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Cobas integra 400 800 analyzer

Manufactured by Roche
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The Cobas Integra 400/800 analyzer is a clinical chemistry and immunochemistry system designed for routine laboratory testing. It provides automated analysis of a wide range of analytes from various sample types. The system combines high-throughput performance with reliable results, ensuring efficient laboratory workflow.

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Lab products found in correlation

Eclipse 80i, by Nikon (2 mentions) Nis elements br software, by Nikon (2 mentions) Digital sight ds fi1, by Nikon (2 mentions) Shandon cryotome e, by Thermo Fisher Scientific (2 mentions)

Spelling variants of this product

Cobas Integra 400 (222 citations) Cobas Integra 800 (178 citations) Cobas Integra (65 citations) Integra 800 (30 citations) Integra 400 (27 citations) Cobas Integra analyzer (21 citations) Cobas 800 (18 citations) Roche/Integra 400 Analyzer (17 citations) Cobas 400 (12 citations) Cobas integra 400/800 (6 citations)

3 protocols using cobas integra 400 800 analyzer

1

Vancomycin Dosing and Therapeutic Drug Monitoring

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Vancomycin was given as a 60 min infusion at the dose recommended in Neofax (Table 1) [19 ]. Individual dose adjustments based on the TDM results were performed at the discretion of the treating physician. Start and termination of vancomycin therapy, dosing regimen and infusion time prior to TDM sample and TDM sampling time were collected.

Vancomycin dosing regimen as recommended by Neofax 2010 and used in this study

PMA (week)PNA (day)Interval (hour)Daily dose (mg/kg/24 h)
≤290–141813
>141220
30–360–141220
>14830
37–440–71220
>7830
≥45all640
In our hospital vancomycin TDM samples are routinely taken an hour before the 3rd or 4th dose and thereafter at the discretion of the treating physician. Vancomycin concentrations were measured by commercial fluorescence polarization immunoassay according to manufacturers’ instructions (Cobas Integra 400/800 Analyzer, Roche, Mannheim, Germany). TDM samples taken up to 2 h before the next dose were designated Ctroughs.
Padari H., Oselin K., Tasa T., Metsvaht T., Lõivukene K, & Lutsar I. (2016). Coagulase negative staphylococcal sepsis in neonates: do we need to adapt vancomycin dose or target?. BMC Pediatrics, 16, 206.
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2

Histological and Biochemical Analysis of Muscle Fiber

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Serial sections of 12 μm thickness were cut from the mid-belly region of diaphragm and tibialis anterior (TA) muscles on a refrigerated cryostat (Shandon Cryotome E, Thermo) at −20°C. Sections were stained with hematoxylin and eosin (H&E) and Masson’sTrichrome. Digitized images (8 bit) of muscle sections were acquired with a CCD camera (Digital Sight DSFi1, Nikon) attached to an upright microscope (Nikon Eclipse 80i). Images were analyzed with NIS Elements Br software (Nikon) where the mean cross sectional area (CSA) of muscle fibers was calculated by interactive determination of the circumference of at least 200 adjacent cells from the center of every muscle section examined. Percentage of central nuclei was determined from at least 200 fibers from at least 3 mice of each genotype. For serum creatine kinase (CK) activity blood was drawn from the saphenous vein, serum separated and CK activity measured on a Cobas Integra 400/800 analyzer (Roche).
Pal R., Palmieri M., Loehr J.A., Li S., Abo-Zahrah R., Monroe T.O., Thakur P.B., Sardiello M, & Rodney G.G. (2014). Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy. Nature communications, 5, 4425.
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3

Histological and Biochemical Analysis of Muscle Fiber

Check if the same lab product or an alternative is used in the 5 most similar protocols
Serial sections of 12 μm thickness were cut from the mid-belly region of diaphragm and tibialis anterior (TA) muscles on a refrigerated cryostat (Shandon Cryotome E, Thermo) at −20°C. Sections were stained with hematoxylin and eosin (H&E) and Masson’sTrichrome. Digitized images (8 bit) of muscle sections were acquired with a CCD camera (Digital Sight DSFi1, Nikon) attached to an upright microscope (Nikon Eclipse 80i). Images were analyzed with NIS Elements Br software (Nikon) where the mean cross sectional area (CSA) of muscle fibers was calculated by interactive determination of the circumference of at least 200 adjacent cells from the center of every muscle section examined. Percentage of central nuclei was determined from at least 200 fibers from at least 3 mice of each genotype. For serum creatine kinase (CK) activity blood was drawn from the saphenous vein, serum separated and CK activity measured on a Cobas Integra 400/800 analyzer (Roche).
Pal R., Palmieri M., Loehr J.A., Li S., Abo-Zahrah R., Monroe T.O., Thakur P.B., Sardiello M, & Rodney G.G. (2014). Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy. Nature communications, 5, 4425.
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