Atazanavir was obtained as a generous gift from Sun Pharmaceutical Industries Limited (Gurgaon, India). Labrafil® M1944CS, Labrafil® M2125CS, LabrafacTM WL1349, LabrafacTM PG, LauroglycolTM 90, CapryolTM PGMC, Compritol® 888ATO, Precirol® ATO 5, Solutol HS15®, Glyceryl monostearate, Gelucire® 44/14, and Gelucire® 43/10 were acquired by Gattefosse (Saint Priest, France). Capmul® PG-12 EP/NF, Captex® 100, and Captex® 300 were obtained from Abitech Corporations (Cleveland, OH, USA). The surfactants like span 20, tween 80, and tween 20 were procured from Merck (Hohenbrunn, Germany). Poloxamer 188, Poloxamer 407, and Cremophor RH 40 were acquired from BASF (Mumbai, India). Sesame oil, canola oil, and castor oil were acquired from the central drug house (Mumbai, India). Water, methanol, and acetonitrile for HPLC were procured from Fischer Scientific Co. (Mumbai, India). Purified water used for all experiments was obtained from Milli Q Plus (Millipore, MA, USA). Rest of the chemicals and reagents were procured from S.D. Fine Chemicals Ltd. (Mumbai, India). Freshly prepared buffer solutions were used for all experiments.
Labrafac pg
Manufactured by Gattefosse
Sourced in France, India, Germany
Labrafac PG is a medium-chain triglyceride (MCT) suitable for use as a pharmaceutical excipient. It is a clear, oily liquid composed of saturated fatty acids. Labrafac PG is used as a solvent, emulsifier, and co-emulsifier in various pharmaceutical and cosmetic formulations.
Automatically generated - may contain errors
Lab products found in correlation
Labrafil m 1944 cs, by Gattefosse (12 mentions)
Labrasol, by Gattefosse (11 mentions)
Capryol 90, by Gattefosse (7 mentions)
Lauroglycol 90, by Gattefosse (6 mentions)
Transcutol p, by Gattefosse (6 mentions)
Transcutol hp, by Gattefosse (6 mentions)
Labrafil m 2125 cs, by Gattefosse (5 mentions)
Cremophor el, by BASF (5 mentions)
Compritol 888 ato, by Gattefosse (4 mentions)
Tween 80, by Merck Group (4 mentions)
Peceol, by Gattefosse (4 mentions)
Plurol oleique cc 497, by Gattefosse (4 mentions)
Poloxamer 407, by BASF (3 mentions)
Labrafac lipophile wl 1349, by Gattefosse (3 mentions)
Capryol pgmc, by Gattefosse (3 mentions)
Tween 20, by Merck Group (3 mentions)
Acetonitrile, by Merck Group (3 mentions)
Gelucire 44 14, by Gattefosse (2 mentions)
Poloxamer 188, by BASF (2 mentions)
Precirol ato 5, by Gattefosse (2 mentions)
25 protocols using labrafac pg
1
Atazanavir Solubility Optimization
2
Optimizing Enzymatic Assay Conditions
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Stearic acid Grade I ! 98.5% (GC), Tween Ò 80 (Hydrophiliclipophilic balance, HLB 15), deoxycholic acid sodium salt ! 96% (SDC, HLB 16), Span Ò 60 (HLB 4.7), alkaline phosphatase from bovine intestinal mucosa (ALP, 7165 units/mg protein), potassium phosphate monobasic (KH 2 PO 4 ) 99.5%, protamine sulfate salt from salmon grade X, 5.1 kDa, sodium polyphosphate (Graham's salt, PP), sodium tripolyphosphate 85% (TPP), phosphatase inhibitor cocktail 2 (PIC), Triton X-100 for molecular biology, ammonium molybdate tetrahydrate 81-83%, malachite green (MLG) oxalate salt 90% and resazurin sodium salt were received from Sigma Aldrich, Austria. Kolliphor Ò HS 15 (Solutol, HLB 16) and Lumogen F 300 red (LgR) were received from BASF, Germany. 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) ! 99.5% was obtained from ROTH GmbH, Germany. RIPA lysis and extraction buffer was purchased from Thermo Scientific, Austria. Pluronic Ò F-68 (Lutrol, HLB > 24) was obtained from Applichem GmbH, Germany. Labrafac TM PG (propylene glycol dicaprylocaprate, L-PG) and Labrafac TM lipophile WL 1349 (medium chain triglycerides, L-MCT) were provided by Gattefossé, France. All other reagents were of analytical grade and obtained from commercial sources.
3
Lipid-based Delivery System for Ropivacaine and Meloxicam
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Transcriptional transactivator peptide–polyethylene glycol2000–distearoyl phosphoethanolamine (TAT–PEG2000–DSPE) was prepared by our lab as reported before (Wang et al., 2016 (link)). Ropivacaine, meloxicam,Tween-80, and stearic acid were purchased from Sigma Aldrich (St. Louis, MO). Polyoxyl castor oil (Cremophor ELP) was donated by BASF (Ludwigshafen, Germany); soybean phospholipids (SPCs) were purchased from Taiwei Pharmaceuticals (Shanghai, China); Labrafac PG (propylene glycol dicaprylocaprate) was a kind offer from Gattefossé (Gennevilliers, France). All other reagents and solvents were analytical or high-performance liquid chromatography (HPLC) grade. Kunming mice (4–6 weeks old, 18–22 g weight) were purchased from the Medical Animal Test Center of Shandong University. The animal experiments followed the guidance of the National Institutes of Health (NIH) for the care and use of laboratory animals.
4
Formulation and Evaluation of Enzalutamide Soft Capsules
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ENZ was purchased from MSN Labratories Private Ltd. (Telangana, India). The Xtandi® soft capsule, TPGS and MCT oil were supplied by Boryung Corporation (Seoul, Republic of Korea). Labrafac PG, Peceol, Labrasol, Capryol 90, Transcutol P, and Lauroglycol 90 were obtained from Gattefosse (St. Priest, France). Cremophor EL, Cremophor RH60, and Solutol HS15 were supplied by BASF (Ludwigshafen, Germany). Castor oil, coconut oil, olive oil, sesame oil, sunflower oil, corn oil, soybean oil, cotton seed oil, peanut oil, polysorbate 80, ammonium acetate, acetone, and acetonitrile were purchased from Daejung Co. Ltd. (Siheung, Republic of Korea). Sodium carboxymethyl cellulose was purchased from Duksan Pure Chemical (Ansan, Republic of Korea). All other chemicals used were of analytical grade.
5
Comprehensive Topical Formulation Development
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CZP was kindly supplied by Delta Pharm Co., Egypt. Labrafil isostearique, labrafil M 1944 CS, plurol oleique CC 497, peceol TM, lauroglycol 90, transcutol P and labrafac PG were kindly provided by Gattefossé Co., France. Isopropyl palmitate (IPP), oleic acid, Pluronic® F-127 (PF127) were purchased from Sigma Aldrich Co., USA. Glycerin, paraffin oil, tween 20, tween 80, propylene glycol (PG), polyethylene glycol 400 (PEG 400), ethanol, sudan III and methylene blue were purchased from El-Nasr Pharmaceutical Chemicals Co., Egypt. Eucalyptus oil was purchased from Katto Flavors and Fragrance co., Egypt. Triacetin was purchased from Euromedex Co., France. Pluronic® F-68 (PF68) was purchased from Caisson Laboratories, USA. Peppermint oil was purchased from V. Mane Fils Co., France. Other chemicals and solvents were of analytical grade.
6
Formulation and Characterization of Nano-Emulsion
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XH was obtained as gift sample from Hopsteiner Trading (Zhuhai) Co., Ltd., Zhuhai, China. GUG, A-200, polyethylene glycol (PEG) 200, Tween 80 (T80), PTN, lactose monohydrate (LM), magnesium stearate (MgS), microcrystalline cellulose PH102 (MCC) was purchased from Lobacheime Pvt. Ltd., Mumbai, India. SXDP was gifted by Grace GmbH and Co KG, Mumbai, India. Peanut oil, cotton seed oil, eucalyptus oil, olive oil, castor oil was purchased from Global Merchants, Navi Mumbai, India. Hydrochloric acid (HCl) was acquired from Central Drug House, New Delhi, India. Labrafac PG (LPG), Labrafil M1944CS (LMCS) and Transcutol P (TP) were gifted by Gattefosse, Mumbai, India. Capmul MCM EP/NF (CMCM) was gifted by Abitec Corp., Mumbai, India. Methanol and ortho-phosphoric acid (OPA) High Performance Liquid Chromatography (HPLC) grade were acquired from Rankem, Mumbai, India. Distilled water (DW) was used throughout the study. The instruments used in this study were the same as reported in our previous study [37 (link)].
7
Development and Characterization of Lipid-based Formulations
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OLA was supplied by ScinoPharm Taiwan Ltd. (Tainan, Taiwan). Labrafil® M 1944 CS, Labrafac® PG, Labrasol®, Transcutol® HP and Plurol Oleique® CC 497 were supplied by Gattefosse (St. Priest, France). Cotton seed oil, Span 80, isopropyl myristate and PEG 400 were obtained from Daejung Co. Ltd. (Siheung, Republic of Korea). Oleic acid and Tween 80 were purchased from Duksan Co. Ltd. (Ansan, Republic of Korea). Mineral oil, Capmul® MCM EP/NF and Kolliphor® EL (known as Cremophor EL) were obtained from Samchun Chemicals Co. (Pyeongtaek, Republic of Korea), ABITEC Corp. (Columbus, OH, USA) and BASF (Ludwigshafen, Germany), respectively. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) was purchased from Sigma-Aldrich Co. (St. Louis, MO, USA). All chemicals and solvents used were of reagent or HPLC grade.
8
Simvastatin Lipid Nanoparticle Formulation
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Simvastatin was gifted by Tocris Bio-Techne Mumbai, India. Poloxamer 407 was gifted by BASF, India. Alendronate sodium, D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) were purchased from Sigma-Aldrich Mumbai India. Peanut Oil, Soyabean Oil, Olive Oil, Sesame Oil and Cottonseed Oil were purchased from Research Lab Fine Chem Industries. Labrafil M 2125CS, Capryol PGMC, Labrafac PG, Labrasol and Labrafil M 1944CS was gifted by Gattefosse India. All other reagents used were of analytical reagent grade and were used without further purification.
9
Carvedilol Solubility Enhancement Formulation
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Carvedilol was obtained from Dr. ABIDI’s Pharmaceutical laboratory. Labrafil M 1944CS, and Labrafac PG were gifts from the GATTEFOSSE Company (France). Oleic acid and Span 20 were obtained from Merck (Germany) Inc.; also, hydroxypropyl methylcellulose (HPMC) and Poloxamer were obtained from Sigma-Aldrich Corporation. Dialysis bag was purchased from the Toba Azema Co. Tehran, Iran.
10
Quercetin-Loaded Nanoemulsion Formulation
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Quercetin was purchased from Himedia, Mumbai. Poloxamer 407, Poloxamer 188 were purchased from Sigma Aldrich, Bangalore, India. Labrafac PG®, Labrasol®, Carbitol®, Transcutol HP® and Capryol 90® were obtained as gift samples from Gatte Fosse, Mumbai, India. Cremophor EL®, Lutrol E400, Carbopol 934P, and Lutrol E600 were obtained as gift samples from BASF Corporation, Mumbai, India. Xanthan gum and Gellan gum were purchased from Triveni Chemicals, Vapi, Gujarat, India. Cinnamon oil and Palm oil were purchased from Genuine Chemical Co., Mumbai. Triacetin, Isopropyl myristate and Castor oil was from Himedia Laboratories Pvt. Ltd., Mumbai, India. Sesame oil was from National Chemicals, Gujarat, India. Migliyol was from Peter Cremer, Hamburg, Germany. Tween 80 and Tween 60 were purchased from Nice chemicals Pvt. Ltd., Kochi and Sisco Research Laboratories Pvt. Ltd., Mumbai, India. Tween 20 and Glycerol were from Merck Specialities Pvt. Ltd., Mumbai, India respectively. Span 80 was from Suvidhinath Laboratories, Baroda. Ethylene glycol was procured from Loba Chemie Pvt. Ltd., Mumbai, India. All other chemicals and reagents were of laboratory grade.
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