Optima 450w

Manufactured by GE Healthcare

Sourced in United States

The Optima 450W is a compact and versatile lab centrifuge from GE Healthcare. It is designed for general-purpose laboratory applications, providing reliable and consistent performance. The Optima 450W can accommodate a range of sample volumes and rotor configurations to meet the needs of various laboratory workflows.

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Optima 450w scanner (4 citations) Optima 450w GEM (2 citations)

12 protocols using optima 450w

Multiparametric MRI Imaging Protocol

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All examinations were performed using a 1.5 Tesla (Optima 450W, General Electrics, Milwaukee, Wisconsin, USA) system with 12-channel body-array torso coils. Both axial and sagittal fast spin-echo T2-weighted images (TR, 4500 ms; TE, 102 ms; matrix size, 384 × 256; FOV, 30 cm; slice thickness, 5.5 mm; gap, 1 mm; number of excitations, 4), both axial and sagittal spin-echo T1-weighted images and gadolinium-enhanced fat-saturated spin-echo T1-weighted images (TR, 550 ms; TE, 6.7 ms; matrix size, 384 × 256; FOV, 32 cm; slice thickness, 5 mm; gap, 1 mm; number of excitations, 2) after the administration of gadolinium dimeglumine (0.1 mmol/l per kg bodyweight) were obtained in all patients. The parameters of both axial and sagittal DWI were as follows: TR, 5500–6000 ms; TE, 76–80 ms; b factors 0 and 1000 s/mm²; matrix size, 160 × 192; FOV, 30 cm; slice thickness, 5 mm; number of excitations, 8. ADC maps were automatically generated with the manufacturer’s software.

Çavuşoğlu M., Sözmen Ciliz D., Ozsoy A., Duran S., Elverici E., Atalay C.R., Ozdemir O, & Sakman B. (2016). Diffusion-Weighted Mri of Postmenopausal Women with Vaginal Bleeding and Endometrial Thickening: Differentiation of Benign and Malignant Lesions. Journal of the Belgian Society of Radiology, 100(1), 70.

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Magnetic Resonance Imaging Evaluation of Bone Marrow Lesions

Cited 1 time

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MRI scans were performed at the Royal Hobart Hospital at screening and
6 months with a 1.5T noncontrast scan (GE Optima 450W, Milwaukee, USA) using
a dedicated 8-channel knee coil. The study knee was scanned in the sagittal
plane using a proton density-weighted, fat saturation, 2-dimension fast spin
echo MRI sequence (repetition time 3800 ms, echo time 39 ms), with a slice
thickness of 3 mm and spacing 1.5 mm, flip angle 150°, 512 × 512-pixel
matrices, and a field of view 16 cm.^{28 (link)}A BML was defined as an area of increased signal intensity adjacent to the
subchondral bone. The presence of BMLs at the screening was assessed by an
experienced MRI reader (DA) for the purposes of patient enrolment. BMLs were
scored blinded to treatment allocation by a trained observer (GC) using
OsiriX software (University of Geneva, Geneva, Switzerland). Screening and
6 months scans were read in pairs with the chronological order known to the
observer. For each of the medial femoral, lateral femoral, medial tibial,
lateral tibial, and patellar sites, the maximum area (mm²) on MRI
slices was measured independently and then summed to create a total BML
area. Intraclass correlation coefficients (two-way mixed effects model^{33 (link)}) of the total BML area ranged from 0.86 to 0.94.

Cai G., Laslett L.L., Aitken D., Cicuttini F., March L., Hill C., Winzenberg T, & Jones G. (2019). Zoledronic acid plus methylprednisolone versus zoledronic acid or placebo in symptomatic knee osteoarthritis: a randomized controlled trial. Therapeutic Advances in Musculoskeletal Disease, 11, 1759720X19880054.

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Multimodal Imaging of Liver Steatosis

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Non-contrast chest CTs were obtained in the supine position in a single breath-hold on several CT platforms (Lightspeed Ultra, Lightspeed VCT, Discovery CT750HD, and Revolution, GE Healthcare; Somatom Definition Flash, Somatom Definition AS, Sensation Cardiac 64, and Force, Siemens Healthineers) using clinical acquisition protocols: 100 or 120 kVp, 106–663 mA, 0.600 mm (Siemens), 0.625 or 1.25 mm (GE) collimation, slice thickness 1.00–3.00 mm, and reconstruction kernels of B40f for Somatom Definition AS and Sensation Cardiac 64, I31f for Somatom Definition Flash, and standard for all GE scanners. Liver attenuation on CT was measured in HU on mediastinal window settings (width 350 HU; level 25 HU).
Multichannel MRI systems were used for all patients (1.5T: Avanto, Aera, and Sonata, Siemens Healthineers; and Signa HD and Optima 450w, GE Medical Systems or 3T: Skyra and Biograph mMR, Siemens Healthineers; and Discovery 750, GE Medical Systems) [27 ]. The liver MRI sequences and acquisition parameters followed clinical protocols. T1WI in- and out-of-phase imaging was performed in all cases and used to calculate the fat fraction percentage (FF).

Jirapatnakul A., Reeves A.P., Lewis S., Chen X., Ma T., Yip R., Chin X., Liu S., Perumalswami P.V., Yankelevitz D.F., Crane M., Branch A.D, & Henschke C.I. (2019). Automated measurement of liver attenuation to identify moderate-to-severe hepatic steatosis from chest CT scans. European journal of radiology, 122, 108723.

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Multimodal Neuroimaging for Preoperative Planning

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Prior to the procedure, MRI was obtained with a 3-T scanner (19-channel; Discovery MR750w [GE Healthcare, Waukesha Wisconsin, USA]). Sequences obtained for preoperative planning included the following: axial 3-dimensional T1 spoiled gradient recalled acquisition, axial 2-dimensional T2 (2-mm slice thickness), sagittal/coronal 3-dimensional T2 fast spin echo, axial susceptibility-weighted angiography, and diffusion tensor imaging (33 gradient directions, one B0 scan, field of view 26 cm, 128 × 128 acquisition matrix, slice thickness 3 mm, b value = 1000–2000s/mm²).
On the day of surgery, MRI was obtained at 1.5 T (12-channel; Optima 450w [GE Healthcare]) after placement of the Leksell frame. T1 images were obtained in axial/sagittal planes after administration of contrast. Immediate postoperative imaging during the same admission consisted of axial/sagittal T1, axial (3-mm slice thickness) and coronal T2, and axial diffusion-weighted imaging, also at 1.5 T, in addition to a computed tomography (CT) scan (1-mm thickness).

Yang A.I., Buch V.P., Heman-Ackah S.M., Ramayya A.G., Hitti F.L., Beatson N., Chaibainou H., Yates M., Wang S., Verma R., Wolf R.L, & Baltuch G.H. (2020). Thalamic Deep Brain Stimulation for Essential Tremor: Relation of the Dentatorubrothalamic Tract with Stimulation Parameters. World neurosurgery, 137, e89-e97.

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MRI Protocols across Vendor Platforms

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The MRI examinations were performed in a variety of 1.5 T scanners-Aera (Siemens Medical Solutions); Espree (Siemens Medical Solutions); Avanto (Siemens Medical Solutions); and Optima 450W (GE Healthcare, Milwaukee, WI, USA)-and 3.0 T scanners-Achieva (Philips Medical Systems, Best, the Netherlands); Skyra (Siemens Medical Solutions); and HDX (GE Healthcare). All protocols were implemented as described in Table 1.

Helito P.V., Rocha S.R., Ortiz R.T., Cerri G.G., Leite C.D, & Rodrigues M.B. (2020). Accuracy of magnetic resonance imaging for diagnosing hallux valgus. Radiologia Brasileira, 53(2), 81-85.

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Diffusion-Weighted Imaging in Patients with Metal Implants

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The twice-refocused non-linear phase CPMG diffusion preparation with identical phase excitation and tipup was used for all in vivo DW-MSI acquisitions.
A 46-year-old female volunteer with two titanium screws from anterior cruciate ligament (ACL) reconstruction surgery was scanned with approval of the local Institutional Review Board and informed consent at 3T (GE Signa Premier). DW-MSI (b = 400 s/mm²) was compared to self-navigated 4-shot DW-EPI with spectral-spatial fat suppression and reconstructed with MUSE [38 (link)]. DW-MSI scan parameters are shown in Table 1. DW-EPI scan parameters were: matrix 192 × 192, voxel size 0.8 × 0.8 × 4 mm, TR = 2500 ms, TE = 62 ms, 2 NEX b=0 s/mm², 6 NEX b=400 s/mm². Vendor PD and Short-T1 Inversion Recovery (STIR) MAVRIC-SL were acquired for comparison.
The DW-MSI sequence was appended to clinical exams of three patients (two with unilateral hip replacements, one with bilateral intramedullary rods) following informed consent and IRB approval. These acquisitions were performed at 1.5T (GE Healthcare Optima 450W) with 30 mT/m per axis diffusion gradient amplitude and 20 T/m/s slew rate. The exam included T1-weighted and STIR MAVRIC-SL.

Lee P.K., Yoon D., Sandberg J.K., Vasanawala S.S, & Hargreaves B.A. (2022). Volumetric and Multispectral Diffusion Weighted Imaging Near Metallic Implants using a Non-Linear Phase CPMG Diffusion Preparation. Magnetic resonance in medicine, 87(6), 2650-2666.

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MRI Imaging of Shoulder Anatomy

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MR images were obtained using a GE Medical Systems 1.5 Tesla magnet (Optima 450w) and a receiving phased array shoulder coil. Multiplanar pulse sequences included high-resolution proton density and fat-suppressed T2-weighed fast spin echo images as well as short TI inversion recovery images to suppress any susceptibility artifact produced by the anchors. Proton density images offered the best spatial resolution with a frequency/phase acquisition matrix of 416/256. T2-weighted fast spin echo and short TI inversion recovery sequences allowed for fluid-tissue contrast to evaluate for cyst formation and had matrices of 320/256 and 288/224, respectively. All images had a slice thickness of 3 mm with a 1-mm gap.

Matijakovich D., Solomon D., Benitez C.L., Huang H.H., Poeran J., Berger N., Lebaschi A, & Seneviratne A. (2021). Long-term follow-up of perianchor cyst formation after rotator cuff repair. JSES International, 5(5), 863-868.

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Cardiac Amyloidosis Detection via MRE

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We identified endomyocardial-biopsy proven cardiac amyloidosis patients from the amyloid clinic at the Mayo Clinic. Age-and gender-matched controls were recruited from campus postings. Baseline clinical information was acquired from chart review. Subjects underwent a one-time MRE using a vibrating driver on the chest. Images were acquired with a 1.5T MRI scanner (Optima 450W, GE Medical Systems, Milwaukee, WI) at the minimum allowed delay after the R wave using a cardiac-gated MRE spin echo echo planar imaging pulse sequence, at a vibration frequency of 140 Hz. Stiffness maps were generated using local frequency estimation inversion algorithm.

Chang I.C., Arani A., Arunachalam S.P., Grogan M., Dispenzieri A, & Araoz P.A. (2017). Feasibility study of cardiac magnetic resonance elastography in cardiac amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 24(SUP1), 161.

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MRI-Based Diffusion Imaging Protocol

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The study was performed with 1.5-T MRI (Optima 450W, General Electric Medical Systems, Milwaukee, WI). Head coil and immobilization devices were used. The b value was 1000 s/mm² on diffusion-weighted imaging. Image analysis was performed on a workstation (GE Advantage Workstation AW4.2_08) using functool 2 image analysis software (GE Medical Systems).

, & Paşaoğlu L. (2017). Vertebrobasilar system computed tomographic angiography in central vertigo. Medicine, 96(12), e6297.

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Spinal MRI Imaging Protocol

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MRI sequences were acquired using a 1.5-T GE scanner (Optima 450W, Milwaukee, WI), equipped with an 8-channel cervical-thoracic-lumbar surface coil. All patients underwent routine MRI, including sagittal T1 (field of view [FOV], 32–36 cm; slice thickness, 3 mm; repetition time [TR], 400–650 ms; flip angle [FA], 90°, Matrix 256×192), sagittal T2 (FOV, 32–36 cm; slice thickness, 3 mm; TR, 3500–4000 ms; FA, 90°; Matrix 256×192), axial T1 (field of view [FOV], 32–36 cm; slice thickness, 3 mm; repetition time [TR], 400–650 ms; flip angle [FA], 90°, Matrix 256×192), axial T2 (FOV, 32–36 cm; slice thickness, 3 mm; TR, 3500–4000 ms; FA, 90°; Matrix 256×192).

Chen L., Peck K.K., Lis E., Tisnado J., Arevalo-Perez J., Haque S., Karimi S., Yamada Y., Holodny A.I, & Lyo J. (2020). Reliability of CT Myelography versus MRI in the Assessment of Spinal Epidural Disease. Clinical imaging, 62, 37-40.

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