FB23-2 (Selleck, China) is an inhibitor that directly binds to FTO and selectively inhibits the m6A demethylase activity of FTO in mammalian cells [16] (link). Ferrostatin-1 (fer-1, Selleck, China) is an effective and selective ferroptosis inhibitor, while erastin (Selleck, China) is a ferroptosis activator that acts on mitochondrial VDAC in cancer cells [17] (link). The three drugs were dissolved in dimethyl sulfoxide (DMSO) and stored at -80 °C. The NPC cells were treated with 10 μmol of FB23-2, 1 μmol of Fer-1, or 10 μmol of erastin in a medium containing 10% of FBS for 24–72 h, and the corresponding concentration of DMSO was used as a control.
Fb23 2
Manufactured by Selleck Chemicals
Sourced in China, United States
The FB23-2 is a laboratory equipment product. It is designed for use in research and analytical applications. The core function of the FB23-2 is to perform specific tasks related to laboratory procedures. No further details are available for this product at this time.
Automatically generated - may contain errors
Lab products found in correlation
Ferrostatin 1 fer 1, by Selleck Chemicals (1 mentions)
Erastin, by Selleck Chemicals (1 mentions)
Rapamycin, by Selleck Chemicals (1 mentions)
Selinexor kpt 330, by Selleck Chemicals (1 mentions)
Meclofenamic acid, by Selleck Chemicals (1 mentions)
3 methyladenine 3 ma, by Selleck Chemicals (1 mentions)
2 protocols using fb23 2
1
Targeting FTO and Ferroptosis in NPC
2
Inhibitors and Activators in FTO Demethylase
Check if the same lab product or an alternative is used in the 5 most similar protocols
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The inhibitors and activators used in this paper were as follows: meclofenamic acid (MA) (Selleck, Houston, TX, USA, #S4295) and FB23-2 (Selleck, #S8837), two FTO demethylase activity inhibitors; Selinexor (KPT-330) (Selleck, #S7252), a selective CRM-1/XPO-1 inhibitor; Rapamycin (Selleck, #S1039), an autophagy activator; 3-Methyladenine (3-MA) (Selleck, #S2767), an autophagy inhibitor.
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