Incb054329

Manufactured by Selleck Chemicals

INCB054329 is a laboratory equipment product. It is a solid small molecule inhibitor designed for use in scientific research. The core function of INCB054329 is to inhibit the enzymatic activity of specific molecular targets.

Automatically generated - may contain errors

Lab products found in correlation

Abbv744, by Selleck Chemicals (1 mentions) Arv 825, by Selleck Chemicals (1 mentions) Molibresib, by Selleck Chemicals (1 mentions) Birabresib, by Selleck Chemicals (1 mentions) Ms436, by Selleck Chemicals (1 mentions) Plx51107, by Selleck Chemicals (1 mentions) Pfi 1, by Selleck Chemicals (1 mentions) Cpi 203, by Selleck Chemicals (1 mentions)

2 protocols using incb054329

Pharmacological Screening of Compounds

Check if the same lab product or an alternative is used in the 5 most similar protocols

Compounds were sources from MedChem Express (unless noted) and dissolved at 10 mM in DMSO and vehicle controls used. A larger batch of INCB054329 was sourced from Selleckchem. The following compounds were used at 2 or 3 doses previously shown to have in vitro efficacy as per the referenced papers for: JQ-1 (Selleckchem), INCB054329, ABBV-744, ruxolitinib, baricitinib, flavopiridol, SEL120-34A, BI-1347, and paroxetine hydrochloride. Additional compounds tested were molibresib, alobresib, and apabetalone. For some experiments apabetalone and RVX-2157 were sent blinded by Resverogix. Compounds were given at the time of pro-inflammatory factor addition, except for experiments with baricitnib and INCB054329 where recovery of function was also assessed by addition 24 h following addition of inflammatory factors.

Mills R.J., Humphrey S.J., Fortuna P.R., Lor M., Foster S.R., Quaife-Ryan G.A., Johnston R.L., Dumenil T., Bishop C., Rudraraju R., Rawle D.J., Le T., Zhao W., Lee L., Mackenzie-Kludas C., Mehdiabadi N.R., Halliday C., Gilham D., Fu L., Nicholls S.J., Johansson J., Sweeney M., Wong N.C., Kulikowski E., Sokolowski K.A., Tse B.W., Devilée L., Voges H.K., Reynolds L.T., Krumeich S., Mathieson E., Abu-Bonsrah D., Karavendzas K., Griffen B., Titmarsh D., Elliott D.A., McMahon J., Suhrbier A., Subbarao K., Porrello E.R., Smyth M.J., Engwerda C.R., MacDonald K.P., Bald T., James D.E, & Hudson J.E. (2021). BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection. Cell, 184(8), 2167-2182.e22.

+ Open protocol

+ Expand

Comparative Analysis of BET Inhibitors

Cited 3 times

Check if the same lab product or an alternative is used in the 5 most similar protocols

Apabetalone (RVX-208; BET inhibitor, S7295), ARV-825 (BRD4 specific inhibitor, S8297), AZD-5153 6-hydroxy-2-naphthoic acid (BET/BRD4 inhibitor, S8344), CPI-203 (BET inhibitor, S7304), Molibresib (I-BET-762; BET inhibitor, S7189), (+)-JQ1 (BET inhibitor, S7110), INCB054329 (BET inhibitor, S8753), MS436 (BET inhibitor, S7305), Birabresib (OTX015; BET inhibitor, S7360), PLX51107 (a new BET inhibitor, S8739), and PFI-1 (PF-6405761; BRD2/BRD4 inhibitor, S1216) were purchased from Selleck.cn, and ZL0580 (a BRD4-specific inhibitor) was prepared as previously described (20 (link), 45 (link)). The structures and functions of these inhibitors are shown in Fig. 3A, Text S1 in the supplemental material (see also Selleck.cn [https://www.selleck.cn]), and Table 1 (20 (link), 41 (link), 46 (link)– (link)55 (link)).

Zhao Y., Niu Q., Yang S., Yang J., Zhang Z., Geng S., Fan J., Liu Z., Guan G., Liu Z., Zhou J., Hu H., Luo J, & Yin H. (2022). Inhibition of BET Family Proteins Suppresses African Swine Fever Virus Infection. Microbiology Spectrum, 10(4), e02419-21.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!