Fmoc tyr tbu oh

Manufactured by GL Biochem

Sourced in China

Fmoc-Tyr(tBu)-OH is a chemical compound used in organic synthesis, specifically in the field of peptide synthesis. It is a protected amino acid derivative with a fluorenylmethyloxycarbonyl (Fmoc) protecting group on the amino terminus and a tert-butyl (tBu) protecting group on the hydroxyl group of the tyrosine side chain. This compound is commonly used as a building block in the solid-phase peptide synthesis (SPPS) process.

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Lab products found in correlation

Fmoc lys boc oh, by GL Biochem (2 mentions) Fmoc arg pbf oh, by GL Biochem (2 mentions) Fmoc ser tbu oh, by GL Biochem (2 mentions) Fmoc asn trt oh, by GL Biochem (2 mentions) Fmoc ile oh, by GL Biochem (2 mentions) Fmoc phe oh, by GL Biochem (2 mentions) Fmoc cys trt oh, by GL Biochem (2 mentions) Nonadecanoic acid, by Merck Group (1 mentions) Fmoc trp boc oh, by GL Biochem (1 mentions) N n diisopropylcarbodiimide, by Merck Group (1 mentions) N n diisopropylethylamine, by Merck Group (1 mentions) Fmoc leu, by GL Biochem (1 mentions) Fmoc gly, by GL Biochem (1 mentions) Fmoc his trt oh, by GL Biochem (1 mentions) Fmoc pro oh, by GL Biochem (1 mentions) Matrix metalloproteinase 9 mmp 9, by Merck Group (1 mentions) Thioflavin t, by Merck Group (1 mentions) Trisodium citrate, by Merck Group (1 mentions) Silver nitrate agno3, by Merck Group (1 mentions) Piperidine, by Iris Biotech (1 mentions)

3 protocols using fmoc tyr tbu oh

Peptide Synthesis and Characterization

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The conventional amino acids, Fmoc-Ala, Fmoc-Lys(Boc)-OH, Fmoc-Arg(Pbf)-OH, Fmoc-Gly, Fmoc-His(Trt)-OH, Fmoc-Leu, Fmoc-Ser(tBu)-OH, Fmoc-Thr(OtBu)-OH, Fmoc-Trp(Boc)-OH, Fmoc-Tyr(tBu)-OH, Fmoc-Asn(Trt)-OH, Fmoc-Ile-OH, Fmoc-Phe-OH, Fmoc-Cys(Trt)-OH, Fmoc-Pro-OH, were acquired from GL Biochem Ltd. (Shanghai, China). N,N′-diisopropylcarbodiimide (DIC), Oxyma pure, 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU), N,N-Diisopropylethylamine, triisopropylsilane (TIS), 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP), nonadecanoic acid (C19) were purchased from Sigma-Aldrich (Italy). Rink amide p-methylbenzhydrylamine (MBHA) resin, Fmoc-L-Lys(Mtt)-OH, piperidine, and trifluoroacetic acid (TFA) were purchased from Iris Biotech GmbH (Marktredwitz, Germany). Anhydrous solvents [N,N-dimethylformamide (DMF) and dichloromethane (DCM)], Doxo-EMCH, matrix metalloproteinase-9 (MMP-9) and dialysis tubing benzoylated, Nile Red, and Thioflavin T were purchased from Sigma-Aldrich (Milan, Italy). Silver nitrate (AgNO₃), and trisodium citrate were obtained from Sigma-Aldrich (Luzais, Saint-Quentin-Fallavier, France). Ultrapure water was produced using a Barnstead EASYpure RoDi system (Thermo Fisher Scientific, Villebon sur Yvette, France). All chemicals and reagents were of analytical grade and used as received.

Del Genio V., Falanga A., Allard-Vannier E., Hervé-Aubert K., Leone M., Bellavita R., Uzbekov R., Chourpa I, & Galdiero S. (2022). Design and Validation of Nanofibers Made of Self-Assembled Peptides to Become Multifunctional Stimuli-Sensitive Nanovectors of Anticancer Drug Doxorubicin. Pharmaceutics, 14(8), 1544.

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Peptide Synthesis and Functionalization

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APTES,
dibenzocyclooctyl-N-hydroxy succinimide (DBCO-NHS), N-(dimethylaminopropyl)-N′-carbodiimide
hydrochloride (EDC), triisopropylsilyl
chloride, and 2-azidoacetic acid were procured from Sigma-Aldrich.
Ethanol (ACS grade), potassium hexacyanoferrate(III), potassium hexacyanoferrate(II),
sodium phosphate dibasic, and sodium phosphate monobasic were purchased
from Merck Chemicals. All chemicals were of analytical reagent (AR)
grade and used without further purification. Aqueous solutions were
prepared using Millipore water received from Milli-Q system (Millipore
Inc.). 9-Fluorenylmethyloxycarbonyl (Fmoc)-protected amino acids (Fmoc-Gln(Trt)-OH,
Fmoc-Asn(Trt)-OH, Fmoc-Gly-OH, Fmoc-Pro-OH, Fmoc-Leu-OH, and Fmoc-Ile-OH)
and Fmoc-Rink-Amide-MBHA resin were procured from Iris Biotech GMPH.
Fmoc-Cys(Trt)-OH and Fmoc-Tyr(tBu)-OH were purchased
from GL Biochem Ltd.

Tadi K.K., Alshanski I., Mervinetsky E., Marx G., Petrou P., Dimitrios K.M., Gilon C., Hurevich M, & Yitzchaik S. (2017). Oxytocin-Monolayer-Based Impedimetric Biosensor for Zinc and Copper Ions. ACS Omega, 2(12), 8770-8778.

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Solid-Phase Peptide Synthesis Protocol

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PL-Wang resin (0.4 mmole/g) was obtained from Varian, Inc. (Shropshire, UK). Fmoc-Ser(tBu)-OH, Fmoc-Met-OH, Fmoc-Leu-OH, Fmoc-Ile-OH, Fmoc-Ala-OH, Fmoc-Lys(Boc)-OH, Fmoc-Asp(OtBu)-OH, Fmoc-Asn(trt)-OH, Fmoc-Glu(OtBu)-OH, Fmoc-Phe-OH, Fmoc-Gln(trt)-OH, Fmoc-Tyr(tBu)-OH, Fmoc-Arg(pbf)-OH, N,N′-diisopropylcarbodiimide (DIC), 4-dimethylaminopyridine (DMAP) and triisopropylsilane (TIS) were obtained from GL Biochem Ltd. (Shanghai, China). Fmoc-Val-OH, Fmoc-Gly-OH, Fmoc-His(trt)-OH and N,N,N′,N′-tetramethyl-uronium-hexafluoro-phosphate (HBTU) were obtained from CS Bio Co. (Menlo Park, USA). Dimethylformamide (DMF), dichloromethane (DCM) and dimethyl sulfoxide (DMSO) were obtained from Daejung Chemicals & Metals Co., Ltd. (Siheung, Korea). Anisole, piperidine and N,N-diisopropylethylamine (DIEA) were obtained from Sigma-Aldrich (St. Louis, USA). Trifluoroacetic acid (TFA) was obtained from Yakuri Pure Chemicals Co., Ltd. (Kyoto, Japan). Ether, Anhydrous was obtained from J.T. Baker (Center Valley, USA). Zoletil® (Virbac) and Rompun® (Bayer Parma) were obtained from SMP animal medicine (Suwon, Korea). Protease inhibitor cocktail was obtained from Roche Diagnostics (IN, USA). EDTA treated BD vacutainer® was obtained from Becton, Dickinson and Company (NJ, USA). Human Aβ42 Ultrasensitive ELISA kit was obtained from Invitrogen (CA, USA).

Cho S.M., Kim H.V., Lee S., Kim H.Y., Kim W., Kim T.S., Kim D.J, & Kim Y. (2014). Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model. Scientific Reports, 4, 6777.

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