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Nonyl 4 hydroxyquinoline n oxide nqno

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Nonyl-4-hydroxyquinoline-N-oxide (NQNO) is a chemical compound used in laboratory research. It is a quinoline derivative with a nonyl group attached to the nitrogen atom. NQNO is a commonly used reagent, but a detailed description of its core function is not available without making interpretations or extrapolations.

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Lab products found in correlation

Pgp glo assay system, by Promega (1 mentions) Doxorubicin, by Merck Group (1 mentions) Ketoconazole, by Merck Group (1 mentions) Carbonyl cyanide 3 chlorophenylhydrazone, by Merck Group (1 mentions) Doxorubicin dx, by Merck Group (1 mentions) Verapamil, by Promega (1 mentions) Ketoconazole ke, by Merck Group (1 mentions)

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4-hydroxyquinoline (8 citations)

3 protocols using nonyl 4 hydroxyquinoline n oxide nqno

1

Pgp-Glo Assay: Compound Characterization

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The compounds used as the references: caffeine (CFN), carbonyl cyanide 3-chlorophenylhydrazone (CCCP), doxorubicin (DX), ketoconazole (KE), nonyl-4-hydroxyquinoline-N-oxide (NQNO), norfloxacin (NFX) and quinidine (QD) were obtained from Sigma-Aldrich (St. Louis, MO, USA). The references for Pgp activity studies: verapamil (VL) and Na3VO4 were provided with the luminescent Pgp-Glo™ Assay System (Promega, Madison, WI, USA).
Latacz G., Lubelska A., Jastrzębska-Więsek M., Partyka A., Marć M.A., Satała G., Wilczyńska D., Kotańska M., Więcek M., Kamińska K., Wesołowska A., Kieć-Kononowicz K, & Handzlik J. (2019). The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment. International Journal of Molecular Sciences, 20(14), 3420.
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2

Obtaining Pharmaceutical References for Research

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The compounds used as the references: caffeine (CFN), doxorubicin (DX), ketoconazole (KE) and nonyl-4-hydroxyquinoline-N-oxide (NQNO) were obtained from Sigma-Aldrich (St. Louis, MO, USA).
Sudoł S., Cios A., Jastrzębska-Więsek M., Honkisz-Orzechowska E., Mordyl B., Wilczyńska-Zawal N., Satała G., Kucwaj-Brysz K., Partyka A., Latacz G., Olejarz-Maciej A., Wesołowska A, & Handzlik J. (2021). The Phenoxyalkyltriazine Antagonists for 5-HT6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases. International Journal of Molecular Sciences, 22(19), 10773.
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3

Evaluation of Compound Pharmacokinetics

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The compounds used as the references—caffeine (CFN), doxorubicin (DX), ketoconazole (KE), nonyl-4-hydroxyquinoline-N-oxide (NQNO), norfloxacin (NFX), sulfaphenazole (SE), quinidine (QD) and warfarin (WFN)—were obtained from Sigma-Aldrich (St. Louis, MO, USA). The references for Pgp activity and pharmacokinetic studies—verapamil (VL) and Na3VO4—were provided with the luminescent Pgp-GloTM Assay System (Promega, Madison, WI, USA).
Lubelska A., Latacz G., Jastrzębska-Więsek M., Kotańska M., Kurczab R., Partyka A., Marć M.A., Wilczyńska D., Doroz-Płonka A., Łażewska D., Wesołowska A., Kieć-Kononowicz K, & Handzlik J. (2019). Are the Hydantoin-1,3,5-triazine 5-HT6R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro. Molecules, 24(24), 4472.
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