Norcocaine

Manufactured by Lipomed

Sourced in Switzerland

Norcocaine is a chemical compound used in laboratory settings. It serves as a standard reference material for the identification and quantification of cocaine and its metabolites in analytical testing procedures.

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Lab products found in correlation

3 protocols using norcocaine

Radioligand Binding Assay Protocol

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[³H]-Clonidine (61.3 Ci/mmol) was purchased from Perkin Elmer (Courtaboeuf, France). Specs compounds (AE; AF; AG; AI; AK; AN; AO; AP) were purchased from Specs (Delft, The Netherlands). 6-monoacetylmorphine, codeine, cocaethylene, norcocaine, desomorphine, dihydromorphine, hydrocodone, hydromorphone, norbuprenorphine, oxycodone, and oxymorphone were obtained from Lipomed (Euromedex, Souffelweyersheim, France) and heroin, methadone, and morphine from Francopia (Paris, France). Methylenedioxy-methylamphetamine (MDMA, ecstasy) was synthetized by Dr H. Galons from the chemistry department of Paris University. All other chemicals were purchased from Sigma (St Quentin Fallavier, France) except diphenhydramine (Inresa, Strasbourg, France), cocaine (Cooper, Melun, France), and D617 (Carbosynth, Campton, UK).

Smirnova M., Goracci L., Cruciani G., Federici L., Declèves X., Chapy H, & Cisternino S. (2022). Pharmacophore-Based Discovery of Substrates of a Novel Drug/Proton-Antiporter in the Human Brain Endothelial hCMEC/D3 Cell Line. Pharmaceutics, 14(2), 255.

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Simultaneous LCMS Analysis of Psychoactive Drugs

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Standard solutions of the analytes alprazolam (ALP), citalopram (CIT), diazepam (DIAZ), doxepin (DOX), flunitrazepam (FLUN), fluoxetine (FLUOX), carbamazepine (CARB), cocaethylene (COCET), cocaine (COC), norcocaine (NORCOC), nordiazepam (NORDIAZ), nortriptyline (NORTR), oxazepam (OXA), temazepam (TEM), and venlafaxine (VEN) were purchased from Lipomed AG (Arlesheim, Switzerland). Deuterated derivatives of the analytes alprazolam-d5, diazepam-d5, flunitrazepam-d3, fluoxetine-d6, carbamazepine-d10, nordiazepam-d5, oxazepam-d5, and temazepam-d5, used as internal standards, were also purchased from Lipomed AG (Arlesheim, Switzerland). The selected number of 15 analytes, including six metabolites, was considered sufficient given that it was a preliminary study, and increasing the complexity of the method could potentially cause selectivity problems.
High-purity LC-MS chromatographic solvents acetonitrile, methanol, isopropyl alcohol, and sodium hydroxide obtained from Fluka Analytical (Seelze, Germany) were used in the experiment. Analytical-grade solvents acetonitrile, methanol, isopropyl alcohol, sodium hydroxide, and ammonium formate from Sigma-Aldrich (St. Louis, MO, USA) and formic acid obtained from Merck (Darmstadt, Germany) were also used. Deionized ultrapure water (18.2 M Ω · cm, TOC < 5 ppb) was obtained with the Milli-Q Plus system (Millipore, Bedford, MA, USA).

Wójtowicz A., Reciak M., Nowak P.M, & Wietecha-Posłuszny R. (2022). A sustainable approach for the stability study of psychotropic substances using vitreous humor and liver as alternative matrices. Analytical and Bioanalytical Chemistry, 414(21), 6355-6370.

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3D Printed Extraction Device for Forensic Analysis

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Chemicals LC-MS grade water was purchased from Huberlab (Aesch, Switzerland); methanol was purchased from VWR (Darmstadt, Germany); formic acid was purchased from Sigma-Aldrich (Buchs, Switzerland). Benzoylecgonine, norcocaine, cocaine, cocaine-d3, methylecgonine, cocaethanol, tramadol, O-desmethyltramadol, and N-desmethyltramadol were purchased from Lipomed AG (Arlesheim, Switzerland). A pool of human urine was made using nine anonymous donors and was stored at -20 °C prior to analysis.
Computer-aided design and 3D printing 3DP-OPP and other models were designed in Autodesk Fusion360 software (San Rafael, USA). Source files in .stl format containing various parts are available in the ESI. † A FormLabs Form 2 SLA printer (Artsupport GmbH, RümLang, Switzerland) was used for printing a 3DP-OPP with High Temp resin due to its compatibility with methanol and a printing liquid handler tool with Clear resin because it is more flexible and resistant to impact. The model was oriented at 45°t owards the table and sliced at 0.05 mm resolution using the PreForm software (FormLabs, Somerville, USA). The density of the supports was set to 0.60 and the point size was set to 0.50 mm. An X400CE FDM printer and PLA filament (German RepRap GmbH, Feldkirchen, Germany) were used for printing other parts.

Sosnowski P., Marin V., Tian X, & Hopfgartner G. (2022). Analysis of illicit pills and drugs of abuse in urine samples using a 3D-printed open port probe hyphenated with differential mobility spectrometry-mass spectrometry. The Analyst, 147(19).

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