Spss statistical program version 23

Nonparametric tests were used because of small sample sizes and non-normal distribution of data. Fisher´s exact test was used when comparing extent of tumour removal (GTR vs. subtotal resection (STR)) with postoperative seizure outcome. In-between group comparisons of immunohistochemical findings with dichotomized IRS (absent/low vs. intermediate/high) and BRAFV600E expression and categorical clinical variables, i.e. tumour location (temporal vs. extratemporal) and seizure frequency (medically controlled vs. refractory) were also analysed with Fisher´s exact test. All statistical tests were 2-tailed, and the level of significance was set at p < 0.05. The statistical analysis was performed with the SPSS statistical program, version 23.

Statistical analyses were conducted with the SPSS statistical program, version 23. For each parameter, mean and standard deviation (SD) were computed. A general linear model was used to compare scores of the AMED and AO condition for the KSS and subjective intoxication on each BAC level. As it is essential to have similar BACs to allow a meaningful comparison between the two treatment conditions, the BAC difference between the two conditions was used as covariate in the analyses. Differences were regarded statistically significant if p < 0.05.