Automated hematology analyzer

Manufactured by Sysmex

Sourced in Japan

The automated hematology analyzer is a laboratory instrument designed to perform comprehensive blood cell analysis. It automates the process of counting and differentiating various types of blood cells, providing accurate and reliable data to support clinical decision-making.

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Lab products found in correlation

Xp 300, by Sysmex (3 mentions) High performance liquid chromatography (hplc), by Bio-Rad (2 mentions) Rpmi 1640 medium, by Thermo Fisher Scientific (2 mentions) Au5400 automatic analyzer, by Olympus (1 mentions) Automated chemistry analyzer, by Hitachi (1 mentions) Qualigent crp, by Sekisui (1 mentions) Ack lysis buffer, by Lonza (1 mentions) Rt 2100c microplate reader, by Rayto (1 mentions) Sodium citrate, by BD (1 mentions) Crp xl, by Merck Group (1 mentions) Anti cd61, by Beckman Coulter (1 mentions) Kaluza 2, by Beckman Coulter (1 mentions) Anti p selectin, by BioLegend (1 mentions) Anti fibrinogen, by Agilent Technologies (1 mentions) Adenosine diphosphate (adp), by Merck Group (1 mentions) Fc500 flow cytometer, by Beckman Coulter (1 mentions) Crp ul assay, by Fujifilm (1 mentions) Au400, by Olympus (1 mentions) Xn 9000, by Sysmex (1 mentions) Xe 5000, by Sysmex (1 mentions)

Close spelling variants of this product

Sysmex XN automated hematology analyzers PocH-100i Automated Hematology Analyzer KX-21 Automated Hematology Analyzer Sysmex XN-9000 Automated Hematology Analyzer XE-5000 Automated Hematology Analyzer Automated Hematology Analyzer (XN-2000 V; XN-3000 Automated Hematology Analyzer Sysmex XT-4000i Automated Hematology Analyzer XP-300 Automated Hematology Analyzer XN-1000 AS-01 Automated Hematology Analyzer

35 protocols using automated hematology analyzer

Hematological Analysis of EDTA Blood

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Hematological results of EDTA-anticoagulant-treated peripheral blood were
analyzed by automated hematology analyzer (Sysmex, Japan), and hemoglobin
components and levels were performed by using capillary electrophoresis (CE;
Serbia, Paris, France).

Xian J., Wang Y., He J., Li S., He W., Ma X, & Li Q. (2022). Molecular Epidemiology and Hematologic Characterization of Thalassemia in Guangdong Province, Southern China. Clinical and Applied Thrombosis/Hemostasis, 28, 10760296221119807.

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Automated Hematological Hemoglobin Analysis

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Hemoglobin level of each blood sample in EDTA tube was determined using an automated hematological analyzer (Sysmex Automated Hematology Analyzer, Kobe, Japan, XP-300, model no.: AC580857).

Nsiah K., Bahaah B., Oppong Afranie B., Koffie S., Akowuah E, & Donkor S. (2019). Oxidative Stress and Hemoglobin Level of Complicated and Uncomplicated Malaria Cases among Children: A Cross-Sectional Study in Kumasi Metropolis, Ghana. Journal of Tropical Medicine, 2019, 8479076.

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Serum 25(OH)D and Immunological Biomarkers

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Measurements of serum 25(OH)D were performed by the enzyme-linked immunosorbent assay ELISA using DIAsource 25OH vitamin D Total ELISA kit (Louvain-la Neuve, Belgium). The analysis kit detection limit was defined as the apparent concentration two standard deviations below the average OD at zero binding was 1,5 ng/mL. Analysis of data was performed according to vitamin D content: deficiency < 20 ng/ml (< 50 nmol/L), insufficiency 20–30 ng / ml (50–75 nmol/L), normal amount 30–50 ng/ml (75–125 nmol/L) [34 –37 ].
Blood eosinophils evaluation was performed with an automated hematology analyzer (Sysmex, Kobe, Japan).
Measurements of total IgE level in serum were performed by ELISA using commercial test kit (ELISA, Bio-Clin-Inc., St. Louis, USA).

Bastyte D., Tamasauskiene L., Golubickaite I., Ugenskiene R, & Sitkauskiene B. (2023). Vitamin D receptor and vitamin D binding protein gene polymorphisms in patients with asthma: a pilot study. BMC Pulmonary Medicine, 23, 245.

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Serological and Biochemical Profiling for Liver Biopsy

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The routine laboratory tests were performed the day before liver biopsies. The serological markers of HBV were detected with ELISA kits (Abbott, Wiesbaden, Germany). The HBV DNA was quantified by real-time PCR (Applied Biosystems, Foster City, USA), with the detection limit 500 copies/ml. The parameters including ALT and AST were measured by automation biochemistry analyzer (Hitachi, Tokyo, Japan). Platelet count was detected with automated hematology analyzer (Sysmex, Kobe, Japan). The calculation formulas of APRI and FIB-4 as follows: (1) APRI= (AST/ULN of AST)/platelet count×100; (2) FIB-4= (age × AST)/ (platelet count × (ALT)^1/2).

Li Q., Lu C., Li W., Huang Y, & Chen L. (2017). Impact of age on the diagnostic performances and cut-offs of APRI and FIB-4 for significant fibrosis and cirrhosis in chronic hepatitis B. Oncotarget, 8(28), 45768-45776.

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Stroke Biomarkers and Outcomes

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The variables collected included demographics (age and gender), medical histories (hypertension, atrial fibrillation, diabetes, hyperlipidemia, and coronary heart diseases), the National Institute of Health Stroke Scale (NIHSS) score, the Alberta Stroke Program Early CT Score (ASPECTS), hemorrhagic transformation (30 (link)), reperfusion therapy method, and the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification (31 (link)). Successful recanalization after endovascular therapy was defined as a modified Thrombolysis in Cerebral Infarction grading system score of 2b or 3 (32 (link)). Blood samples were collected for laboratory measurements in the emergency department. White blood cell (WBC) counts, including absolute numbers of neutrophils were measured using an automated hematology analyzer (Sysmex, Kobe, Japan). Serum albumin levels were determined with an Olympus AU-5400 automatic analyzer (Olympus, Tokyo, Japan).

Cui T., Wang C., Zhu Q., Li S., Yang Y., Wang A., Zhang X., Shang W, & Wu B. (2022). Association between neutrophil percentage-to-albumin ratio and 3-month functional outcome in acute ischemic stroke patients with reperfusion therapy. Frontiers in Neurology, 13, 898226.

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Hematological Evaluation via Automated Analyzer

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Hematological parameters were determined with an automated hematology analyzer (Sysmex, Japan), and hemoglobin analysis was performed with either high-performance liquid chromatography (Bio-Rad, USA) or capillary electrophoresis (Sebia, France and Helena, USA).

Shang X., Peng Z., Ye Y., A.s.a.n., Zhang X., Chen Y., Zhu B., Cai W., Chen S., Cai R., Guo X., Zhang C., Zhou Y., Huang S., Liu Y., Chen B., Yan S., Chen Y., Ding H., Yin X., Wu L., He J., Huang D., He S., Yan T., Fan X., Zhou Y., Wei X., Zhao S., Cai D., Guo F., Zhang Q., Li Y., Zhang X., Lu H., Huang H., Guo J., Zhu F., Yuan Y., Zhang L., Liu N., Li Z., Jiang H., Zhang Q., Zhang Y., Juhari W.K., Hanafi S., Zhou W., Xiong F., Yang H., Wang J., Zilfalil B.A., Qi M., Yang Y., Yin Y., Mao M, & Xu X. (2017). Rapid Targeted Next-Generation Sequencing Platform for Molecular Screening and Clinical Genotyping in Subjects with Hemoglobinopathies. EBioMedicine, 23, 150-159.

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Routine Blood Test Protocol

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Peripheral venous blood samples were collected at the time of admission. Routine blood tests, including the counts of red and white blood cells (RBC and WBC), leukocyte subtypes, hematocrit (HCT), hemoglobin (Hb), and platelet (PLT), were performed using an automated hematology analyzer (Sysmex Corporation, Kobe, Japan).¹⁶ Collected laboratory data included PLT, LYM, and neutrophil counts (NEU), serum urea, creatinine (Cr) and albumin levels, erythrocyte sedimentation rate (ESR), and CRP.

Jafari M., Akbari M., Navidkia M., Dashtbin S., Mousavi S.F., Heidary M, & Khoshnood S. (2022). Comparison of clinical, radiological and laboratory findings in discharged and dead patients with COVID-19. Vacunas (English Edition), 23, S36-S43.

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Comprehensive Hematological and Cytokine Analysis

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A total of 24 clinical hematological parameters were determined using an Automated Hematology Analyzer (Sysmex, Tokyo, Japan). The serum levels of four cytokines, including interleukin-1β (IL-1β), IL-6, IL-10, and tumor necrosis factor-α (TNF-α), were quantified using enzyme-linked immunosorbent assay (ELISA) kits (Cat. No. ml037361; Cat. No. ml064292; Cat. No. ml037371; Cat. No. ml002859; Shanghai Enzyme-linked Biotechnology Co., Ltd., Shanghai, China). The assay was conducted on 6 biological replicates per treatment group, with each measurement repeated 3 times (technical replicates).

Xu H., You J., He W., Pei L., Han Y., Wang X., Tian Z., Zheng X., Wu E, & Ling Y. (2024). Dynamic changes in the migratory microbial components of colon tissue during different periods of sepsis in an LPS-induced rat model. Frontiers in Cellular and Infection Microbiology, 13, 1330087.

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Hematological Analysis of Mice

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At the end of the experiment (21 days), whole blood was obtained from the orbit of mice. Red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), white blood cell (WBC), platelet (PLT), and neutrophil (NEUT) were subsequently measured with an automated hematology analyzer (Sysmex, Shanghai, China). Criteria for HAPC diagnosis: HGB ≥ 210 g/L [27 (link)].

Liu X., Zhang H., Yan J., Li X., Li J., Hu J., Shang X, & Yang H. (2022). Deciphering the Efficacy and Mechanism of Astragalus membranaceus on High Altitude Polycythemia by Integrating Network Pharmacology and In Vivo Experiments. Nutrients, 14(23), 4968.

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Blood Sampling and Biochemical Analysis

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Blood samples were taken at the beginning of the study and at the end of the 3^rd month, following overnight fasting of at least 10 h, in the morning. A Sysmex automated hematology analyzer was used for the whole blood counts. HbA1c levels were determined by high-performance liquid chromatography with a TOSOH. Serum vitamin B12 level was studied with electrochemiluminescence immunoassay method (Beckman Coulter UniCel D×l 600).

Aydin B., Cansu G.B, & Ozlu C. (2022). Relationship between glycosylated hemoglobin and vitamin B12 deficiency anemia. Northern Clinics of Istanbul, 9(5), 459-463.

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