VY-AADC01 volumetric coverage of the putamen was determined using iPlan Flow software (Brainlab AG) as previously described.2 (link) Gadoteridol-enhanced magnetic resonance (MR) images obtained at the end of infusion were compared with preinfusion MR images to determine the percentage of total putamen volume to which drug was administered. The overlap between pre- and postinfusion MR images was used to calculate percent coverage of each putamen, with total putamen coverage expressed as a single value representing the average across right and left putamen.
Iplan flow software
Manufactured by Brainlab
Sourced in Germany
IPlan Flow is a software tool developed by Brainlab for medical professionals. It is designed to assist with the planning and execution of surgical procedures. The software provides tools for visualizing and analyzing patient data, such as medical images, to support the decision-making process.
Automatically generated - may contain errors
Lab products found in correlation
3 protocols using iplan flow software
1
Quantifying Putamen Drug Coverage
2
Quantifying VY-AADC01 Distribution in Putamen
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Distribution of VY‐AADC01 within the putamen was analyzed using iPlan Flow software (Brainlab AG, Munich, Germany). Putamen segmentation was performed on a preadministration MRI acquisition (VPut) and gadoteridol enhancement volumetrically segmented on end‐of‐administration T1 volume MRI acquisitions (VGad). Volume of VY‐AADC01 distribution within each putamen (Vd) was generated by fusing the MRI images and calculating the intersection of VGad and VPut. VY‐AADC01 distribution across subjects was normalized and presented as percentage putamen coverage.
3
Multimodal Brain Imaging for Drug Infusion
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For the imaging analysis, volumetric 3D T1-weighted gradient echo brain MRI (slice thickness 1 mm, matrix 256 × 256, slice spacing 0.5 mm, FOV 22 cm) was performed within 14 days prior to catheter placement, as well as on postoperative day 1 after drug infusion. Data were acquired using a 3-T GE Signa scanner (GE Healthcare). PET/CT images of the brain performed within 1-6 hours after completion of drug infusion using a GE PET/CT scanner and MRI scans were imported into iPlan Flow software (Brainlab) and merged for analysis.
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