Avance 400 and 700

Manufactured by Bruker

Sourced in United States

The Avance 400 and 700 are high-performance nuclear magnetic resonance (NMR) spectrometers designed for advanced analytical applications. The Avance 400 operates at a frequency of 400 MHz, while the Avance 700 operates at a frequency of 700 MHz. These instruments provide researchers and analysts with powerful tools for the structural elucidation and characterization of various chemical compounds.

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Lab products found in correlation

Masslynx 4, by Waters Corporation (5 mentions) Synapt g2 si mass spectrometer, by Waters Corporation (5 mentions)

Close spelling variants of this product

Avance 400 (545 citations) Avance 700 (22 citations)

5 protocols using avance 400 and 700

Spectroscopic Characterization of Compounds

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¹H- and ¹³C-NMR spectra were recorded on the Bruker Avance 400 and 700 apparatus (TMS as an internal standard).
HRMS (high resolution mass spectrometry) measurements were made using a Synapt G2 Si mass spectrometer (Waters) equipped with an ESI source and a quadrupole time-of-flight mass analyzer. In order to achieve the highest accuracy of mass measurement, data was collected in center of gravity mode and the mass was corrected during the acquisition using enkephalin leucine solution as external reference (Lock-SprayTM) which generated reference ion at m/z 556.2771 Da ([M + H] ⁺) in positive ESI mode. The measurement results were processed with MassLynx 4.1 software (Waters).

Kupczyk D., Studzińska R., Baumgart S., Bilski R., Kosmalski T., Kołodziejska R, & Woźniak A. (2021). A Novel N-Tert-Butyl Derivatives of Pseudothiohydantoin as Potential Target in Anti-Cancer Therapy. Molecules, 26(9), 2612.

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NMR Spectroscopy and HRMS Analysis

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¹H- and ¹³C-NMR spectra (Figures S1A–J and S2A–I)—the Bruker Avance 400 and 700 apparatus (TMS as an internal standard).
HRMS (high-resolution mass spectrometry)-Synapt G2 Si mass spectrometer (Waters). The measurement results were processed with MassLynx 4.1 software (Waters) (Figure S3A–J).

Studzińska R., Kupczyk D., Płaziński W., Baumgart S., Bilski R., Paprocka R, & Kołodziejska R. (2021). Novel 2-(Adamantan-1-ylamino)Thiazol-4(5H)-One Derivatives and Their Inhibitory Activity towards 11β-HSD1—Synthesis, Molecular Docking and In Vitro Studies. International Journal of Molecular Sciences, 22(16), 8609.

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NMR and HRMS Analysis Protocols

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¹H- and ¹³C-NMR spectra were recorded on the Bruker Avance 400 and 700 apparatus (TMS as an internal standard, Bruker Billerica, Mass., USA)
High-resolution mass spectrometry (HRMS) measurements were performed using Synapt G2-Si mass spectrometer (Waters) equipped with an ESI source and quadrupole-Time-of-flight mass analyzer. To ensure accurate mass measurements, data were collected in centroid mode and mass was corrected during acquisition using leucine enkephalin solution as an external reference (Lock-SprayTM), which generated reference ion at m/z 556.2771 Da ([M + H]⁺) in positive ESI mode. The results of the measurements were processed using the MassLynx 4.1 software (Waters, Warsaw, Poland).

Kupczyk D., Studzińska R., Bilski R., Baumgart S., Kołodziejska R, & Woźniak A. (2020). Synthesis of Novel 2-(Isopropylamino)thiazol-4(5H)-one Derivatives and Their Inhibitory Activity of 11β-HSD1 and 11β-HSD2 in Aspect of Carcinogenesis Prevention. Molecules, 25(18), 4233.

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Microwave-Assisted Compound Characterization

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Microwave reactions were carried out using the MAGNUM V2 microwave reactor/mineralizer from ERTEC (Poland). ¹H- (Figures S1–S9) and ¹³C-NMR (Figures S10–S18)—spectra the Bruker Avance 400 and 700 apparatus (TMS as an internal standard, Bruker Billerica, MA, USA). HRMS (high-resolution mass spectrometry) (Figures S19–S27)—Synapt G2 Si mass spectrometer (Waters). The measurement results were processed with MassLynx 4.1 software (Waters, Warsaw, Poland).

Baumgart S., Kupczyk D., Archała A., Koszła O., Sołek P., Płaziński W., Płazińska A, & Studzińska R. (2023). Synthesis of Novel 2-(Cyclopentylamino)thiazol-4(5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory Activities. International Journal of Molecular Sciences, 24(8), 7252.

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NMR and HRMS Characterization Protocol

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¹H- and ¹³C-NMR spectra were recorded on the Bruker Avance 400 and 700 apparatus (TMS as an internal standard). High-resolution mass spectrometry (HRMS) measurements were made using a Synapt G2 Si mass spectrometer (Waters) equipped with an ESI source and a quadrupole time-of-flight mass analyzer. In order to achieve the highest accuracy of mass measurement, data were collected in center of gravity mode and the mass was corrected during acquisition using enkephalin leucine solution as external reference (Lock-SprayTM), which generated reference ion at m/z 556.2771 Da ([M + H]⁺) in positive ESI mode. The measurement results were processed with MassLynx 4.1 software (Waters).

Kosmalski T., Hetmann A., Studzińska R., Baumgart S., Kupczyk D, & Roszek K. (2022). The Oxime Ethers with Heterocyclic, Alicyclic and Aromatic Moiety as Potential Anti-Cancer Agents. Molecules, 27(4), 1374.

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