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α hydroxymetoprolol

Manufactured by LGC
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Sourced in Canada, China

α-hydroxymetoprolol is a laboratory reagent used in analytical chemistry and biomedical research. It is a metabolite of the drug metoprolol and is commonly used as an analytical standard or reference material in the development and validation of analytical methods.

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Lab products found in correlation

Paraxanthine, by Merck Group (1 mentions) Metoprolol, by Merck Group (1 mentions) Omeprazole, by LGC (1 mentions) Losartan, by LGC (1 mentions) Fluconazole, by LGC (1 mentions) Efavirenz, by Merck Group (1 mentions) Midazolam d6, by Lipomed (1 mentions) Caffeine d9, by LGC (1 mentions) Metoprolol d7, by LGC (1 mentions) High performance liquid chromatography grade methanol, by Merck Group (1 mentions) 8 hydroxyefavirenz, by LGC (1 mentions) 8 14 dihydroxyefavirenz, by LGC (1 mentions) 5 hydroxy omeprazole, by LGC (1 mentions) 1 hydroxymidazolam, by Lipomed (1 mentions) β glucuronidase, by Merck Group (1 mentions) Midazolam, by Roche (1 mentions) Formic acid, by Merck Group (1 mentions) Milli q plus system, by Merck Group (1 mentions) 1 hydroxymidazolam, by Cayman Chemical (1 mentions) 6 hydroxychlorzoxazone, by LGC (1 mentions)

2 protocols using α hydroxymetoprolol

1

Quantitative Bioanalysis of Pharmaceutical Compounds

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Caffeine-d9, ciprofloxacin, efavirenz-d4, 8-hydroxyefavirenz, 8,14-dihydroxyefavirenz, fluconazole, losartan, losartan carboxylic acid (E3174), losartan-d4, α-hydroxyMetoprolol, Metoprolol-d7, omeprazole, 5-hydroxyomeprazole, omeprazole-d3, paroxetine, and rifampicin were purchased from Toronto Research Chemicals (Toronto, Canada). 1’-HydroxyMidazolam and Midazolam-d6 were purchased from Lipomed (Lipomed AG, Arlesheim, Switzerland). Metoprolol, paraxanthine, and β-glucuronidase were obtained from Sigma-Aldrich (Sigma-Aldrich Chemie GmbH, Buchs, Switzerland). Midazolam (Hoffmann-La Roche, Basel, Switzerland) and efavirenz (Merck, NJ, USA) were kindly provided by the producers.
Formic acid, high-performance liquid chromatography (HPLC)-grade methanol, and water were purchased from Merck (Merck, Darmstadt, Germany). Stock solutions, calibration spiking solutions, and quality controls were prepared in dimethyl sulfoxide. Calibration standards were prepared by enriching caffeine-free blank human serum using the corresponding spiking solutions. Internal standard solutions containing the deuterated compounds were prepared in methanol.
Derungs A., Donzelli M., Berger B., Noppen C., Krähenbühl S, & Haschke M. (2015). Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study. Clinical Pharmacokinetics, 55, 79-91.
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2

Quantitative LC-MS/MS Bioanalysis

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Phenacetin (99.9%, T0778), acetaminophen (99.9%, T0065), tolbutamide (99.7%, T1054), metoprolol (99.8%, T0487), and chlorzoxazone (99.7%, T1650) were purchased from Target Molecule Corp. (Massachusetts, USA); omeprazole (> 99%, MB1692-S) from Dalian Meilun Biotech Co., Ltd. (Dalian, China); midazolam (5 mg/mL, H10980025) from Jiangsu Enhua Pharmaceutical Co., Ltd. (Xuzhou, China); 4 -hydroxytolbutamide (100%, H969850), 5 -hydroxyomepreole (95%, H948110), α -hydroxymetoprolol (100%, H948390), and 6 -hydroxychlorzoxazone (100%, H825120) from Toronto Research Chemicals (Toronto, Canada); 1hydroxymidazolam (95%, 10385-1) from Cayman Chemicals (Michigan, USA); and lamotrigine (100775-200401) from National Institutes for Food and Drug Control (Beijing, China). Glycyrrhetic acid (> 98%, B20412) was obtained from Yuanye Biotechnology Co., Ltd. (Shanghai, China) and used as internal standard (IS). HPLC-grade acetonitrile and methanol were purchased from Merck Company (Darmstadt, Germany); formic acid from CNW Technologies (Dusseldorf, Germany); phosphate buffer saline from Beijing Solarbio Science & Technology Co., Ltd. (Beijing, China); ReadiUse NADPH Regenerating Kit from Wuhan PrimeTox Bio-pharma Technology Co., Ltd. (Wuhan, China); and deionized water from a Millipore Milli-Q Plus system (Bedford, USA).
Guo J., Xu Y., Chen L., Zhang S., Rao T., Peng J., Guo Y., Tan Z., Ouyang D., Chen X., Liou Y., Zhang W., & Chen Y. (2021). Gut Microbiota and Host Cyp450s Co-contribute to Pharmacokinetic Variability in Mice With Non-Alcoholic Steatohepatitis: Vary From Drug to Drug.
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