Lgx818

Manufactured by MedChemExpress

LGX818 is a laboratory equipment product manufactured by MedChemExpress. It is designed to perform specific tasks in a research or laboratory setting. The core function of LGX818 is to facilitate the execution of various experimental procedures, but a detailed description of its intended use cannot be provided while maintaining an unbiased and factual approach.

Automatically generated - may contain errors

Lab products found in correlation

Gsk2118436a, by Selleck Chemicals (2 mentions) Plx4032, by MedChemExpress (2 mentions) Plx8394, by MedChemExpress (2 mentions) Az628, by Selleck Chemicals (1 mentions) Ly3009120, by Selleck Chemicals (1 mentions) Tak 632, by Selleck Chemicals (1 mentions) Gdc 0879, by Selleck Chemicals (1 mentions) Azd6244, by Selleck Chemicals (1 mentions) E 100, by Alomone (1 mentions)

2 protocols using lgx818

Comparative Analysis of BRAF and MEK Inhibitors

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BRAFi used are as follows: PLX4032 (vemurafenib; MedChemExpress, #HY-12057), LGX818 (encorafenib; MedChemExpress, #HY-15605), GSK2118436A (dabrafenib; Selleckchem, #S2807), PLX8394 (MedChemExpress, #HY-18972), AZ628 (Selleckchem, #S2746), GDC0879 (Selleckchem, #S1104), LY3009120 (Selleckchem, #S7842), and TAK632 (Selleckchem, #S7291). MEKi used are as follows: AZD6244 (selumetinib; Selleckchem, #S1008), BAY86-9766 (refametinib; MedChemExpress, #HY-102156), and benzyl-coelenterazine (NanoLight, #301).

Röck R., Mayrhofer J.E., Torres-Quesada O., Enzler F., Raffeiner A., Raffeiner P., Feichtner A., Huber R.G., Koide S., Taylor S.S., Troppmair J, & Stefan E. (2019). BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS. Science Advances, 5(8), eaav8463.

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Evaluating BRAF inhibitor combinations

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The reagents used included PLX4032 (vemurafenib; MedChemExpress, HY-12057), LGX818 (encorafenib; MedChemExpress, HY-15605), GSK2118436A (dabrafenib; Selleckchem, S2807), PLX8394 (MedChemExpress, HY-18972), Benzyl-coelenterazine (Nanolight, 301), and human EGF (Alomone Labs, E-100).

Mayrhofer J.E., Enzler F., Feichtner A., Röck R., Fleischmann J., Raffeiner A., Tschaikner P., Ogris E., Huber R.G., Hartl M., Schneider R., Troppmair J., Torres-Quesada O, & Stefan E. (2020). Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies. Proceedings of the National Academy of Sciences of the United States of America, 117(49), 31105-31113.

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