Hypoxanthine

Calcium chloride dihydrate (CaCl2·2H2O), hydrogen peroxide (H2O2, 30 wt.%) and ammonia solution (NH3·H2O, 25~28 wt.%) were purchased from Aladdin Chemistry Co. Ltd (Shanghai, China). Polyvinylpyrrolidon (PVP, K88-96, Mw = 1300 kDa and K30, Mw = 58kDa), polyvinyl alcohol (PVA, 1788 type, alcoholysis = 87.0-89.0%), carboxymethyl cellulose (CMC, Mw = 90,000), urate oxidase (UOx, ≥20 U/mg), allopurinol (AP), potassium oxonate (PO) and hypoxanthine (HPT) were provided by Macklin Biochemical Co., Ltd (Shanghai, China). Assay kits for serum uric acid (UA), serum creatinine (SCr), blood urea nitrogen (BUN), xanthine oxidase (XOD), and adenosine deaminase (ADA) activity were obtained from Elabscience Biotechnology Co., Ltd (Wuhan, China). CaO2 nanoparticles (NPs) were synthesized based on a previously reported method [33] .

Polyvinylpyrrolidone (PVP MW = 58 KDa), polycaprolactone (PCL MW = 45 KDa), polyvinyl alcohol (PVA, 1788 type, alcoholysis= 87.0-89.0%), potassium oxonate (98%, MW =195.18) and hypoxanthine (99%) were purchased from Macklin Biochemical Co., Ltd.
(Shanghai, China). Allopurinol (AP, 98%) and rhodamine 6G (R6G) were obtained from Aladdin Chemistry Co. Ltd. (Shanghai, China). Serum uric acid (UA)(Art. No. E-BC-K016-M), serum creatinine (SCr) (Art. No. E-BC-K188-M), nitric oxide (NO) colorimetric assay kit(Art. No. E-BC-K035-M) and adenosine deaminase (ADA) activity assay kit (Art. No. E-BC-K197-M) were obtained from Elabscience Biotechnology Co., Ltd. (Wuhan, China). Strat-M membranes with a diameter of 25 mm and thickness of 300 μm were purchased from Shanghai Xuanyi Environmental Protection Technology Co., Ltd. (Shanghai, China).