Azd0364

Manufactured by Selleck Chemicals

Sourced in United States

AZD0364 is a chemical compound used in laboratory research. It is a small molecule that has been utilized in various experimental studies. The core function of AZD0364 is to serve as a tool for scientific investigation, but no further details about its intended use or applications can be provided in an unbiased and factual manner.

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Lab products found in correlation

Erastin, by Merck Group (1 mentions) Ulixertinib, by MedChemExpress (1 mentions) 3 methyladenine 3 ma, by Merck Group (1 mentions) Trolox, by Merck Group (1 mentions) U0126, by Cayman Chemical (1 mentions) Z vad fmk, by MedChemExpress (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Zstk474, by Selleck Chemicals (1 mentions)

2 protocols using azd0364

Screening Chemical Inhibitors for Cell Death

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U0126 was obtained from Cayman Chemical (Ann Arbor, MI). Fer-1, MEK inhibitor I, (Z)-4-hydroxytamoxifen (Tamoxifen), DFO, Trolox, and 3-methyladenine (3-MA) and erastin were obtained from Merck Millipore (Burlington, MA). RSL3, Z-VAD-FMK, and Ulixertinib were obtained from MedChemExpress (Monmouth Junction, NJ). Necrostatin 2 racemate (Nec-1s), pluripotin, and AZD0364 were obtained from Selleck Chemicals (Huston, TX). The chemical inhibitor library for several enzymes (SCADS inhibitor kits) was kindly gifted by the Molecular Profiling Committee.

Tsuruta K., Matsuoka M., Harada S., Enomoto A., Kumagai T., Yasuda S., Koumura T., Yamada K.I, & Imai H. (2023). Slowly progressive cell death induced by GPx4-deficiency occurs via MEK1/ERK2 activation as a downstream signal after iron-independent lipid peroxidation. Journal of Clinical Biochemistry and Nutrition, 74(2), 97-107.

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Preparation of AZD0364 and ZSTK474 Stock Solutions

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AZD0364 and ZSTK474 were purchased from Selleck Chemicals (Selleckchem, Houston, TX, USA) and Merck Millipore (Billerica, MA, USA), respectively. The stock solutions were prepared at 10 mM in dimethyl sulfoxide (DMSO, Merck Millipore) and were stored at −80 °C until use.

Jasek-Gajda E., Jurkowska H., Jasińska M, & Lis G.J. (2020). Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells. Antioxidants, 9(7), 633.

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