3t signa pet mr scanner

Five normal control volunteers (two male, three female, age 27.6 ± 2.0) and three patients (two male, one female, age 56.3 ± 8.4) with varying CNS lesions were recruited and scanned under IRB approval. Of the normal controls, four were scanned for the purposes of SNR comparison experiments described in Section 3.1.3 (two with ²H-Glc ingestion and two without). The normal control was scanned using the same DMI Protocol for Clinical Subjects as the three patients for clinical comparisons. Of the three patients, two had diseases which were considered well-managed at the time of imaging—one with an anaplastic oligodendroglioma, Grade III but without evidence of active disease (Patient A), and the second with a glioblastoma stable on an anti-VEGF drug for several months (Patient B). The third patient had an anaplastic cerebellar pilocytic astrocytoma behaving relatively aggressively (Patient C). All clinical subject information is summarized in Table 1.
Clinical subjects were scanned on a GE Signa 3T PET/MR scanner using a modified gradient filter (described in Section 2.1) and ²H volume RF coil (coil A in Section 2.2) approximately 45 min following the oral ingestion of 60 g of deuterated glucose ([6,6’-²H₂]Glc) as in Reference 37 using the pulse sequence described in Section 2.3 and the Imaging Protocol described in Algorithm 1.