Cymoxanil

Methanol HPLC Ultragradient Gold, formic acid 99% and ammonia solution 25% were purchased from Carlo Erba Reagents, SAS (Marseille, France). H₂O - Pierce™. Water, acetonitrile and formic acid LC-MS grade Optima^® were from Fisher Chemical (Hampton, NH, USA), state abbrev if USA, country). Caffeine-¹³C₃ (99%, 1 mg/mL in methanol) was obtained from Sigma-Aldrich (Schnelldorf, Germany). Standards (purity ≥97%) of all the chemicals listed (tert-butylazine; desethyl-tert-butylazine; dimethoate; atrazine; desethylatrazine; tebuconazole; alachlor; omethoate; bentazone; diuron; linuron; chlorotoluron; cymoxanil; thiamethoxam; clothianidin; imidacloprid; acetamiprid; thiacloprid; simazine; isoproturon; cybutryne; methiocarb; quinoxyfen; chlorpyrifos; 2,4D; MCPP; aclonifen; bifenox; MCPA; dichlorvos; bezafibrate; ibuprofen; amoxicillin·3H₂O; azithromycin; diclofenac; α-ethinylestradiol; β-estradiol; erythromycin; clarithromycin; trimethoprim; ciprofloxacin; enrofloxacin; sulfamethoxazole; bisoprolol; carbamazepine) were purchased from Sigma-Aldrich.

β-cyclodextrin (β-CD) was purchased from ACROS-Organics (MW = 1134.98 g·mol⁻¹, 98%, CAS 7585–39–9). For the poly(β-cyclodextrin) synthesis, hexamethylene diisocyanate (MW = 168.19 g·mol⁻¹, purity ≥ 98%, CAS 822–06–0, 1,6-HDI) and dibutyltin dilaurate (MW = 631.56 g·mol⁻¹, 95%, CAS 77–58–7, BTL) were supplied by Sigma-Aldrich (Steinhem, Germany). The N,N-dimethylformamide (DMF) used in the syntheses was dried by treatment with CaO (previously activated at 500 °C) for 24 h, followed by decanting and stirring with NaOH (solid) for 1 h. After further decantation, the solvent is distilled and stored over 4 Å molecular sieves. Activated carbon (AC, granular, pure) was purchased from Riedel-de Haën (Seelze, Germany). Cymoxanil (MW = 198.18 g·mol⁻¹, 98.9%, CAS 57966–95–7, CYM) and imidacloprid (MW = 255.66 g mol⁻¹, 100%, CAS 138261–41–3, IMD) were supplied by Sigma-Aldrich (Steinhem, Germany).
The other chemicals were used without further purification process. All solutions were prepared with Millipore-Q water obtained with gradient water purification system Direct-Q^® 3UV-R.