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Monoethyl fumarate

Manufactured by Merck Group
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Monoethyl-fumarate is a chemical compound used in various laboratory applications. It is a colorless, crystalline solid with a molecular formula of C6H8O4. The core function of Monoethyl-fumarate is to serve as a reagent or an intermediate in chemical synthesis and analysis processes.

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Lab products found in correlation

Dimethyl alpha ketoglutarate, by Merck Group (2 mentions) Succinate, by Merck Group (2 mentions) Dimethyl fumarate, by Merck Group (2 mentions) Monoethyl succinate, by Merck Group (2 mentions) Dimethyl succinate, by Merck Group (2 mentions) Diethyl malate, by Merck Group (1 mentions)

3 protocols using monoethyl fumarate

1

Evaluating Diethyl Malate and Mono-ethyl Fumarate Effects on HEK-293T Cell Viability

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FH was knocked out from HEK-293T cells, and after 48 h, 1000 cells/well were seeded in white 96-well plates for an additional 24 h. Following that, the cells were treated with DMSO (control), 250 µM diethyl malate (Sigma Aldrich, #W237418), or 250 µM mono-ethyl fumarate (Sigma Aldrich, #12842225G). The metabolites were added twice a day for a total of three days. Cell viability was measured using the Cell Titer-Glo kit, and luminescence was measured with Cytation 3 Multi-Mode Reader.
Solaimuthu B., Lichtenstein M., Hayashi A., Khatib A., Plaschkes I., Nevo Y., Tanna M., Pines O, & Shaul Y.D. (2022). Depletion of Fumarate Hydratase, an Essential TCA Cycle Enzyme, Drives Proliferation in a Two-Step Model. Cancers, 14(22), 5508.
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2

Succinate and Fumarate Derivatives

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Succinate (S9512, Sigma), monoethyl-Succinate (475505, Sigma), dimethyl-Succinate (112755, Sigma), monoethyl-fumarate (128422, Sigma), dimethyl-fumarate (242926,Sigma), and dimethyl-alpha-ketoglutarate (349631, Sigma) were obtained from Sigma Aldrich.
Sulkowski P.L., Sundaram R.K., Oeck S., Corso C.D., Liu Y., Noorbakhsh S., Niger M., Boeke M., Ueno D., Kalathil A.N., Bao X., Li J., Shuch B., Bindra R.S, & Glazer P.M. (2018). Krebs Cycle-Deficient Hereditary Cancer Syndromes are Defined by Homologous Recombination DNA Repair Defects. Nature genetics, 50(8), 1086-1092.
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3

Succinate and Fumarate Derivatives

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Succinate (S9512, Sigma), monoethyl-Succinate (475505, Sigma), dimethyl-Succinate (112755, Sigma), monoethyl-fumarate (128422, Sigma), dimethyl-fumarate (242926,Sigma), and dimethyl-alpha-ketoglutarate (349631, Sigma) were obtained from Sigma Aldrich.
Sulkowski P.L., Sundaram R.K., Oeck S., Corso C.D., Liu Y., Noorbakhsh S., Niger M., Boeke M., Ueno D., Kalathil A.N., Bao X., Li J., Shuch B., Bindra R.S, & Glazer P.M. (2018). Krebs Cycle-Deficient Hereditary Cancer Syndromes are Defined by Homologous Recombination DNA Repair Defects. Nature genetics, 50(8), 1086-1092.
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