Eight-weeks after AMI, upon anesthesia induction and mechanical ventilation as previously described, closed-chest LV pressure-volume (PV) recordings were performed with a 5-Fr pigtail multi-segment pressure-volume conductance catheter (Ventri-Cath™ 507; Millar Instruments, Inc., Houston, TX) inserted through the femoral artery and guided to the LV apex with a 7-Fr 90 cm sheath (Cordis®, Miami Lakes, FL). Evaluation of load independent parameters was performed by transient occlusion of the inferior vena cava with a 25 mm-diameter balloon catheter (NuCLEUS™, NuMED™, Hopkinton, NY) with ventilation suspended at end-expiration. Cardiac output was measured continuously by thermodilution using a Swan-Ganz catheter (Edwards LifeSciences™, CL) inserted through the right internal jugular vein (8-Fr). Data was continuously acquired and recorded with the PowerLab 16/35 16-channel acquisition system, and analyzed offline using the LabChart 7 Pro software (ADInstruments, Oxford, UK). Volume signal was calibrated for parallel conductance by 10 ml 10% saline injection and for slope factor α by simultaneous measurement of cardiac output. Volume data was calibrated for swine body surface area according to corrections for mini-pig strains (18 (link)). End-systolic and end-diastolic PV relationships were obtained by linear fitting and exponential fitting with a pressure asymptote, respectively.
Ventri cath 507
Manufactured by Millar
Sourced in United States
The Ventri-Cath™ 507 is a medical device used for cardiac catheterization procedures. It is a sterile, single-use catheter designed for insertion into the cardiovascular system.
Automatically generated - may contain errors
Lab products found in correlation
Labchart pro, by ADInstruments (2 mentions)
Mpvs ultra pv loop system, by Millar (2 mentions)
Iox v1, by EMKA Technologies (2 mentions)
Labchart 7 pro software, by ADInstruments (1 mentions)
Swan ganz catheter, by Edwards Lifesciences (1 mentions)
Labchart v7, by ADInstruments (1 mentions)
Powerlab 16 30 ml880, by ADInstruments (1 mentions)
Labchart 7 pro, by ADInstruments (1 mentions)
Mpvs ultra pressure volume loop system, by Millar (1 mentions)
10 protocols using ventri cath 507
1
Pressure-Volume Analysis of Swine Heart
2
Invasive Hemodynamic Evaluation of Canine Cardiac Function
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All dogs were placed in left lateral recumbency, and the right common carotid artery was exposed from the adjacent tissue, and a 6-Fr sheath was introduced into the lumen. A conductance catheter (Ventri-Cath-507, Millar Instruments, Houston, TX, USA) was inserted into the LV through the sheath being guided by fluoroscopy. The analysis of real-time pressure-and-volume loop data was conducted using the Micro-Tip Pressure-Volume Ultra Foundation System (MPVS-Ultra-S, AD Instruments, Dunedin, New Zealand), PowerLab hardware (ML880 PowerLab 16/30, AD Instruments), and LabChart Pro software (LabChart v7, AD Instruments). LV end-diastolic pressure and Tau were calculated from 10 consecutive pressure-and-volume loops. Tau was measured according to the method of Weiss et al. [22 (link)]. The values of Emax and stiffness constant β were determined using the previously described method [23 (link)]. Emax was measured by linear regression of the end-systolic pressure-volume relation (EDPVR) during transient caval occlusions from six successive pressure-volume loops [24 (link)]. Stiffness constant β was obtained using the exponential equation of the EDPVR during the same procedure as Emax [25 (link)] as follows:
where EDP is the end-diastolic pressure, EDV is end-diastolic volume, and A is the curve-fitting constant.
where EDP is the end-diastolic pressure, EDV is end-diastolic volume, and A is the curve-fitting constant.
3
Pressure-Volume Catheter Instrumentation
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A bolus of 10 000 IU heparin was given before instrumentation. For arterial access, the left femoral artery was punctured and a 9F sheath was placed in Seldinger technique. This access was used to position a 5F micromanometertipped pressure-volume catheter (Ventri-Cath 507; Millar Instruments, Houston, TX) in the LV under fluoroscopic guidance. The catheter was connected to the MPVS Ultra Pressure-Volume Loop system (Millar Instruments), and data were recorded using Labchart 7 Pro (ADInstruments Europe, Oxford, United Kingdom). Before introduction, the catheter was pressure-calibrated in a 37°C water tank. Calibration was rechecked after removal of the catheter. Stroke work; systolic, diastolic, and end-diastolic pressure; and dP/dtmax were calculated from the recordings using Labchart and a dedicated, MATLAB-based (MathWorks, Eindhoven, the Netherlands) script (mloops; JU Voigt, Leuven, Belgium).
4
Hemodynamic Changes in Right Ventricular Function
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The heart rate, the mean PA pressure (mPAP), cardiac output, and blood saturation were measured at baseline (T0), at T6, and at 10 weeks (T10). A pressure-volume loop analysis of the RV was performed at T6 and T10 with a conductance VentriCath 507 (Millar Instruments, Houston, Tex).
5
Invasive Pressure Waveform Measurement
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After proper calibration, a Millar pressure catheter (Ventri Cath 507), which was connected to an MPVS Ultra PV loop system (Millar, Houston, Texas, USA), was advanced into the LV using a guide catheter. Pressure waveforms were recorded using a data acquisition system (LabChart Pro, ADInstruments, Colorado Springs, CO, USA).
6
Invasive Cardiac Hemodynamic Measurement
7
Invasive Cardiac Function Monitoring
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A 5F conductance catheter (Ventri-Cath 507, Millar Inc., Houston, TX) was placed retrogradely across the pulmonic valve into the right ventricle (RV) (RV hearts, N = 8), or across the aortic valve into the left ventricle (LV) (LV hearts, N = 8), for continuous recording of ventricular pressure, volume, and function data (Figure 1). Catheter pressure calibration was performed using a hand-held manometer, and volume calibration was carried out following measurement of blood conductivity. The maximum (dP/dt maximum) and minimum (dP/dt minimum) rate of pressure change within the ventricle were used to assess systolic and diastolic function, respectively. Cardiac output was calculated using the stroke volume and heart rate measured with the conductance catheter. All parameters were recorded continuously and analyzed using LabChart 7 Pro Version 7.2.5 (ADInstruments Inc., Colorado Springs, CO).
8
Cardiac Function Assessment Post-Transplant
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Global cardiac function was evaluated by cardiac output measurements using the pulmonary artery catheter and the traditional thermodilution technique. CI was derived as the ratio between cardiac output and body surface area. RV function was assessed with the same catheter using RV Stroke Work Index (RVSWI). LV function was assessed using a conductance catheter (Ventri-Cath 507S; Millar Inc, Houston, TX). Data were collected and analyzed using IOX v1.8.9.13 software (EMKA Technologies Inc.). All assessments were performed at baseline and at 3 hours of reperfusion posttransplant. Percent recovery (%) was then calculated relative to baseline values.
9
Evaluation of Left Ventricular Function
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The left ventricle’s functional parameters were measured using a conductance catheter (Ventri-Cath-507S, Millar Inc, Houston, TX) that had been calibrated according to the manufacturer’s instructions to record pressure-volume loops and relationships using IOX v1.8.9.13 software (EMKA Technologies Inc., Falls Church, VA). Volume-dependent measurements (i.e., stroke work, maximum and minimum rate of developed pressure) were collected under steady loading conditions aimed at maintaining a left atrial pressure of 8 mmHg, while volume-independent measurements (i.e., preload recruitable stroke work) were collected by intermittently decreasing left atrial loading (19 (link)).
10
Cardiac Function Evaluation in Transplantation
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Global function was evaluated by cardiac output measurements using the thermodilution technique. Cardiac index (CI) was then calculated as the ratio between cardiac output and body surface area. Right ventricular (RV) function was assessed using the RV stroke work index. LV function was assessed using a conductance catheter (Ventri-Cath-507S, Millar Inc, Houston, TX) calibrated according to the manufacturer's instructions to record pressure-volume loops and relationships using the IOX v1.8.9.13 software (EMKA Technologies Inc, Falls Church, VA). Evaluations were performed at baseline, after weaning from NRP, and at 2 and 3 hours after opening the aortic cross-clamp (post-transplant reperfusion).
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