3T scanner (Skyra; Siemens, Erlangen, Germany). MRI of the brain consisted of an
axial T1-weighted sequence, repetition time (TR) 550 ms, echo time (TE) 8.9 ms,
slice thickness 5 mm; in-plane resolution 0.8984 mm × 0.8984 mm, acquisition
matrix 256 × 216), T2 fat saturation (T2-fs) axial (TR 4000 ms, TE 92 ms, slice
thickness 3 mm, field of view (FOV) 186 × 230 rows, in-plane resolution
0.4492 mm × 0.4492 mm), axial FLAIR sequence (TR 8000 ms, TE 84 ms, slice
thickness 4 mm, acquisition matrix 320 × 210; in-plane resolution 0.7188 mm ×
0.7188 mm), T2 mapping (TR 3100 ms, TE 13.8–165.6 ms with 12 TEs: 13.8 ms,
27.6 ms, 41.4 ms, 55.2 ms, 69 ms, 82.2 ms, 96.6 ms, 110.4 ms, 124.2 ms, 138 ms,
151.8 ms, 165.6 ms) and magnetisation-prepared rapid gradient echo (MPRAGE)
sequence post contrast (TR 2200 ms, TE 2.67 ms, slice thickness 1 mm, inversion
time 900 ms, in-plane resolution 0.9766 × 0.9766 mm, acquisition matrix
256 × 246). T2 maps were reconstructed by using a voxelwise, monoexponential
non-negative least-squares fit analysis (MapIt; Siemens, Erlangen, Germany) with
a voxel size of 1.9 × 1.0 × 3 mm³.