Agilent directdrive

Manufactured by Agilent Technologies

Sourced in United States, United Kingdom

The Agilent DirectDrive is a lab equipment product that provides direct drive technology for precise control and high performance. It is designed to offer accurate and reliable control of motion-based applications.

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Agilent DirectDrive scanner (5 citations) Agilent DirectDrive console (4 citations)

4 protocols using agilent directdrive

Postmortem Macaque Diffusion Imaging at 7T

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We used six high-quality postmortem macaque (age range, 4 to 16 years) datasets in this study, as described previously (12 (link)). These data were acquired at 7T using a Agilent DirectDrive console (Agilent Technologies, Santa Clara, CA, USA) using a 2D diffusion-weighted spin-echo protocol with single-line readout, with 16 b = 0 volume, 128 volumes acquired with b = 4000 s/mm², and an isotropic spatial resolution of 0.6 mm. Protocol details are summarized in table S2. Nonlinear transformations to the macaque standard space (F99) (75 (link)) were estimated using FSL’s FNIRT (74 ) based on the FA maps.

Warrington S., Thompson E., Bastiani M., Dubois J., Baxter L., Slater R., Jbabdi S., Mars R.B, & Sotiropoulos S.N. (2022). Concurrent mapping of brain ontogeny and phylogeny within a common space: Standardized tractography and applications. Science Advances, 8(42), eabq2022.

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In vivo Diffusion MRI of Mouse Brain

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In vivo diffusion MRI experiments were performed on a 4.7-T Agilent DirectDrive^™ small-animal MRI system (Agilent Technologies, Santa Clara, CA) equipped with Magnex/Agilent HD imaging gradient coil (Magnex/Agilent, Oxford, UK) with pulse gradient strength up to 58 G/cm and a gradient rise time ≤ 295 μs. After anesthetized using 1% isoflurane/oxygen, mice were placed in a custom-made head holder. The rate of respiration and rectal temperature, at 37 °C, was monitored and controlled by a small animal physiological monitoring and control unit (SAII Inc., NY). An actively-decoupled volume (transmit)/surface (receive) coil pair was used for MR excitation and signal reception. All image slices were acquired based on previously reported procedures (Sun et al., 2008 (link)) to plan for the final-targeted slice showing a transverse view of mouse brain with two optic nerves, as nearly as orthogonal to image slice as possible. A multi-echo spin-echo diffusion-weighted sequence (Tu et al., 2010 ) and a 25-direction diffusion-encoding scheme combined with one b = 0 were employed and MR acquisition parameters were TR 1.5 sec, TE 37 ms, Δ 18 ms, δ 6 ms, max. b-value 2200 s/mm², slice thickness 0.8 mm, in-plane resolution 117 μm × 117 μm (before zero-filled). The total acquisition was approximately 2 hour, 20 minutes.

Chiang C.W., Wang Y., Sun P., Lin T.H., Trinkaus K., Cross A.H, & Song S.K. (2014). Quantifying white matter tract diffusion parameters in the presence of increased extra-fiber cellularity and vasogenic edema. NeuroImage, 101, 310-319.

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Small-Animal Brain Diffusion MRI Protocol

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MRI experiments were performed on a 4.7 T Agilent DirectDrive™ small-animal MRI system (Agilent Technologies, Santa Clara, CA) equipped with Magnex/Agilent HD imaging gradient coil (Magnex/Agilent, Oxford, UK) with pulse gradient strength up to 58 G/cm and a gradient rise time ≤295 μs. Mice were anesthetized with 1% isoflurane in oxygen and placed in a custom made 3-point immobilization head holder. Breathing rate was monitored, and body temperature was maintained at 37 °C with a small animal physiological monitoring and control unit (SA Instruments, Stony Brook, NY). An actively decoupled volume (transmit)/surface (receive) coil pair was used for MRI excitation and signal reception. Diffusion-weighted MRI data was acquired with a transverse slice of mouse brain with two optic nerves, as nearly orthogonal to the image slice as possible. A multi-echo spin-echo diffusion-weighted sequence [25 (link)] with an icosahedral 25-direction diffusion-encoding scheme [26 (link)] combined with one b = 0 was employed and MR acquisition parameters were TR of 1.5 s, TE of 37 ms, time between gradient pulses (Δ) of 18 ms, gradient pulse duration (δ) of 6 ms, maximum b-value of 2200 s/mm² (each encoding direction has a unique b-value), slice thickness of 0.8 mm, and in-plane resolution of 117 μm².

Lin T.H., Chiang C.W., Perez-Torres C.J., Sun P., Wallendorf M., Schmidt R.E., Cross A.H, & Song S.K. (2017). Diffusion MRI quantifies early axonal loss in the presence of nerve swelling. Journal of Neuroinflammation, 14, 78.

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In Vivo Longitudinal Brain Imaging

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MEMRI was performed immediately after MnCl₂ administration on a 4.7 T Agilent DirectDrive small-animal MRI system (Agilent Technologies, Santa Clara, CA) equipped with Magnex/Agilent HD image gradient coil (Magnex, Oxford, UK) with pulse gradient strength up to 58 G/cm and a gradient rise time ≤ 295 µs. Mice were anesthetized by 1.5% isoflurane/oxygen. During experiments, respiratory rate and body temperature were monitored using a MR compatible animal monitoring system (SA Instrument, Inc., Stony Brook, NY, US) and maintained at 130 – 150 breaths/min and 37°C with a regulated circulating warm water pad underneath mouse body along with regulated warm air blown into the magnet bore, respectively. A pair of 8-cm diameter volume (transmit) and 1.7-cm diameter surface (receive) active-decoupled coils were used.
A standard 3D gradient echo sequence was employed for T1-weighted (T1W) image of the whole mouse brain with the following parameters: repetition time (TR) = 15 ms, echo time (TE) = 2.63 ms, flip angle = 20°, number of averages = 16, field-of-view (FOV) = 15 × 15 × 22 mm³, matrix size = 128 × 128 × 64 (zero-filled to 256 × 256 × 128), acquisition time = 32.8 minutes. Ten successive sets of 3D-T1W image were captured approximately from 0.55 – 5.5 hours post-injection.

Lin T.H., Kim J.H., Perez-Torres C., Chiang C.W., Trinkaus K., Cross A.H, & Song S.K. (2014). Axonal transport rate decreased at the onset of optic neuritis in EAE mice. NeuroImage, 100, 244-253.

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