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K41498

Manufactured by Bio-Techne
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Sourced in United States

K41498 is a laboratory equipment product from Bio-Techne. It is a centrifuge that can be used to separate components of a liquid mixture based on their density.

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Lab products found in correlation

Rat human crf, by Merck Group (3 mentions) Sulpiride, by Bio-Techne (2 mentions) Mifepristone, by Bio-Techne (2 mentions) Picrotoxin, by Bio-Techne (2 mentions) Cgp55845, by Bio-Techne (2 mentions) Nbi35965, by Bio-Techne (2 mentions) Forskolin, by Bio-Techne (1 mentions) Sq22536, by Bio-Techne (1 mentions) Kt5720, by Bio-Techne (1 mentions) Astressin 2b, by Bio-Techne (1 mentions) Nbi27914, by Bio-Techne (1 mentions) Cp 154526, by Bio-Techne (1 mentions) Mdl 12330a, by Bio-Techne (1 mentions) Rp camps, by Bio-Techne (1 mentions) Orexin a, by Bio-Techne (1 mentions) Sb 334867, by Bio-Techne (1 mentions) Naloxone hydrochloride, by Merck Group (1 mentions)

7 protocols using k41498

1

Pharmacological Manipulation of CRF2 Signaling

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Sprague-Dawley rats were purchased from Harlan Laboratories. CRF2 homozygous KO mice (Stock number: 010842; Strain name: B6; 129-crhr2tm1jsp/J) and WT mice (from the same colony) were bought from Jackson Laboratories. This study was carried out in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocol was approved by the Committee on the Ethics of Animal Experiments of the University of North Dakota (0702-2). All efforts were made to minimize suffering. CRF was purchased from American Peptide Company (Sunnyvale, CA). The following reagents were products of TOCRIS (Ellisville, MO): K41498, astressin 2B, NBI 27914, CP 154526, MDL 12330A, SQ 22536, forskolin, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione (IBMX), KT 5720, Rp-cAMPS. The other chemicals were purchased from Sigma-Aldrich (St. Louis, MO).
Kurada L., Yang C, & Lei S. (2014). Corticotropin-Releasing Factor Facilitates Epileptiform Activity in the Entorhinal Cortex: Roles of CRF2 Receptors and PKA Pathway. PLoS ONE, 9(2), e88109.
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2

Neurochemical Modulation of Signaling

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DNQX, picrotoxin, CGP55845, sulpiride, CRF, K41498, and mifepristone were obtained from Tocris Biosciences. Caged IP3 was a generous gift from Dr. Kamran Khodakhah (Albert Einstein College of Medicine). All other chemicals were from Sigma-RBI.
Tovar-Díaz J., Pomrenze M.B., Kan R., Pahlavan B, & Morikawa H. (2018). Cooperative CRF and α1 Adrenergic Signaling in the VTA Promotes NMDA Plasticity and Drives Social Stress Enhancement of Cocaine Conditioning. Cell reports, 22(10), 2756-2766.
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3

Neurochemical Modulation of Signaling

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DNQX, picrotoxin, CGP55845, sulpiride, CRF, K41498, and mifepristone were obtained from Tocris Biosciences. Caged IP3 was a generous gift from Dr. Kamran Khodakhah (Albert Einstein College of Medicine). All other chemicals were from Sigma-RBI.
Tovar-Díaz J., Pomrenze M.B., Kan R., Pahlavan B, & Morikawa H. (2018). Cooperative CRF and α1 Adrenergic Signaling in the VTA Promotes NMDA Plasticity and Drives Social Stress Enhancement of Cocaine Conditioning. Cell reports, 22(10), 2756-2766.
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4

Behavioral Pharmacology of Orexin and CRF

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Orexin A, CRF, SB334867 and K41498 were purchased from Tocris Bioscience (Bristol, UK). DL-Amphetamine hydrochloride was purchased from Sigma-Aldrich (St. Louis, MO). For the microdialysis experiments, amphetamine sulfate was donated by Laboratorio Chile S.A (Nuñoa, Santiago, Chile).
Navarro G., Medrano M., Aguinaga D., Vega-Quiroga I., Lillo A., Jiménez J., Casanovas M., Canela E.I., Mallol J., Gysling K, & Franco R. (2019). Differential effect of amphetamine over the corticotropin-releasing factor CRF2 receptor, the orexin OX1 receptor and the CRF2-OX1 heteroreceptor complex. Neuropharmacology, 152.
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5

Pharmacological Modulation of CRF Receptors

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The following drugs were used: rat/human CRF (Sigma-Aldrich, St. Louis, MO, USA); CRF-R2 agonist urocortin-2 (Ucn-2), CRF-R2 antagonist K41498; CRF-R1 antagonist NBI35965 (Bio-Techne GmbH, Wiesbaden-Nordenstadt, Germany). Doses were calculated as the free base and drugs were dissolved in isotonic saline as vehicle. For each dose a separate group of animals (n = 6) was used. Drugs were administered during brief isoflurane anesthesia.
Mousa S.A., Shaqura M., Khalefa B.I., Li L., Al-Madol M.A., Treskatsch S., & Schäfer M. (2021). Functional and anatomical characterization of corticotropin-releasing factor receptor subtypes of the rat spinal cord involved in somatic pain relief.
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6

Pharmacological Modulation of CRF Receptors

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The following drugs were used: rat/human CRF (Sigma-Aldrich, St. Louis, MO); CRF-R1 agonist stressin I and CRF-R1 antagonist NBI 27914 (Bio-Techne GmbH, Wiesbaden-Nordenstadt, Germany); CRF-R2 agonist urocortin-2 (Ucn-2), CRF-R2 antagonist K41498 (Bio-Techne GmbH, Wiesbaden-Nordenstadt, Germany); naloxone hydrochloride (Sigma-Aldrich, St. Louis, MO). Doses were calculated as the free base and drugs were dissolved in isotonic saline as vehicle. The volume of i.c.v. drug administration was 10 µl. For each dose a separate group of animals (n = 6) was used. Drugs were administered under brief isoflurane anesthesia.
Mousa S.A., Khalefa B.I., Shaqura M., Al-Madol M., Treskatsch S, & Schäfer M. (2022). Superior control of inflammatory pain by corticotropin-releasing factor receptor 1 via opioid peptides in distinct pain-relevant brain areas. Journal of Neuroinflammation, 19, 148.
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7

Pharmacological Modulation of CRF Receptors

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The following drugs were used: rat/human CRF (Sigma-Aldrich, St. Louis, MO, USA); CRF-R2 agonist urocortin-2 (Ucn-2), CRF-R2 antagonist K41498; CRF-R1 antagonist NBI35965 (Bio-Techne GmbH, Wiesbaden-Nordenstadt, Germany). Doses were calculated as the free base and drugs were dissolved in isotonic saline as vehicle. For each dose a separate group of animals (n = 6) was used. Drugs were administered during brief isoflurane anesthesia.
Mousa S.A., Shaqura M., Khalefa B.I., Li L., Al-Madol M., Treskatsch S, & Schäfer M. (2021). Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief. Molecular Neurobiology, 58(11), 5459-5472.
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