajra B.B., Taqueti V.R., Skali H., Dorbala S., Blankstein R, & Di Carli M.F. (2019). Diagnostic Accuracy of Advanced Imaging in Cardiac Sarcoidosis: An Imaging-Histologic Correlation Study in Patients Undergoing Cardiac Transplantation. Circulation. Cardiovascular imaging, 12(6), e008975.

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SPECT Imaging of VCAM-1 Expression

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Imaging studies were performed in the tumor-bearing mice using SPECT (Symbia T6, Siemens, Erlangen, Germany) with a 3.0 mm pinhole collimator. Briefly, under isoflurane anesthesia, after intravenous injection of ^99mTc-HYNIC-VCAM-1_scFv (7.4–11.1 MBq), images were acquired at 1, 2, and 4 h postinjection. For the blocking study, B16F10 tumor-bearing mice were given a 50-fold excess dose of unlabeled VCAM-1_scFv 1 h prior to the injection of ^99mTc-HYNIC-VCAM-1_scFv. The acquisition time was 10 min for each mouse.

Zhang X., Hu F., Liu C., Yin L., Zhang Y., Zhang Y, & Lan X. (2018). Evaluation of 99mTc-HYNIC-VCAM-1scFv as a Potential Qualitative and Semiquantitative Probe Targeting Various Tumors. Contrast Media & Molecular Imaging, 2018, 7832805.

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I-131 Whole-Body Scintigraphy and SPECT/CT

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All patients underwent a WBS I-131 and SPECT/CT with a hybrid camera, involving a combination of a dual-head c-camera with a spiral CT within the same gantry (Symbia T6: Siemens, Hoffman Estates, IL, USA). SPECT images were subjected to CT-based attenuation correction without scattered correction. The CT scan parameters were 130 keV, 30 mAs or less (for minimization of radiation exposure), a 512 × 512 matrix, and 2 mm × 2.5 mm collimation. I-131 accumulation higher than the background in at least one LM was defined as I-131 positive and that as low as the background in all LMs was defined as I-131 negative, based on visual evaluation.

Maruoka Y., Baba S., Isoda T., Kitamura Y., Abe K., Sasaki M, & Honda H. (2017). Association between Volumetric Analysis of Lung Metastases on F-18-fluoro-2-deoxy-D-glucose Positron Emission Tomography/Computed Tomography and Short-term Progression after I-131 Therapy for Differentiated Thyroid Carcinoma. Indian Journal of Nuclear Medicine : IJNM : The Official Journal of the Society of Nuclear Medicine, India, 32(3), 167-172.

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