Glycolic acid

Manufactured by Fujifilm

Glycolic acid is a colorless, crystalline compound commonly used in various laboratory applications. It is a type of alpha-hydroxy acid (AHA) known for its ability to facilitate chemical reactions and processes. Glycolic acid has a range of functional properties that make it a versatile tool in laboratory settings.

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Lab products found in correlation

Hydrogen peroxide, by Fujifilm (1 mentions) Formic acid, by Fujifilm (1 mentions) D mannose, by Fujifilm (1 mentions) Benzoic acid, by Fujifilm (1 mentions) Mg no3 2, by Fujifilm (1 mentions) Al no3 3, by Fujifilm (1 mentions) D fructose, by Fujifilm (1 mentions) D xylose, by Fujifilm (1 mentions)

2 protocols using glycolic acid

Catalytic valorization of biomass-derived compounds

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d(+)‐glucose (98 %, Kishida), d(−)‐fructose (99 %, Wako), d(+)‐mannose (99 %, Wako), d(+)‐xylose (99 %, Wako), dl‐glycelaldehyde (>90 %, Sigma‐Aldrich), glycolic acid (97 %, Wako), formic acid (98 %, Wako), hydrogen peroxide (30 %, Wako), and benzoic acid (99.5 %, Wako) were used for the reactions and the analysis. Calcium oxide (CaO, 99.9 %, Wako), hydroxide (Ca(OH)₂, 90 %, Kishida), carbonate (CaCO₃, 99.95 %, Wako), and phosphate (Ca₃(PO₄)₂, 98 %, Wako) were used as catalysts. Other metal oxides, MgO (99.9 %, Wako), SrO (95 %, Kishida), BaO (90 %, Wako), Sc₂O₃ (99.9 %, Kojundo), Y₂O₃ (99.99 %, Wako), La₂O₃ (99.99 %, Wako), CeO₂ (99.9 %, Wako), TiO₂ (anatase, 98.5 %, Wako), Nb₂O₅ (99.9 %, Kojundo), Ta₂O₅ (99.9 %, Wako), Cr₂O₃ (Wako), SnO₂ (98 %, Wako) and ZnO (99.9 %, Wako) were also used as catalysts. Mg‐Al hydrotalcite (Mg/Al=3) was prepared by a conventional coprecipitation method^[39] using Mg(NO₃)₂ ⋅ 6H₂O (99 %, Wako), Al(NO₃)₃ ⋅ 9H₂O (98 %, Wako), Na₂CO₃ (99.5 %, Kishida) and NaOH (98 %, Kishida).

Takagaki A., Obata W, & Ishihara T. (2021). Oxidative Conversion of Glucose to Formic Acid as a Renewable Hydrogen Source Using an Abundant Solid Base Catalyst. ChemistryOpen, 10(10), 954-959.

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Evaluation of Irritation and Toxicity

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We evaluated irritation based on the protocol for the STE test, as previously described (Takahashi et al., 2008 (link)). We selected glycolic acid (Wako; cat. no 071-01512) as a positive chemical for the irritant test. Briefly, primary cells or K4DT + T cells in six-well plates were exposed to either a 0.5% or 5% glycolic acid solution for 5 min; PBS was used as a negative control. Furthermore, we also tested the toxicity of Benzalkonium chloride. The cells in each well were washed twice with PBS and then treated with Accutase for 5 min. The total number of cells and the cell viability were determined using trypan blue staining. To avoid bias in cell counting, an automatic cell counter was used for all measurements. Cell viability was calculated based on the ratio of the number of living cells relative to the total cell number.

Fukuda T., Gouko R., Eitsuka T., Suzuki R., Takahashi K., Nakagawa K., Sugano E., Tomita H, & Kiyono T. (2019). Human-Derived Corneal Epithelial Cells Expressing Cell Cycle Regulators as a New Resource for in vitro Ocular Toxicity Testing. Frontiers in Genetics, 10, 587.

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