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Acid terminated plga lactide glycolide 50 50

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Acid-terminated PLGA (lactide/glycolide (50:50)) is a copolymer composed of lactic acid and glycolic acid monomers. It has a 50:50 ratio of lactide to glycolide and a carboxylic acid end group. This polymer is commonly used in various biomedical applications.

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Lab products found in correlation

Tboc peg3500 nh2 hcl, by JenKem Technology (2 mentions) Triton x 100, by Merck Group (1 mentions) 1 ethyl 3 3 dimethylaminopropyl carbodiimide edc, by Merck Group (1 mentions) N hydroxysuccinimide nhs, by Merck Group (1 mentions) Cyclohexane, by Merck Group (1 mentions) Cisplatin, by Thermo Fisher Scientific (1 mentions) Hexanol, by Merck Group (1 mentions) N n diisopropylethylamine dipea, by Merck Group (1 mentions) P anisic acid, by Merck Group (1 mentions) Ipi 549, by Chemietek (1 mentions)

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PLGA 50:50 (3 citations)

2 protocols using acid terminated plga lactide glycolide 50 50

1

Synthesis and Characterization of PEGylated PLGA Nanoparticles

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tBOC-PEG3500-NH2·HCl and mPEG3000-NH2·HCl were ordered from JenKem Technology USA, Inc. (Allen, TX). Acid-terminated PLGA (lactide/glycolide (50:50)) was purchased from DURECT Corporation (Pelham, AL). Cisplatin was purchased from Acros Organics (Fair Lawn, NJ). RAPA was purchased from ChemieTek (Indianapolis, IN). Hexanol, Triton X-100, cyclohexane, p-anisic acid, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide (EDC), N-hydroxysuccinimide (NHS), and N,N-diisopropylethylamine (DIPEA) were obtained from Sigma-Aldrich (St. Louis, MO). DOPA was purchased from Avanti Polar Lipids (Alabaster, AL). 3H-Labeled paclitaxel[o-benzamido-3H(N)] and 14C-labeled stearic acid were purchased from Moravek Biochemicals and Radiochemicals (Brea, CA).
Guo S., Lin C.M., Xu Z., Miao L., Wang Y, & Huang L. (2014). Co-delivery of Cisplatin and Rapamycin for Enhanced Anticancer Therapy through Synergistic Effects and Microenvironment Modulation. ACS Nano, 8(5), 4996-5009.
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2

Synthesis of PLGA-based Nanoparticles

Cited 1 time
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IPI-549 was purchased from Chemietek (Indianapolis, IN, USA). Acid-terminated PLGA (lactide/glycolide (50:50)) was purchased from DURECT (Pelham, AL, USA). mPEG3500-NH2⋅HCl and tBOC-PEG3500-NH2⋅HCl were purchased from JenKem Technology USA, Inc. (Allen, TX). PLGA-PEG and PLGA-PEG-AEAA were synthesized according to our previous work, and the structures were confirmed by 1H-NMR (Guo et al., 2014 (link)). If not specifically mentioned, all other chemicals were purchased from Sigma-Aldrich (St. Louis, MO, USA).
Zhang X., Shen L., Liu Q., Hou L, & Huang L. (2019). Inhibiting PI3 Kinase-γ in Both Myeloid and Plasma Cells Remodels the Suppressive Tumor Microenvironment in Desmoplastic Tumors. Journal of controlled release : official journal of the Controlled Release Society, 309, 173-180.
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