Birabresib

Manufactured by Selleck Chemicals

Birabresib is a laboratory instrument designed for scientific research purposes. It functions as a chemical compound used in various experimental and analytical applications.

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Lab products found in correlation

2 protocols using birabresib

Comparative Analysis of BET Inhibitors

Cited 3 times

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Apabetalone (RVX-208; BET inhibitor, S7295), ARV-825 (BRD4 specific inhibitor, S8297), AZD-5153 6-hydroxy-2-naphthoic acid (BET/BRD4 inhibitor, S8344), CPI-203 (BET inhibitor, S7304), Molibresib (I-BET-762; BET inhibitor, S7189), (+)-JQ1 (BET inhibitor, S7110), INCB054329 (BET inhibitor, S8753), MS436 (BET inhibitor, S7305), Birabresib (OTX015; BET inhibitor, S7360), PLX51107 (a new BET inhibitor, S8739), and PFI-1 (PF-6405761; BRD2/BRD4 inhibitor, S1216) were purchased from Selleck.cn, and ZL0580 (a BRD4-specific inhibitor) was prepared as previously described (20 (link), 45 (link)). The structures and functions of these inhibitors are shown in Fig. 3A, Text S1 in the supplemental material (see also Selleck.cn [https://www.selleck.cn]), and Table 1 (20 (link), 41 (link), 46 (link)– (link)55 (link)).

Zhao Y., Niu Q., Yang S., Yang J., Zhang Z., Geng S., Fan J., Liu Z., Guan G., Liu Z., Zhou J., Hu H., Luo J, & Yin H. (2022). Inhibition of BET Family Proteins Suppresses African Swine Fever Virus Infection. Microbiology Spectrum, 10(4), e02419-21.

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Small Molecule Drug Preparation Protocol

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Alisertib (10 mM, Selleckchem. #s1133), Birabresib (10 mM, Selleckchem. #s7360), Prexasertib (10 mM Selleckchem. #s6385), Mirdametinib (10 mM Selleckchem. #s1036), Panobinostat (10 mM Selleckchem. #s1030), Molibresib (10 mM Selleckchem. #s7189) and LY3295668 (10 mM Selleckchem. #s8782) were resuspended in dimethyl sulfoxide (DMSO, Sigma, #D5879). Stock solutions were stored at −20 °C. The solutions were diluted in culture medium extemporaneously for the experiments. All drugs used in our custom-made library were suspended in DMSO (Sigma, #D5879) and stock solutions were stored at −20 °C (Table S1 for details).

Ariey-Bonnet J., Berges R., Montero M.P., Mouysset B., Piris P., Muller K., Pinna G., Failes T.W., Arndt G.M., Morando P., Baeza-Kallee N., Colin C., Chinot O., Braguer D., Morelli X., André N., Carré M., Tabouret E., Figarella-Branger D., Le Grand M, & Pasquier E. (2023). Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms. eBioMedicine, 95, 104752.

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