Labrasol

Manufactured by Gattefosse

Sourced in France, India, United States, Germany, Canada, China

Labrasol is a non-ionic surfactant used in various pharmaceutical and cosmetic applications. It is a polyoxyethylene glycerol fatty acid ester that acts as a solubilizer, emulsifier, and wetting agent. Labrasol is designed to improve the solubility and bioavailability of active ingredients in formulations.

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Lab products found in correlation

Capryol 90, by Gattefosse (47 mentions) Labrafil m 1944 cs, by Gattefosse (27 mentions) Transcutol hp, by Gattefosse (27 mentions) Transcutol p, by Gattefosse (25 mentions) Tween 80, by Merck Group (20 mentions) Lauroglycol 90, by Gattefosse (18 mentions) Cremophor el, by BASF (16 mentions) Peceol, by Gattefosse (16 mentions) Tween 20, by Merck Group (15 mentions) Labrafil m 2125 cs, by Gattefosse (14 mentions) Labrafac pg, by Gattefosse (11 mentions) Cremophor rh40, by BASF (11 mentions) Lauroglycol fcc, by Gattefosse (10 mentions) Labrafac, by Gattefosse (10 mentions) Labrafil, by Gattefosse (9 mentions) Transcutol, by Gattefosse (9 mentions) Compritol 888 ato, by Gattefosse (9 mentions) Acetonitrile, by Merck Group (9 mentions) Solutol hs 15, by BASF (8 mentions) Poloxamer 188, by Merck Group (8 mentions)

Spelling variants of this product

Labrasol ALF (7 citations) Caprylocaproyl macrogol-8-glycerides (Labrasol), (3 citations) PEG-8 caprylic/capric glycerides (Labrasol) (2 citations)

121 protocols using labrasol

Formulation and Characterization of Fenugreek SEDDS

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Isopropyl myristate was purchased from Merck (Darmstadt, Germany). Transcutol HP, Labrasol, Kolliphor RH40 and Capryol 90 were obtained from Gattefossé (Saint-Priest, France).
We formulated 5 different compositions of the liquid extract, the SEDDS excipients and PBS, as displayed on Table 3.
The various amounts of isopropyl miristate, Transcutol HP, Labrasol, Kolliphor RH40 and Capryol 90 were mixed well in a plastic tube. Concentrated liquid fenugreek extract or PBS was added, then the mixture was mixed with gentle vortexing until we achieved a visually homogenous appearance. All the experiments were performed immediately after preparation.

Sinka D., Doma E., Szendi N., Páll J., Kósa D., Pető Á., Fehér P., Ujhelyi Z., Fenyvesi F., Váradi J., Vecsernyés M., Szűcs Z., Gonda S., Cziáky Z., Kiss-Szikszai A., Vasas G, & Bácskay I. (2022). Formulation, Characterization and Permeability Studies of Fenugreek (Trigonella foenum-graecum) Containing Self-Emulsifying Drug Delivery System (SEDDS). Molecules, 27(9), 2846.

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Topical Formulation Development for CBD/CBG/THCV

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CBD and CBG were obtained from Purisys (GA, USA). THCV was obtained from Open books (NC, USA). N-Methyl-2-pyrrolidone (NMP), Dimethyl sulfoxide (DMSO), Polyethylene glycol (PEG) 400, λ-Carrageenan (plant-mucopolysaccharide) and Oleic acid were purchased from Sigma-Aldrich (USA). Lactic Acid was purchased from Merck (Kenilworth, NJ). Hydroxyethyl cellulose (H.E.C.) was purchased from The Dow Chemical Company (Midland, MI). Isopropyl myristate (IPM), Ethyl Oleate and Polyoxyethylene Oleyl Ether were gifts from Croda (Edison, NJ). Transcutol P, Labrasol and Labrafil were gifts from Gattefossé (France).

Salau O., Bagde A., Kalvala A, & Singh M. (2022). Enhancement of transdermal permeation of cannabinoids and their pharmacodynamic evaluation in rats. International journal of pharmaceutics, 624, 122016.

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Insulin-Chitosan Nanoparticle Formulation

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Recombinant human insulin powder was purchased from Biocon, Bangalore, India. Low molecular weight chitosan was prepared by acidic depolymerization of high molecular weight chitosan (Xiamen Xing, Shanghai, China) via acid hydrolysis to produce low molecular weight chitosan (13 kDa and DDA 99%). The method of preparation was conducted according to previously published work [18 (link)]. Oleic acid was obtained from Merck, Darmstadt, Germany. Plurol oleique^® (polyglyceryl-6-dioleate) and Labrasol^® (PEG 8 caprylic/capric glycerides) were purchased from Gattefosse, Saint Priest, France. Strepotozotocin and Pepsin were obtained from Sigma-Aldrich, St. Louis, MO, USA.

Elsayed A.M., Khaled A.H., Al Remawi M.M., Qinna N.A., Abu Farsakh H, & Badwan A.A. (2018). Low Molecular Weight Chitosan-Insulin Complexes Solubilized in a Mixture of Self-Assembled Labrosol and Plurol Oleaque and Their Glucose Reduction Activity in Rats. Marine Drugs, 16(1), 32.

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Formulation and Characterization of Ellagic Acid Nanoparticles

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Ellagic acid was purchased from Sigma-Aldrich. Miglyol 812N (tricaprylin; C8/C10 fatty acid triglycerides; caprylic/capric triglycerides; 1,2,3-propanetriyl ester caprylic acid; caprylic acid, 1,2,3-propanetriyl ester; glycerol trioctanoate; glyceryl tricaprylate; octanoic acid, 1,2,3propanetriyl ester) was a gift of Cremer Oleo Division (Witten, Germany). Labrasol^® (caprylocaproyl macrogol-8 glyceride; PEG-8 caprylic/capric glycerides) was purchased form Gattefossé (Saint-Priest, France). Tristearin (Propane-1,2,3-triyltrioctadecanoate; 1,3-Di(octadecanoyloxy)propan-2-yloctadecanoate; stearic triglyceride; glyceryl stearate), poloxamer 188 (methyl-oxirane polymer, 75:30), and all other solvents and materials were provided by Merck (Milano, Italy).

Singh Hallan S., Sguizzato M., Pavoni G., Baldisserotto A., Drechsler M., Mariani P., Esposito E, & Cortesi R. (2020). Ellagic Acid Containing Nanostructured Lipid Carriers for Topical Application: A Preliminary Study. Molecules, 25(6), 1449.

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Topical Nanoemulsion Formulation Development

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PV was obtained as a gift sample from Qingdao Sigma Chemical Co., Ltd. Shandong, China. Basil oil, thyme oil, peppermint oil, rosemary oil, LO, citronella oil, verbena oil, and camphor oil were procured from Jiangxi Origin Aromatics Co., Ltd. Jiangxi, China. Tween80, Span80, Steareth-2, Steareth-21, Labrasol, Labrafil 1944, Brij 30, Lauroglycol-FCC, Lutrol-E400, propylene glycol, and Transcutol were obtained as gift samples from Gattefosse (Saint-Priest, France).

Hosny K.M., Sindi A.M., Alkhalidi H.M., Kurakula M., Alruwaili N.K., Alhakamy N.A., Abualsunun W.A., Bakhaidar R.B., Bahmdan R.H., Rizg W.Y., Ali S.A., Abdulaal W.H., Nassar M.S., Alsuabeyl M.S., Alghaith A.F, & Alshehri S. (2021). Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis. Drug Delivery, 28(1), 1043-1054.

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Formulation and Evaluation of Enzalutamide Soft Capsules

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ENZ was purchased from MSN Labratories Private Ltd. (Telangana, India). The Xtandi^® soft capsule, TPGS and MCT oil were supplied by Boryung Corporation (Seoul, Republic of Korea). Labrafac PG, Peceol, Labrasol, Capryol 90, Transcutol P, and Lauroglycol 90 were obtained from Gattefosse (St. Priest, France). Cremophor EL, Cremophor RH60, and Solutol HS15 were supplied by BASF (Ludwigshafen, Germany). Castor oil, coconut oil, olive oil, sesame oil, sunflower oil, corn oil, soybean oil, cotton seed oil, peanut oil, polysorbate 80, ammonium acetate, acetone, and acetonitrile were purchased from Daejung Co. Ltd. (Siheung, Republic of Korea). Sodium carboxymethyl cellulose was purchased from Duksan Pure Chemical (Ansan, Republic of Korea). All other chemicals used were of analytical grade.

Lee S.M., Lee J.G., Yun T.H., Cho J.H, & Kim K.S. (2024). Enhanced Stability and Improved Oral Absorption of Enzalutamide with Self-Nanoemulsifying Drug Delivery System. International Journal of Molecular Sciences, 25(2), 1197.

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Lipid-Based Formulations Composition

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Capryol 90 (propylene glycol caprylate), Labrasol (PEG-8 caprylic/capric glycerides), Labrafil M 1944 CS (mono-, di-, and triglycerides and PEG-6 mono- and diesters of oleic acid), Labrafac lipophile WL 1349 (triglycerides of caprylic and capric acids), and Peceol (glyceryl monooleate) were purchased from Gattefosse (Saint-Priest, France). Capmul MCM (mono-diglyceride of caprylic and capric acid) and Capmul PG-12 (propylene glycol monolaurate) were supplied by Abitec Corporation (Columbus, OH). Glyceryl trioleate, Kolliphor RH40 (polyoxyl 40 hydrogenated castor oil), Span 80 (sorbitan monooleate), Span 85 (sorbitan trioleate), plumbagin, and other chemicals were supplied by Sigma (St. Louis, MO).

Chrastina A., Welsh J., Borgström P, & Baron V.T. (2022). Propylene Glycol Caprylate-Based Nanoemulsion Formulation of Plumbagin: Development and Characterization of Anticancer Activity. BioMed Research International, 2022, 3549061.

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Prostate Cancer Cell Line and PDX Cultivation

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LNCaP and C4–2 were purchased from ATCC (ATCC.com). LAPC4 and LREX were provided by Dr. Sawyers, Memorial Sloan Kettering Cancer Center. LNCaP, C4–2, 22Rv1 and LREX cells were cultured in RPMI1640+GlutaMAX (Gibco, Life Technologies), 10% FBS (Gibco, Life Technologies), 1% Penicillin/Streptomycin (Corning). LAPC4 cells were cultured in IMDM supplemented with 10% FBS and 1% Penicillin/Streptomycin. For androgen deprivation in vitro studies, 10% charcoal stripped serum (CSS) (Gibco, Life Technologies) was used in place of 10% FBS. All cell lines were tested for mycoplasma contamination (PCR Mycoplasma Detection; primer sequence in Supplementary Table 1) every 6 months. LuCaP PDX models (provided by Dr. E. Corey and Dr. R. Vessella, Washington University) were grown in organoid culture in advanced DMEM/F12 media with supplements, as previously published (18 (link)). For in vitro studies, ipatasertib (Chemietek) and enzalutamide (Selleckchem) were dissolved in DMSO. CellTitre Glo Assay (Promega) was used to assess cell viability. For in vivo studies, ipatasertib (Division of Cancer Treatment and Diagnosis, NCI Developmental Therapeutics Program) and enzalutamide (DCTD, NCI DTP) were dissolved in 1:1 of labrasol (Gattefosse) to PEG400 (Sigma).

Adelaiye-Ogala R., Gryder B.E., Nguyen Y.T., Alilin A.N., Grayson A.R., Bajwa W., Jansson K.H., Beshiri M.L., Agarwal S., Rodriguez-Nieves J.A., Capaldo B., Kelly K, & VanderWeele D.J. (2020). Targeting the PI3K/AKT pathway overcomes enzalutamide resistance by inhibiting induction of the glucocorticoid receptor. Molecular cancer therapeutics, 19(7), 1436-1447.

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Ibuprofen Formulation Development and Characterization

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Ibuprofen as the model drug was obtained from Baike Pharmaceutical Co. Ltd. (Beijing, China). Excipients such as Labrafac Lipophile WL1349, Labrafil M 1944 CS, Labrasol and Transcutol P were donated by Gattefosse (Shanghai, China). Cremophor RH40 was purchased from Xietai Chemical Co. Ltd. (Shanghai, China). Tween 80, oleic acid, ethanol and propylene glycol were obtained from Meilin Industry and Trade Co. Ltd. (Tianjin, China). Acetonitrile and methanol were HPLC grade and supplied from Kemiou Chemical (Tianjin, China). Other chemicals and solvents were analytical grade.

Hu L., Hu Q, & Yang J. (2014). Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle. Iranian Journal of Basic Medical Sciences, 17(10), 760-766.

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Phospholipid-based Diuretic Formulation

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Phospholipon^®90G (Phospholipid GmbH, Koln, Germany), HCTZ (Juhel Pharmaceuticals, Nigeria), Labrasol^® (Gattefosse, France), Irvingia fat was prepared in Department of Pharmaceutical Technology and Industrial Pharmacy Laboratory, University of Nigeria, Nsukka, Nigeria.

Agubata C.O., Chime S.A., Kenechukwu F.C., Nzekwe I.T, & Onunkwo G.C. (2014). Formulation and characterization of hydrochlorothiazide solid lipid microparticles based on lipid matrices of Irvingia fat. International Journal of Pharmaceutical Investigation, 4(4), 189-194.

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