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Ge discovery ste pet scanner

Manufactured by GE Healthcare
Sourced in United States

The GE Discovery STE PET scanner is a medical imaging device used for positron emission tomography (PET) scans. It is designed to capture high-resolution images of the body's internal structures and functions. The scanner utilizes radioactive tracers to detect and measure the activity of cells within the body, providing valuable information for medical diagnosis and treatment planning.

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2 protocols using ge discovery ste pet scanner

1

PET Imaging of Dopamine D2/3 Receptors

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[18F]Fallypride, (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3[18F]fluoropropyl)-2,3-dimethoxybenzamide was produced in the radiochemistry laboratory attached to the PET unit at Vanderbilt University Medical Center, following synthesis and quality control procedures described by U.S. Food and Drug Administration IND 47,245. PET data were collected on a GE Discovery STE PET scanner (GE Healthcare). Serial scan acquisition was started simultaneously with a 5.0 mCi (185 MBq; Study 1 median specific activity = 5.33 mCi, SD = 0.111; Study 2 median specific activity = 5.32, SD = 0.264) slow bolus injection of DA D2/3 tracer [18F]fallypride (specific activity >3000 Ci/mmol). CT scans were collected for attenuation correction before each of the three emission scans, which together lasted ∼3.5 h with two breaks for subject comfort. Before the PET scan, T1-weighted magnetic resonance (MR) images (Turbo Field Echo [TFE] SENSE protocol; Act. TR = 8.9 ms, TE = 4.6 ms, 192 TFE shots, TFE duration = 1201.9 s, FOV = 256 × 256 mm, voxel size = 1 × 1 × 1 mm) were acquired on a 3T Intera Achieva whole-body scanner (Philips Healthcare).
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2

Radiolabeled Dopamine Transporter Tracer Protocol

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[18F]-FE-PE2I was produced by the Vanderbilt Radiochemistry Core laboratory under cGMP protocols. The synthetic preparation was carried out utilizing a Tracerlab FXFN reaction module (GE Healthcare) and was synonymous to a previously published preparation50 (link). Serial scan acquisition was started simultaneously with a slow bolus injection (mean = 4.63 ± 0.34 mCi; 171.31 ± 12.58 MBq) of the DAT tracer [18F]-FE-PE2I (specific activity = 2302 ± 1445 Ci/mmol). CT scans were collected for attenuation correction prior to the emission scan. FE-PE2I data were collected during one 61-min dynamic scan with acquisition times listed in Table S1. While previous human PET studies using FE-PE2I used 90 min dynamic scan acquisitions46 (link),48 (link), we chose the 61 min acquisition time to improve participant comfort given that the correlation between putamen FE-PE2I BPND collected after 61 and 90 min in 4 pilot subjects was extremely high (r = 0.997, mean percentage of BPND difference = 2.06 ± 1.72). All PET data were collected on a GE Discovery STE PET scanner (GE Healthcare, Milwaukee, USA).
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