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Aerosil 200 pharma

Manufactured by Evonik
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Sourced in Germany, United States

Aerosil 200 Pharma is a high-purity, synthetic amorphous silicon dioxide product. It is a fine, white, odorless, and tasteless powder. Aerosil 200 Pharma is designed to meet the purity requirements for use in pharmaceutical and dietary supplement applications.

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Lab products found in correlation

Amiodarone hydrochloride, by Sanofi (2 mentions) Glycerol, by Avantor (2 mentions) Avicel ph 101, by FMC Biopolymer (1 mentions) Opadry, by Colorcon (1 mentions) Polyplasdone xl, by Ashland (1 mentions) Vivapur 12, by JRS Pharma (1 mentions) Pearlitol 100sd, by Roquette (1 mentions) Tetraglycol, by Merck Group (1 mentions) Polyvinylpyrrolidone pvp k30, by Merck Group (1 mentions) Sorafenib tosylate, by Biosynth (1 mentions) Cremophor el, by Merck Group (1 mentions) Labrafil m 2125, by Gattefosse (1 mentions) Lauroglycol 90, by Gattefosse (1 mentions) Triethylamine, by Merck Group (1 mentions) Glycerin, by Daejung Chemicals (1 mentions) Transcutol p, by Gattefosse (1 mentions) Labrasol, by Gattefosse (1 mentions) Capryol 90, by Gattefosse (1 mentions) Peceol, by Gattefosse (1 mentions) Span 80, by Daejung Chemicals (1 mentions)

9 protocols using aerosil 200 pharma

1

Excipient Evaluation for DAP-CA Cocrystal

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DAP-CA cocrystal (99.9% purity) was obtained from Sun Pharm. Industries, Ltd. (Mumbai, India). Anhydrous lactose (Supertab 21AN) was obtained from DFE Pharma (Goch, Germany). Lactose monohydrate (Tablettose) was obtained from Meggle Pharma (Wasserburg, Germany). Microcrystalline cellulose (Avicel PH-101) was purchased from FMC biopolymer (Philadelphia, PA, USA). Microcrystalline cellulose (Vivapur 12) was obtained from JRS Pharma (Rosenberg, Germany). Mannitol (Pearlitol 100 SD) was obtained from ROQUETTE Pharma (Lestrem, France), crospovidone (Polyplasdone XL) was provided by Ashland (DA, USA), colloidal silicon dioxide (Aerosil 200 pharma) was purchased from Evonik (Essen, Germany), and magnesium stearate was purchased from FACI (Genova, Italy). Opadry was purchased from Colorcon (Stoughton, WI, USA). DAP amorphous (99.9% purity) and DAP-PH (99.9% purity) were provided by Dr. Reddy (Hyderabad, India), and Forxiga® 10 mg, a control agent, was provided by AstraZeneca Korea (Seoul, Korea).
Cho S., Lee J., Yoo Y., Cho M., Sohn S, & Lee B.J. (2021). Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers. Pharmaceutics, 13(1), 70.
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2

Pharmaceutical Excipient Formulations

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d-sorbitol (CE) was purchased from Carlo Erba. Polyethylene oxide, PEO(PolyoxN10, Dow Chemical, Midland, TX, USA), was donated. Glycerol (Glycerol, VWR, Radnor, PA, USA) was purchased. Colloidal anhydrous silica (Aerosil 200 Pharma, Evonik, Rheinfelden, DE, USA) was purchased. Amiodarone hydrochloride was donated from Sanofi, FR.
Roulon S., Soulairol I., Lavastre V., Payre N., Cazes M., Delbreilh L, & Alié J. (2021). Production of Reproducible Filament Batches for the Fabrication of 3D Printed Oral Forms. Pharmaceutics, 13(4), 472.
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3

Sorafenib Tosylate Formulation Development

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Sorafenib tosylate was purchased from BIOSYNTH Carbosynth (Compton, Newbury, United Kingdom). Cremophor EL, tetraglycol, triethylamine, and polyvinylpyrrolidone (PVP K 30) (average molecular weight 40 kDa) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Triacetin, isopropyl myristate (IPM), soybean oil, corn oil, tween 80, span 80, span 20, mineral oil, and glycerin were acquired from Daejung Chemicals Co. (Siheung, South Korea). Peceol, labrafil M 1994 CS, labrafil M 2125, labrasol, transcutol P, lauroglycol 90, capryol 90, and labrafac lipophile WL 1349 were obtained from Gattefossé (Saint-Priest Cedex, France). Capmul MCM and captex 355 were gifted from Abitec Corporation (Columbus, OH, USA). Propylene glycol, tween 20, olive oil, and phosphoric acid were purchased from Duksan Pure Chemical (Ansan, South Korea). Polyethylene glycol (PEG) 400 was purchased from Samchun Pure Chemical (Gyeonggi-Do, South Korea). Colloidal silica (Aerosil® 200 Pharma) was purchased from Evonik industries AG (Essen, Germany). Ethanol (EtOH) and high-performance liquid chromatography (HPLC)-grade acetonitrile (ACN) were purchased from Honeywell Burdick & Jackson® (Muskegon, MI, USA). All other chemicals used were of the analytical grade.
Fakhrai H., Dorigo O., Shawler D.L., Lin H., Mercola D., Black K.L., Royston I, & Sobol R.E. (1996). Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.. Proceedings of the National Academy of Sciences of the United States of America, 93(7), 2909-2914.
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4

Ibuprofen Powder and Tablet Formulation

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The materials used in this study included IBU as an API and excipients. API (≥98% GC grade) was purchased from Sigma-Aldrich (Millipore Sigma, St. Louis, MO, USA). Four excipients were used and blended with IBU to obtain powders and tablets in the concentration range tested. Lactose monohydrate (LM; granular; Meggle Pharma, MEGGLE Group, Wasserburg, Germany), microcrystalline cellulose (MCC; Vivapur® 102, JRS Pharma LP, Patterson, New York, NY, USA), colloidal silicon dioxide (C-SiO2) (Aerosil® 200 Pharma, Evonik Industries AG, Essen, Germany), and magnesium stearate (MgSt) (Mallinckrodt Inc., Raleigh, NC, USA) were used.
Villanueva-López V., Pacheco-Londoño L.C., Villarreal-González R., Castro-Suarez J.R., Román-Ospino A., Ortiz-Rivera W., Galán-Freyle N.J, & Hernandez-Rivera S.P. (2021). API Content and Blend Uniformity Using Quantum Cascade Laser Spectroscopy Coupled with Multivariate Analysis. Pharmaceutics, 13(7), 985.
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5

Sorbitol and Polyethylene Oxide Formulation

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D-Sorbitol Parteck SI150 (SI150) and Parteck SI200 (SI200) were donated from Merck, Darmstadt, Germany. D-Sorbitol (CE) was purchased from Carlo Erba, Italy and D-Sorbitol (GLT) was purchased from Glentham, Corsham, UK. Polyethylene oxide, Polyox N10 (PEO) was donated from Dow Chemical, Midland, TX, USA. Glycerol was purchased from VWR, Radnor, PA, USA. Colloidal anhydrous silica (Aerosil 200 Pharma) was purchased from Evonik, Rheinfelden, Germany, USA. Amiodarone hydrochloride was donated from Sanofi, France.
Roulon S., Soulairol I., Cazes M., Lemierre L., Payre N., Delbreilh L, & Alié J. (2021). D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine. Molecules, 26(10), 3000.
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6

Formulation Development of Tablet Binders

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Table 1 gives an overview of used binders. Different types of hyprolose were used. Table 2 lists their molecular weight and particle size. Additional applied substances were lactose monohydrate (Granulac® 200, Meggle, Wasserburg am Inn, Germany) as filler, silicium dioxide (Aerosil® 200 Pharma, Evonik, Hanau-Wolfgang, Germany) to improve flow properties, and magnesium stearate (LIGAMED® MF-2-V, Peter Greven Nederland C.V., Venlo, The Netherlands) as a lubricant for tableting.
Köster C., Pohl S, & Kleinebudde P. (2021). Evaluation of Binders in Twin-Screw Wet Granulation. Pharmaceutics, 13(2), 241.
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7

Formulation Development of Metoprolol Tartrate

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Metoprolol tartarate (MPT) was purchased from Esteve Quimica (Barcelona, Spain). Glyceryl behenate (GB, Compritol® 888 ATO) and glyceryl palmitostearate (GPS, Precirol® ATO 5) were obtained from Gattefosse (St. Priest, France). Magnesium stearate (Mg St) was purchased from ABC Chemicals (Wauthier-Braine, Belgium), colloidal silica dioxide (Aerosil® 200 Pharma) from Evonik (Hanau-Wolfgang, Germany), pancreatin from Sigma Aldrich (USA), sodium taurocholate from Prodotti Chimici e Alimentari (Basaluzzo, Italy) and egg phosphatidylcholine (LIPOID E PC S) from Lipoid (Steinhausen, Switzerland). All other reagents were of analytical grade. The quantitative composition of the formulations processed via the four different techniques is given in Table 1.
Aleksovski A., Van Bockstal P.J., Roškar R., Sovány T., Regdon G J.r., De Beer T., Vervaet C, & Dreu R. (2016). Comparison of metoprolol tartrate multiple-unit lipid matrix systems produced by different technologies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 88.
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8

Formulation and Characterization of Controlled-Release Tablets

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D-mannitol, D-sorbitol, magnesium stearate, bismuth(III) oxide and barium sulphate were purchased from Sigma–Aldrich (Poole, UK). Polyplasdone XL-10 (crospovidone) was obtained from ISP (Switzerland). Avicel PH102 (MCC) was obtained from FMC Biopolymer (Philadelphia, USA). Aerosil 200 Pharma (colloidal silicon dioxide) was obtained from Evonik Industries (Essen, Germany). A coating polymer Kollicoat IR (BASF, Germany) and a fluorescent dye riboflavin 5′-monophosphate sodium salt (Sigma-Aldrich, Pool, UK) were obtained for film coating work.
Dennison T.J., Smith J., Hofmann M.P., Bland C.E., Badhan R.K., Al-Khattawi A, & Mohammed A.R. (2016). Design of Experiments to Study the Impact of Process Parameters on Droplet Size and Development of Non-Invasive Imaging Techniques in Tablet Coating. PLoS ONE, 11(8), e0157267.
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9

Formulation and Evaluation of KCl-FHA Varnish

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KCl (AnalaR ® BDH, VWR International, Poole, England) and FHA 10% (w/w) were mixed with fully hydrogenated rosin (Foral ™ AX-E, Eastman Chemical BV, Capelle aan den IJssel, The Netherlands), hydrophilic fumed silica (Aerosil ® 200 Pharma, Evonik Industries AG, Rheinfelden, Germany) and absolute ethanol (Merck, Merck KGaA, Darmstadt, Germeny) (Table 1). The KCl-FHA varnish was placed into a capped syringe and stored at room temperature.
Three additional varnishes were prepared (Table 1) to investigate the effects of the ingredients of the KCl-FHA varnish: plain varnish (a mixture of fully hydrogenated rosin, hydrophilic fumed silica, and absolute ethanol), which served as control, KCl varnish (plain varnish containing 10% (w/w) KCl), and FHA varnish (plain varnish containing 10% (w/w) FHA). These varnishes were placed into capped syringes and stored at room temperature.
Lochaiwatana Y., Poolthong S., Hirata I., Okazaki M., Swasdison S, & Vongsavan N. (2015). The synthesis and characterization of a novel potassium chloride-fluoridated hydroxyapatite varnish for treating dentin hypersensitivity. Dental materials journal, 34(1).
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