Crgdyk

Manufactured by GL Biochem

Sourced in China, United States

CRGDyK is a chemical compound used in laboratory research. It serves as a cell adhesion peptide, facilitating the attachment of cells to various surfaces. The core function of CRGDyK is to enable cell-substrate interactions, making it a valuable tool for studies involving cell culture, tissue engineering, and related applications.

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Lab products found in correlation

Ir783, by Merck Group (1 mentions) Hoechst 33342, by Beyotime (1 mentions) Wpmy 1, by American Type Culture Collection (1 mentions)

2 protocols using crgdyk

Synthesis of Integrin-Targeted Nanoprobes

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The multi-modal nanoprobes were synthesized as previously reported 14 (link). The cyclic peptide cRGDyK (GL Biochem, China), Gd³⁺-DTPA, IR783 (home-made 16 (link)), and rhodamine (Sigma-Aldrich, USA) were functionalized into the fifth generation (G5) PAMAM dendrimer (Weihai CY Dendrimer Technology, China) to generate the α_νβ₃ integrin-targeted nanoprobe Den-RGD. The control nanoprobe Den-PEG, which has a similar chemical structure to Den-RGD but without the cyclic peptide-targeting domain, was also prepared. The characterization of the nanoprobes is described in the supplementary material.

Bai Y.Y., Gao X., Wang Y.C., Peng X.G., Chang D., Zheng S., Li C, & Ju S. (2014). Image-guided Pro-angiogenic Therapy in Diabetic Stroke Mouse Models Using a Multi-modal Nanoprobe. Theranostics, 4(8), 787-797.

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Synthesis and Evaluation of RE-based Nanomedicine

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RE₂O₃ (RE = Y, Yb, and Er) was purchased from Aladdin Reagent Company. RECl₃ was prepared by dissolving the corresponding RE₂O₃ in hydrochloric acid. Following evaporation, the products were then redissolved in distilled water. Zinc (II) phthalocyanine (ZnPc, 95%, Alfa Aesar), oleic acid (OA, 90%, Aladdin), 1-octadecen (ODE, 90%, Aladdin), Hoechst 33342 (Beyotime), and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT, 98%, Aladdin) were used as received. c(RGDyK) (GL Biochem), Doxil (Fudan-zhangjiang Bio-Pharmaceutical), PC-3 (human prostate carcinoma) and WPMY-1 (human prostatic stromal myofibroblast) cell lines were purchased from American Type Culture Collection (ATCC, USA). WPMY-1 and PC-3 cells were maintained in RPMI 1640 medium supplemented with 10% fetal bovine serum (FBS) and 1% penicillin/streptomycin.

Gao W., Wang Z., Lv L., Yin D., Chen D., Han Z., Ma Y., Zhang M., Yang M, & Gu Y. (2016). Photodynamic Therapy Induced Enhancement of Tumor Vasculature Permeability Using an Upconversion Nanoconstruct for Improved Intratumoral Nanoparticle Delivery in Deep Tissues. Theranostics, 6(8), 1131-1144.

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