Eight-week-old female NOD/SCID mice (Jackson Labs, Bar Harbor, ME) were implanted subcutaneously at the right flank with 5 × 106 H3122 cells. Tumor volumes were determined using a caliper and calculated with the formula: 0.5 × width2 × length. Once the tumor volume reached 100-150 mm3, mice were divided randomly to be treated with ceritinib at 25 mg/kg or vehicle by oral gavage (8 mice/group). Before drug treatment, mice with H3122 xenografts were scanned with the Inveon preclinical small-animal PET/computerized tomography (CT) system (Siemens Healthcare, Malvern, PA) one hour after intravenous injection of 300 μCi of 18F-FDG (IBA Molecular Inc., Sterling, VA). The mice underwent repeat PET/CT imaging after 2.5 and 5 days of daily treatment with ceritinib or vehicle. The 18F-FDG uptake was expressed as the percentage injected dose per gram tissue (%ID/g). All animal experiments were conducted in compliance with the policies and regulations of VCU IACUC.
Inveon preclinical small animal pet computerized tomography system
Manufactured by Siemens
The Siemens Inveon preclinical small-animal PET/computerized tomography (CT) system is a laboratory equipment designed for the acquisition of high-resolution, three-dimensional images of small animals. The system combines positron emission tomography (PET) and computed tomography (CT) technologies to provide comprehensive data on the anatomical and functional characteristics of the subject under investigation.
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2 protocols using inveon preclinical small animal pet computerized tomography system
1
Evaluating Ceritinib Efficacy in H3122 Xenografts
2
Evaluating Ceritinib Efficacy in H3122 Xenografts
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Eight-week-old female NOD/SCID mice (Jackson Labs, Bar Harbor, ME) were implanted subcutaneously at the right flank with 5 × 106 H3122 cells. Tumor volumes were determined using a caliper and calculated with the formula: 0.5 × width2 × length. Once the tumor volume reached 100-150 mm3, mice were divided randomly to be treated with ceritinib at 25 mg/kg or vehicle by oral gavage (8 mice/group). Before drug treatment, mice with H3122 xenografts were scanned with the Inveon preclinical small-animal PET/computerized tomography (CT) system (Siemens Healthcare, Malvern, PA) one hour after intravenous injection of 300 μCi of 18F-FDG (IBA Molecular Inc., Sterling, VA). The mice underwent repeat PET/CT imaging after 2.5 and 5 days of daily treatment with ceritinib or vehicle. The 18F-FDG uptake was expressed as the percentage injected dose per gram tissue (%ID/g). All animal experiments were conducted in compliance with the policies and regulations of VCU IACUC.
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