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Zebra

Manufactured by IBA Dosimetry
Sourced in Germany

Zebra is a medical imaging system designed for radiotherapy treatment planning and verification. It provides accurate and reliable measurements of radiation doses delivered to patients during cancer treatment. The core function of Zebra is to capture and analyze data related to the delivery of radiation therapy, enabling healthcare professionals to optimize treatment plans and ensure patient safety.

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4 protocols using zebra

1

Proton Beam Dosimetry in Inhomogeneous Phantoms

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Among the two nozzles, a measurement was made in a multi-purpose nozzle with a wobbling beam of 190 MeV with a 5-cm ridge filter. Three categories of wobbling beam, according to field size, are available: small, medium, and large wobbling radius. The middle wobbling radius was selected for a 15-cm block diameter.
Reference data were obtained to verify the MC simulations and TPS calculations by measuring the rod-free area in the center of the Gammex phantom, where the proton beam passed through the 5-cm depth of the solid water material. A ZEBRA (IBA-Dosimetry, Schwarzenbruck, Germany) was used to measure the central axis of the beam. The PDDs of the eight different materials were measured using an OCTAVIUS Detector 729 Chamber Array (PTW, Freiburg, Germany) because the dose measurement passing through the inhomogeneity plug was off-axis and not feasible with ZEBRA. Hence, the two-dimensional absolute dose was measured by changing the thickness of the solid water phantom downstream of the Gammex phantom, with 1 mm intervals. After all measurements were completed, we constructed the PDD with a point dose at 1 mm depth increments along the central position of each rod.
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2

Proton Beam Characterization of Tissue Surrogates

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We used a 208 MeV proton spot and Zebra (IBA Dosimetry, Germany) to measure the RSP of lung, soft tissue, brain, and bone surrogates for the CIRS M701 adult male phantom since the material compositions of these tissue surrogate are identical for the CIRS anthropomorphic phantoms. The proton spot was delivered by Varian ProBeam System (Varian Medical Systems, Palo Alto) with a cyclotron current of 20 nA and the spot sigma of 3.79 mm at the ISO center. Figure 2 depicts the experiment setup. The beam ISO center was set at the phantom surface. The thickness of each phantom slab is 25 mm. The 80% distal range (R80) differences from the measurement with and without phantom slabs were used to compute the water equivalent thickness (WET). The Zebra measurement includes range uncertainty of ±0.5 mm . The measured RSP can be obtained using WET divided by the thickness of phantom slabs. Then we derived the reference mass density using Eq. (1) by adjusting material mass densities to match the measured RSP. The measured RSP values for lung, soft tissue, brain, and bone surrogates are 0.201, 1.040, 1.050, and 1.410, and the reference mass densities are 0.202, 1.054, 1.070, and 1.517 g/cm3, respectively.
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3

Monthly QA for Proton Therapy Delivery

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TG224 recommends four dosimetry tests for the monthly QA of US proton delivery.1 Tolerance for dose output, field flatness, and field symmetry is set at ±2% relative to the baseline, whereas tolerance for the distal range is ±1 mm.1 The monthly QA program at our center includes all four TG224 recommended parameters. Dose output is measured in water by placing a parallel‐plate (PPC05) ionization chamber (IBA Dosimetry, Schwarzenbruck, Germany) at the center of spread‐out Bragg peak (SOBP) for a proton beam that has a range (R) of 16 cm and modulation (M) of 10 cm (R16M10). The center of SOBP coincided with the isocenter. The snout position for dose output measurements was kept at 18 cm.
Field flatness and symmetry were acquired using IC Profiler (Sun Nuclear, Melbourne, FL, USA) in conjunction with the solid water for four different beams: R10M6, R16M10, R22M8, and R28M14. The detector plane was placed at the isocenter. For range measurements, the authors utilized a Zebra — a multilayer ionization chamber (MLIC) (IBA Dosimetry, Schwarzenbruck, Germany). The ranges were measured for R10, R16, R22, and R28. For both the range and profiles (flatness and symmetry) measurements, the snout was placed at 30 cm from the isocenter. For all dosimetry measurements, the aperture of 10‐cm‐circular diameter was utilized.
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4

Validating SPR from SECT Phantoms

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As a first experiment, SECT and SPR data sets of two phantoms were obtained. The phantoms used were the Advanced Electron Density Phantom (Sun Nuclear Corporation, Melbourne, FL, USA) and Model 062 Electron Density Reference Phantom (CIRS, Norfolk, VA, USA). For each phantom, both datasets were imported into the TPS and rigidly registered to each other. Each tissue‐equivalent insert was contoured on the SECT dataset and copied onto the SPR images. From the SECT dataset, the average CT number in HU within each tissue insert was obtained. The clinical CT‐number‐to‐mass‐density curve was used to convert this to an average mass density, which was then converted to an average SPR using data provided by RaySearch Laboratories. This workflow was meant to reproduce what happens within the TPS whenever SECT is used for proton therapy dose calculations. These values are then compared to the average SPR within the corresponding regions in the SPR data set as well as the SPR for each tissue surrogate plug. The latter was determined experimentally by sending a single beam of protons of two different energies (164.8 MeV and 227 MeV) through the long axis of each plug and measuring the distal 90% range of the exiting proton beam using a Zebra (IBA dosimetry GmbH, Schwarzenbruck, Germany) multi‐layer ion chamber (MLIC).
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