Macrogol 15 hydroxystearate solutol hs15

The reference standards of tanshinone IIA, salvianolic acid B, tanshinone I and cryptotanshinone and internal standard (I.S.) of osthole and ferulic acid were obtained from the National Institutes for Food and Drug Control (Beijing, China). Sodium danshensu and dihydrotanshinone I were sourced from Zelang Medical Technology Co. Ltd. (Nanjing, China). Isopropyl myristate (IPM), Tween-80, PEG400, mannitol, lactose, dextran-40 and glucose were purchased from Sinopharm Chemical Reagent Co. Ltd. (Shanghai, China). Caprylic/capric triglyceride (Labrafac), glyceryl monolinoleate (Maisine 35-1), glyceryl monooleate (Peceol), lauroyl macorgolglycerides (Gelucire44/14), capryloc aproyl macrogol-8 glycerides (Labrasol), oleoyl macrogolglycerides(Labrafil M 1944) and diethylene glycol monoethyl ether (Transcutol P) were obtained from Gattefossé Co. (Lyon, France). Polyoxyl 40 hydrogenated castor oil (Cremophor RH40) and macrogol-15-hydroxystearate (Solutol HS15) were purchased from BASF Co. (Ludwigshafen, Germany). Salvia was purchased from the Jiangsu Province Hospital of TCM and authenticated by Professor Wu (Nanjing University of Chinese Medicine, Nanjing, China). All other chemicals were of analytical grade.