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Poloxamer 407

Manufactured by Anatrace

Poloxamer 407 is a non-ionic, triblock copolymer surfactant that is commonly used in various laboratory and pharmaceutical applications. It is composed of hydrophilic polyethylene oxide (PEO) and hydrophobic polypropylene oxide (PPO) blocks arranged in a PEO-PPO-PEO structure. The primary function of Poloxamer 407 is to act as an emulsifier, solubilizer, and wetting agent, facilitating the formulation of stable suspensions, solutions, and dispersions.

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2 protocols using poloxamer 407

1

Solvent-Assisted Diclofenac Drug Formulation

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Poloxamer 407 was purchased from Anatrace (Maumee, OH; sold as Pluronic® F-127). Diclofenac sodium, gentamicin sulfate, HPLC-grade water, and acetonitrile were purchased from Sigma Aldrich (St. Louis, MO). Diclofenac potassium and diclofenac epolamine were purchased from SelleckChem (Houston, TX). Diclofenac diethylamine was purchased from MedChemExpress (Monmouth Junction, NJ). Formic acid was purchased from Avantor (Center Valley, PA). Solid sodium bicarbonate was purchased from Research Products International (Mt. Prospect, IL). HEPES free acid was purchased from GoldBio (St. Louis, MO). Sodium hydroxide solution (1 N) and methanol Optima® were purchased from Fisher Chemical (Fair Lawn, NJ).
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2

Poloxamer 407-based Diclofenac Formulation

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Poloxamer 407 was purchased from Anatrace (Maumee, OH; sold as Pluronic® F-127). Diclofenac sodium salt, gentamicin sulfate, HPLC-grade water, and acetonitrile were purchased from Sigma-Aldrich (St. Louis, MO, USA). Formic acid was purchased from Avantor (Center Valley, PA, USA). HEPES free acid and solid sodium bicarbonate were purchased from Research Products International (Mt. Prospect, IL, USA). Sodium hydroxide solution (1 N) was purchased from Fisher Chemical (Fair Lawn, NJ, USA).
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