Au640 clinical chemistry analyzer

Manufactured by Olympus

Sourced in Germany

The AU640 Clinical Chemistry Analyzer is a fully automated system designed for clinical chemistry analysis. It is capable of performing a wide range of diagnostic tests on various sample types, including serum, plasma, and urine. The analyzer utilizes advanced spectrophotometric technology to provide accurate and reliable results.

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Lab products found in correlation

Dpp4 inhibitor, by Merck Group (1 mentions) Protease inhibitor cocktail, by Merck Group (1 mentions) Ethylene diamine tetraacetic acid (edta), by Terumo (1 mentions) Advia120 hematology analyzer, by Bayer (1 mentions) Hst201, by Sysmex (1 mentions) Ca 7000, by Sysmex (1 mentions) Bn 2, by Siemens (1 mentions) Ra 1000, by Bayer (1 mentions)

Close spelling variants of this product

AU640 analyzer AU640

8 protocols using au640 clinical chemistry analyzer

Metabolic Profile of ASGR-1 Knockout Mice

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Example 2

ASGR-1 KO mice (strain B6.129S4-ASGR-1^tmISau/SaubJxmJ) were obtained from Jackson Labs and maintained on a chow diet. Serum was collected from male and female animals after a 4 hr fast and tested in an Olympus AU640 Clinical Chemistry Analyzer. Compared to wild-type mice, serum ALP is elevated in ASGR-1 knockout mice (*, p<0.05; ****, p<0.0001, one-way ANOVA with Dunnett test). Levels of alanine transaminase (ALT) and aspartate transaminase (AST) were not significantly different between the groups. These data are summarized in FIG. 7 herein. WT=wild-type; HE=heterozygous; HO=homozygous.

US11066472B2. Methods of treating cardiovascular disease with an anti-ASGR antibody or binding fragments thereof (2021-07-20). Amgen Inc. [US]. Inventors: Paul Nioi [US], Peter Coward [US], Christopher Murawsky [CA].

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Characterization of ASGR-1 Knockout Mice

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Example 2

ASGR-1 KO mice (strain B6.129S4-ASGR-1^tm1Sau/SaubJxmJ) were obtained from Jackson Labs and maintained on a chow diet. Serum was collected from male and female animals after a 4 hr fast and tested in an Olympus AU640 Clinical Chemistry Analyzer. Compared to wild-type mice, serum ALP is elevated in ASGR-1 knockout mice (*, p<0.05; ****, p<0.0001, one-way ANOVA with Dunnett test). Levels of alanine transaminase (ALT) and aspartate transaminase (AST) were not significantly different between the groups. These data are summarized in FIG. 7 herein. WT=wild-type; HE=heterozygous; HO=homozygous.

US10358497B2. Methods of treating cardiovascular disease with an ASGR inhibitor (2019-07-23). Amgen Inc [US]. Inventors: Paul Nioi [US], Jun Zhang [US], Yang Li [US].

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Comprehensive Metabolic Profiling of Patients

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Blood samples of the patients were centrifuged at 4°C and the obtained serum samples were stored in aliquots at –80°C. All laboratory parameters, including cardiac troponin, CK, CK-MB, plasma glucose, creatinine, uric acid, homocysteine, trigly-cerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol concentrations were measured in the two hospitals using uniform equipment and reagents (Olympus AU640 Clinical Chemistry Analyzer, Olympus Diagnostica, Hamburg, Germany). Homocysteine was detected using high-performance liquid chromatography with fluorescence detection.

Fan Y., Wang J., Zhang S., Wan Z., Zhou D., Ding Y., He Q, & Xie P. (2017). Homocysteine enhances the predictive value of the GRACE risk score in patients with ST-elevation myocardial infarction. Anatolian Journal of Cardiology, 18(3), 182-193.

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Plasma and Serum Biomarker Analysis

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Plasma and serum were prepared using EDTA and T-MG tubes, respectively [Terumo Medical Corporation, Elkton, MD]. EDTA tubes used to prepare plasma for hormone analysis contained 50 μM DPP IV inhibitor [Millipore, St. Charles, MO] and a protease inhibitor cocktail [Sigma-Aldrich, St. Louis, MO]. Clinical chemistry analysis was performed by standard techniques using an Olympus AU640 Clinical Chemistry analyzer (Olympus America Inc., Melville, NY). Insulin, amylin, leptin, ghrelin, GIP and PYY were analyzed using Milliplex MAP Mouse Gut Hormone Panel and MSD assays were used for measurement of aGLP-1 and tGLP-1 (Meso Scale Discovery, Gaithersburg, MD). Glycated hemoglobin (HbA1c) in blood hemolysates was analyzed with a Primus ultra2 liquid affinity chromatograph (Trinity Biotech, Jamestown, NY).

Rajpal D.K., Klein J.L., Mayhew D., Boucheron J., Spivak A.T., Kumar V., Ingraham K., Paulik M., Chen L., Van Horn S., Thomas E., Sathe G., Livi G.P., Holmes D.J, & Brown J.R. (2015). Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models. PLoS ONE, 10(12), e0145499.

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Hematology and Clinical Chemistry Analyses

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Each group of P₁ males and females was divided into two approximately equally sized subsets for hematology or clinical chemistry. Blood samples for hematology (5–8 animals/sex/group) or clinical chemistry (6–8 animals/sex/group) measurements were collected from the vena cava while each animal was under isoflurane anesthesia.
The following parameters were assessed with a Bayer^® Advia 120 hematology analyzer: red blood cell count (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular (cell) volume (MCV), mean corpuscular (cell) hemoglobin, mean corpuscular (cell) hemoglobin concentration (MCH), red cell distribution width (RDW), absolute reticulocyte count (ARET), platelet count, white blood cell count, and differential white blood cell count. The following parameters were assessed with an Olympus® AU640 clinical chemistry analyzer: aspartate aminotransferase (AST), alanine aminotransferase (ALT), sorbitol dehydrogenase (SDH), alkaline phosphatase (ALKP), total bilirubin (BILI), urea nitrogen (BUN), creatinine (CREA), cholesterol (CHOL), triglycerides, glucose, total protein, albumin, globulin, calcium, inorganic phosphorus, sodium, potassium, chloride, and total bile acids (TBA).

Mukerji P., Rae J.C., Buck R.C, & O’Connor J.C. (2014). Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice. Toxicology Reports, 2, 130-143.

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Fecal Bile Acid Extraction and Quantification

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Fecal extraction was performed using a method described previously [21 (link)]. Fecal total BAs were measured with the Olympus AU640 clinical chemistry analyzer.

Bhutta H.Y., Rajpal N., White W., Freudenberg J.M., Liu Y., Way J., Rajpal D., Cooper D.C., Young A., Tavakkoli A, & Chen L. (2015). Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats. PLoS ONE, 10(3), e0122273.

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Cardiovascular Biomarker Measurement Protocol

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For measurements of hemoglobin (HB), blood cell counts or high-sensitivity C-reactive protein (hs-CRP), blood was collected via the median cubical vein using EDTA-containing tubes at admission and daily afterwards. HB, white blood cell (WBC) and neutrophils were measured with automated cell counters via standard techniques by HST201 (Sysmex, Japan). hs-CRP was measured by high-sensitivity particle-enhanced immunoturbidimetric method using BN II (Siemens, Germany). Blood was also drawn into sodium citrate-containing tubes, at admission and then daily after a 12-h overnight fasting for measurements of fibrinogen, D-dimer and fibrinogen degradation products (FDP), by using the latex agglutination test (Sysmex CA − 7000, Sysmex, Japan). To detect the peak of creatine kinase-MB (CK-MB), blood was collected into tubes containing no anticoagulant at admission and then every 6 h after symptom onset for 24 h, CK-MB were determined by the spectrophotometric method using the Olympus AU640 Clinical Chemistry analyzer (Olympus Diagnostica, Hamburg, Germany).

Lu Q., Liu P., Huo J.H., Wang Y.N., Ma A.Q., Yuan Z.Y., Du X.J, & Bai L. (2020). Cardiac rupture complicating acute myocardial infarction: the clinical features from an observational study and animal experiment. BMC Cardiovascular Disorders, 20, 409.

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Comprehensive Biomarker Profiling for Cardiovascular Risk

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Nonfasting blood samples were drawn into plain and citrate bottles. Blood samples were processed directly at the Department of Clinical Biochemistry, University of Cambridge, or stored at −80°C. Serum levels of total cholesterol, HDL‐C, and triglycerides were measured in fresh samples with RA 1000 (Bayer Diagnostics). Low‐density lipoprotein cholesterol levels were calculated using the Friedewald formula. Because of limited funding, HbA1c levels were measured for participants from 1995 only; this approximates a random subset of the cohort. HbA1c was measured on fresh EDTA blood samples using high‐performance liquid chromatography (Diamat Automated Glycated Hemoglobin Analyzer; Bio‐Rad Laboratories Ltd). When additional funding became available in 2010, serum concentrations of CRP were measured for all participants with available frozen baseline serum samples using a full‐range, high‐sensitivity assay on an Olympus AU640 clinical chemistry analyzer (Olympus UK Ltd).

van Wijk D.F., Boekholdt S.M., Arsenault B.J., Ahmadi‐Abhari S., Wareham N.J., Stroes E.S, & Khaw K. (2016). C‐Reactive Protein Identifies Low‐Risk Metabolically Healthy Obese Persons: The European Prospective Investigation of Cancer–Norfolk Prospective Population Study. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 5(6), e002823.

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