Biograph t6

Manufactured by Siemens

Sourced in United States

The Siemens Biograph T6 is a positron emission tomography (PET) scanner designed for medical imaging applications. It provides high-resolution imaging capabilities to support clinical diagnosis and research. The core function of the Biograph T6 is to detect and measure the distribution of radioactive tracer molecules within the body, enabling the visualization of physiological processes.

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Lab products found in correlation

Biograph classic, by Siemens (2 mentions)

4 protocols using biograph t6

Standardized FDG PET/CT Imaging Protocols

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FDG PET/CT scans were performed at two institutions: University of Michigan Hospital (UMH) and Veterans Administration Health Center/Veterans Affairs Medical Center, Ann Arbor (VA-AA) between 2003 and 2010. The PET protocols used at both institutions were standardized throughout this time period. Details of the PET/CT scan protocols have been previously described [10 (link)]. At the UMH between 2003 and 2006, the PET/CT imaging was performed on a Siemens Biograph Classic (Siemens Medical Solutions, Hoffman Estates, IL, USA) and between 2006 and 2010 on a Siemens Biograph T6. All PET/CT studies at the VA Ann Arbor Medical Center were performed on a Siemens Biograph T6.

Wang J., Wong K.K., Piert M., Stanton P., Frey K.A, & Kong F.M. (2015). Metabolic response assessment with 18F-FDG PET/CT: inter-method comparison and prognostic significance for patients with non-small cell lung cancer. Journal of Radiation Oncology, 4(3), 249-256.

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Standardized FDG PET/CT Imaging Protocol

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FDG PET/CT scans were performed at two institutions between 2003 and 2013. The ¹⁸F-FDG PET/CT imaging protocols used at both institutions were standardized throughout this time period and the details were published previously [17 (link)]. At one center, PET/CT imaging was performed on a Siemens Biograph Classic (Siemens Medical Solutions, Hoffman Estates, IL, USA) from 2003 to 2006 and on a Siemens Biograph T6 from 2006 to 2013. All PET/CT studies at another medical center were performed on a Siemens Biograph T6. FDG-PET/CT scanning was performed in a standardized fashion on a flat table top, with patients’ arms raised above the head in the treatment position. The CT images (5-mm slices) for the PET/CT study typically were obtained during shallow breathing. Emission PET images were obtained beginning 60 minutes after administration of 8–10 mCi of [¹⁸F]FDG. For the PET scan, the blood glucose level was required to be less than 150 mg/mL.
FDG-PET/CT images from the diagnostic radiology department were transferred to the Functional Image Analysis Tool (FIAT, in house system) and the UM-Plan system (in-house planning systems). Imaging data sets were co-registered according to anatomic match (CT of PET/CT registered to CT simulation based on CT anatomy).

Kong F.M., Li L., Wang W., Campbell J., Waller J.L., Piert M., Gross M., Cheng M., Owen D., Stenmark M., Huang C., Frey K.A., Haken R.K, & Lawrence T.S. (2018). Greater Reduction in Mid-treatment FDG-PET Volume May Be Associated with Worse Survival in Non-Small Cell Lung Cancer. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 132, 241-249.

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FDG-PET/CT Imaging Protocol for Head and Neck Cancer

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Pre-therapy FDG-PET/CT studies were available for 140 (64%) patients. Per institutional protocol, patients fasted for >4–6 hours and had glucose levels <250 mg/dL prior to undergoing PET/CT. Sixty minutes following intravenous administration of 300 MBq (8 mCi) of FDG, sequential PET and CT imaging was performed on an integrated PET/CT scanner (Siemens Biograph T6; Siemens Medical Solutions, Hoffman Estates, IL, USA). Helical CT from skull vertex to mid-thigh was performed with 5 mm collimation, followed immediately by whole body PET at multiple overlapping bed positions and then by dedicated contrast-enhanced head and neck CT. Contrast-enhanced head and neck CT and attenuation-corrected FDG-PET images were co-registered and reviewed on a workstation using software with fusion capability (MedImage; MedView Pty, Canton, MI, USA) by 2 readers (one head and neck radiologist and one nuclear medicine physician) providing a single read per study. A region of interest was defined for each primary tumor and for cervical lymph nodes (LNs) displaying FDG uptake above background using the corresponding CT images for anatomic orientation. The maximum standardized uptake values (SUV_max) for the primary tumor and for the involved LN with the highest SUV_max on PET were retrospectively recorded.

Vainshtein J.M., Spector M.E., McHugh J.B., Wong K.K., Walline H.M., Byrd S.A., Komarck C.M., Ibrahim M., Stenmark M.H., Prince M.E., Bradford C.R., Wolf G.T., McLean S., Worden F.P., Chepeha D.B., Carey T, & Eisbruch A. (2014). Refining Risk Stratification for Locoregional Failure after Chemoradiotherapy in Human Papillomavirus-Associated Oropharyngeal Cancer. Oral oncology, 50(5), 513-519.

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PET/CT Imaging Protocol for Metabolic Quantification

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Sequential PET and CT imaging were performed on an integrated PET/CT scanner (Siemens Biograph T6; Siemens Medical Solutions, Hoffman Estates, IL, USA). Helical CT with 5 mm collimation from skull vertex to mid-thigh followed immediately by whole body PET at multiple overlapping bed positions. FDG-PET/CT images were co-registered and reviewed on workstations using software with fusion capability (MedImage; MedView Pty, Canton, MI, USA). SUV measurements based on body weight (SUV_kg) were calculated from attenuation corrected images with regions of interest (ROI) drawn over the right hepatic lobe (if uninvolved of disease per Wahl et al.), spleen (if uninvolved of disease), mediastinal blood pool in the ascending aorta/aortic arch, bilateral basal ganglia at the level of the internal capsule, and the entire brain at the same slice as that selected for basal ganglia analysis. ROI’s were either circular/ellipsoid to best fit the anatomy with the exception of the liver, which was circular and fixed at 3 cm diameter at the approximate segment VI/VIII level per Wahl and colleagues recommendations for metabolic tumor response criteria. ROI’s in the aorta were sized to maximize measurement volume excluding vessel wall and/or atherosclerotic disease. For each ROI, maximum, mean and minimum SUV_kg measurements were obtained.

Viglianti B.L., Wong K.K., Wimer S.M., Parameswaran A., Nan B., Ky C., Townsend D.M., Rubello D., Frey K.A, & Gross M.D. (2017). Effect of hyperglycemia on brain and liver 18F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 88, 1038-1045.

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