SPECT/CT scans were acquired with a Siemens Symbia T16 scanner at 96 and 168 h post-injection (p.i.) in arm 1 and at 24, 96, and 168 h p.i. in arms 2, 3, 4, and 5 (Fig. 2 ). The criteria for dosimetry to be performed included the ability to visually differentiate volume on low-dose CT and activity on SPECT, as well as a minimum volume of 1.5 mL. Two individual volume of interests (VOIs) were defined for each tumor, mass VOI delineated on low-dose CT and activity VOI delineated on SPECT, both drawn manually slice by slice by an experienced nuclear medicine specialist [19 (link)]. The masses derived from the CT VOIs were used for dose calculations, and the time activity curves based on uptake values at all time points was used to determine tumor-absorbed doses as described previously [19 (link)].
Symbia t16 scanner
Manufactured by Siemens
Sourced in Germany
The Symbia T16 scanner is a nuclear medicine imaging system developed by Siemens. It is designed to capture high-quality images of the body's internal structures and functions. The Symbia T16 scanner combines single-photon emission computed tomography (SPECT) and computed tomography (CT) technologies to provide comprehensive diagnostic information.
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3 protocols using symbia t16 scanner
1
Tumor Dosimetry from SPECT/CT Scans
2
Quantifying Tumor Uptake with 177Lu-Lilotomab Satetraxetan
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In brief, attenuation and scatter-corrected SPECT/CT images were acquired with a Siemens Symbia T16 scanner (Siemens Healthineers, Erlangen, Germany) at 96 and 168 h post injection (p.i.) of 177Lu-lilotomab satetraxetan. As from arm 2, an additional scan 24 h p.i. was performed. The acquisition covered areas of known lesions, and for at least three patients in each arm, the thorax and abdomen areas were also covered. Planar scintigraphy scans were acquired approximately 2, 24, 96, and 168 h p.i. The acquisition parameters and the methodological considerations have been described previously [8 ].
3
Dual-Phase Planar Static Imaging with 99mTc-MIBI
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was obtained from a commercial 99Mo/99mTc generator (Beijing Atom High Tech Co. Ltd, Beijing, China). MIBI was obtained from the Jiangsu Atom Medicine Research Institute, Jiangyuan Pharmaceutical Factory (Wuxi, China). Labeling was performed according to the manufacturer’s instructions. Labeling efficiency was more than 95%. Overall, 740–1110 MBq (20–30 mCi) 99mTc-MIBI was injected intravenously into all HPT patients. After 15 min, dual-phase planar static imaging of the cervical and thoracic area in the anterior view was performed (early phase) using a large-field gamma camera (Siemens, Erlangen, Germany) with a low-energy high-resolution collimator, a 20% energy window centered at a 140-keV photopeak, a 128×128 matrix size, a 1.45 zoom factor, and 500 k counts/view. The delayed phase was performed 120 min after the 99mTc-MIBI injection. SPECT/CT fusion tomography was performed 30 min after the 99mTc-MIBI injection using a Symbia T16 scanner (Siemens, Erlangen, Germany).
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