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Diltiazem hydrochloride

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Diltiazem hydrochloride is a calcium channel blocker compound used in various laboratory applications. It functions by inhibiting the movement of calcium ions into the muscle cells of the heart and blood vessels, which can affect cardiovascular processes. The specific details and intended uses of this product should be obtained from the product documentation or by consulting with a technical specialist.

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Lab products found in correlation

L name, by Merck Group (2 mentions) Nembutal, by Sanofi (2 mentions) Cell culture media, by Thermo Fisher Scientific (1 mentions) 4 methylumbelliferyl β d glucopyranoside mug, by Merck Group (1 mentions) Conduritol b epoxide, by LGC (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Naloxone hydrochloride, by Bio-Techne (1 mentions) Methadone hydrochloride, by Merck Group (1 mentions) Phenylephrine hydrochloride, by Merck Group (1 mentions) Diethylamine nonoate, by Merck Group (1 mentions)

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Diltiazem (6 citations)

4 protocols using diltiazem hydrochloride

1

Fluorescent Glucoside Assay Protocol

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4-Methylumbelliferyl β-D-glucopyranoside (MUG) was from Sigma (St. Louis, MO). Conduritol B epoxide (CBE) was from Toronto Research Chemicals (Downsview, ON, Canada). Diltiazem hydrochloride was from Tocris Bioscience (Ellisville, MO). Cell culture media were purchased from Gibco (Grand Island, NY).
Tan Y.L., Genereux J.C., Pankow S., Aerts J.M., Yates JR I.I.I, & Kelly J.W. (2014). ERdj3 is an Endoplasmic Reticulum Degradation Factor for Mutant Glucocerebrosidase Variants Linked to Gaucher’s Disease. Chemistry & biology, 21(8), 967-976.
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2

Characterization of Pharmaceutical Compounds

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Naloxone hydrochloride (0599), tolterodine L-tartrate (3761), and diltiazem hydrochloride (0685) were purchased from Tocris Bioscience. Buprenorphine hydrochloride (B9275, USDEA C-III), (±)-methadone hydrochloride (M0267, USDEA C-II), naltrexone hydrochloride (N3136), (±)-verapamil hydrochloride (V4629), and DMSO (D8418) were purchased from Sigma-Aldrich. Norbuprenorphine hydrochloride (USDEA C-II) was purchased from Noramco. Stock solutions of naloxone, naltrexone, and verapamil were dissolved in milliQ water. Stock solutions of methadone, buprenorphine, norbuprenorphine, diltiazem, and tolterodine were dissolved in DMSO. When DMSO was used as a solvent, the % of DMSO exposed to cells was ≤0.3%. Aliquoted stock solutions were stored at -20°C until the day of experiments and were diluted to specific test concentrations in the external solution.
Ren M., Randolph A.L., Alvarez-Baron C., Guo D., Tran P.N., Thiebaud N., Sheng J., Zhao J, & Wu W.W. (2022). Experimental factors that impact CaV1.2 channel pharmacology—Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the “step-step-ramp” voltage protocol. PLOS ONE, 17(11), e0276995.
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3

Vasodilation and Anesthetic Protocols

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Sodium pentobarbital (Nembutal®) was obtained from Sanofi (Brussels, Belgium), indomethacin from Federa (Belgium), L-NAME, phenylephrine hydrochloride (PE) and diethylamine NONOate (DEANO) from Sigma-Aldrich (Bornem, Belgium), diltiazem hydrochloride from TOCRIS (Bristol, United Kingdom).
Leloup A.J.A., Van Hove C.E., De Moudt S., De Keulenaer G.W, & Fransen P. (2020). Ex vivo aortic stiffness in mice with different eNOS activity. American journal of physiology. Heart and circulatory physiology, 318(5).
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4

Pharmacological Agents in Research

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Sodium pentobarbital (Nembutal ® ) was obtained from Sanofi (Belgium), indomethacin from Federa (Belgium), L-NAME from Sigma (Belgium), diltiazem hydrochloride, levcromalkalim from TOCRIS (United Kingdom), GSK-7975A was a kind gift of Malcolm Begg (Transfer Material Agreement, April 12, 2013, GlaxoSmithKline Research & Development limited) .
De Moudt S., De Munck D., Coornaert I, & Fransen P. (2021). GSK-7975A, an inhibitor of Ca2+ release-activated calcium channels, depresses isometric contraction of mouse aorta. European journal of pharmacology, 906.
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