1 2 ethanedithiole

Rink-amide resin, protected amino acids, and solvents used for peptide synthesis were obtained from Protein Technologies Inc. (Tucson, AZ). Fluorescein isothiocyanate (FITC), trifluoroacetic acid, thioanisole, anisole, 1,2-ethanedithiole, methyl-tert-butyl ether, N,N-diisopropylethylamine, hydrazine, GSH, MA, and 3MA were purchased from Sigma-Aldrich (Saint-Louis, MO). Sulfosuccinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate (sulfo-SMCC) was obtained from Novachem (Calgary, Canada) and p-SNC-deferoxamine (DFO) was from Macrocyclics Inc. (Plato, TX). AlDoxorubicin was purchased from Medkoo Biosciences (Chapel Hill, NC). Doxorubicin was from LC Laboratories (Woburn, MA), and N2′- deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine was supplied by Carbosynth Ltd (Compton, WB). Uranyl formate was purchased from Electron Microscopy Sciences (Hatfield, PA), and 4′6-diaminidino-2-pheylindole (DAPI) and LysoTracker Red were purchased from Life Technologies Inc. (Norwalk, CT). Cyanine5.5 NHS ester was obtained from Lumiprobe Corporation (Hallandale Beach, FL) and luciferin was supplied by Caliper LifeSciences (Hopkinton, MA).

2(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate (HBTU) and the N-hydroxybenzotriazole (HOBt) were purchased from Vivitide (Gardner, MA). All protected amino acids, rink amide MBHA resin, and N-methylmorpholine (NMM) were supplied by Gyros Protein Technologies (Tucson, AZ). Polyethylene glycol (PEG₃) was obtained from Creative PEGWorks (Durham, NC). Trifluoroacetic acid (TFA), piperidine, thioanisole, anisole, 1,2-ethanedithiole, methyl-tert-butyl ether, N,N-diisopropylethylamine (DIPEA), dimethylformamide (DMF), acetonitrile (ACN), N-methyl-2-pyrrolidone (NMP), sodium carbonate, Sephadex G25, L-glutathione reduced (GSH), lipopolysaccharide (LPS), and cis-dichlorodiammine platinum (II) (cisplatin) were purchased from Sigma Aldrich (Saint-Louis, MO). Succinimidyl 3-(2-pyridyldithio)propionate (SPDP) was supplied by Invitrogen (Carlsbad, CA). p-SNC-deferoxamine (DFO) was from Macrocyclics Inc. (Plato, TX). N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)-maytansine (DM1) and aldoxorubicin HCl (aldox) were from MedKoo Biosciences (Morrisville, NC). Doxorubicin (DOX) and gemcitabine (GEM) were obtained from LC Laboratories (Woburn, MA). Mitomycin (MIT) was supplied by Selleckchem (Houston, TX). Cyanine5.5 NHS ester was purchased from Lumiprobe Corporation (Hallandale Beach, FL) and luciferin was from Caliper LifeScience (Hopkinton, MA).