Shrews were habituated to IP injections and to clear plastic observation chambers (23.5 × 15.25 × 17.8 cm) for two consecutive days prior to experimentation. Two hours before dark-onset, the animals were injected IP with native OT (50 μg/kg, 100 μg/kg, 500 μg/kg, 5mg/kg or 0.05, 0.1, 0.5, and 5 μmol/kg respectively), OT-B12 (143 μg/kg, 286 μg/kg, 1.4 mg/kg, 14.3 mg/kg or 0.05, 0.1, 0.5, and 5 μmol/kg respectively) or saline, then video-recorded (Vixia HF-R62, Canon) for 120 minutes. After 120 min, the animals were returned to their cages. Treatments were separated by 3 days. Analysis of emetic episodes were measured by an observer blinded to treatment groups. Emetic episodes were characterized by strong rhythmic abdominal contractions associated with either oral expulsion from the gastrointestinal tract (i.e., vomiting) or without explusion of materials (i.e., retching). Latency to the first emetic episode, total number of emetic episodes and number of emetic episodes per minute were quantified as previously described 21 ,22 ,32 (link).
Vixia hf r62
Manufactured by Canon
The Canon Vixia HF-R62 is a high-definition camcorder with a 57x advanced zoom lens, 1/4.85-inch CMOS sensor, and 3.28-megapixel image capture. It records in 1080p full HD resolution and supports various video formats, including MP4 and AVCHD.
Automatically generated - may contain errors
Lab products found in correlation
10 protocols using vixia hf r62
1
Oxytocin-Induced Emetic Responses in Shrews
2
Exendin-4 and Emetic Responses
3
Emetic Responses in Shrews
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Shrews (male;
∼6 months old; 60–70 g; n = 8 per group)
were habituated to IP injections and to clear plastic observation
chambers (23.5 × 15.25 × 17.8 cm) for two consecutive days
prior to experimentation. The animals were injected IP with GEP44
(10 or 60 nmol/kg), Ex-4 (5 nmol/kg) or vehicle, then video-recorded
(Vixia HF-R62, Canon) for 120 min. After 120 min, the animals were
returned to their cages. Treatments were separated by 72 h, and treatment
order was determined using a randomized complete block design. Analysis
of emetic episodes were measured by an observer blinded to treatment
groups. Emetic episodes were characterized by strong rhythmic abdominal
contractions associated with either oral expulsion from the gastrointestinal
tract (i.e., vomiting) or without the passage of materials (i.e.,
retching).
∼6 months old; 60–70 g; n = 8 per group)
were habituated to IP injections and to clear plastic observation
chambers (23.5 × 15.25 × 17.8 cm) for two consecutive days
prior to experimentation. The animals were injected IP with GEP44
(10 or 60 nmol/kg), Ex-4 (5 nmol/kg) or vehicle, then video-recorded
(Vixia HF-R62, Canon) for 120 min. After 120 min, the animals were
returned to their cages. Treatments were separated by 72 h, and treatment
order was determined using a randomized complete block design. Analysis
of emetic episodes were measured by an observer blinded to treatment
groups. Emetic episodes were characterized by strong rhythmic abdominal
contractions associated with either oral expulsion from the gastrointestinal
tract (i.e., vomiting) or without the passage of materials (i.e.,
retching).
4
Emetic Episode Analysis in Shrews
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Shrews (n = 48) were habituated to the experimental conditions as described above. The animals were pre-treated with GIP-085 (300 nmol/kg, IP) or vehicle 1 h prior to cisplatin (30 mg/kg, IP) or saline injection. Animals were video-recorded (Vixia HF-R62, Canon) for 180 min. After 180 min, the animals were returned to their cages. Emetic episodes were analyzed by an observer blinded to treatment groups. Emetic episodes were characterized by strong rhythmic abdominal contractions associated with either oral expulsion from the gastrointestinal tract (i.e. vomiting) or without the passage of materials (i.e. retching). Latency to the first emetic episode, total number of emetic episodes, number of emetic episodes per minute and per 20-minute intervals were quantified.
5
Emetic Effects of Oxytocin and Vitamin B12
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Shrews were habituated to IP injections and to clear plastic observation chambers (23.5 × 15.25 × 17.8 cm) for two consecutive days before experimentation. Two hours before dark‐onset, the animals were injected IP with native OT (50 μg/kg, 100 μg/kg, 500 μg/kg, 5 mg/kg or 0.05, 0.1, 0.5 and 5 μmol/kg, respectively), OT‐B12 (143 μg/kg, 286 μg/kg, 1.4 mg/kg, 14.3 mg/kg or 0.05, 0.1, 0.5 and 5 μmol/kg, respectively) or saline, then video‐recorded (Vixia HF‐R62; Canon) for 120 min. After 120 min, the animals were returned to their cages. Treatments were separated by 3 days. Analysis of emetic episodes were measured by an observer blinded to treatment groups. Emetic episodes were characterized by strong rhythmic abdominal contractions associated with either oral expulsion from the gastrointestinal tract (i.e. vomiting) or without expulsion of materials (i.e. retching). Latency to the first emetic episode, total number of emetic episodes and number of emetic episodes per minute were quantified as previously described.21 , 22 , 32
6
Shrews' Responses to Peptide Injections
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Shrews (n = 23) were habituated to i.p. injections and to clear plastic observation chambers (23.5 × 15.25 × 17.8 cm) for two consecutive days prior to experimentation. Two hours before dark-onset, the animals were injected i.p. with sCT (5 and 50 μg/kg), amylin (500 and 5000 μg/kg), or saline, then video-recorded (Vixia HF-R62, Canon) for 120 min. After 120 min, the animals were returned to their cages. In a sub-group of animals (n = 13) food intake was measured at 6, 24, 48, and 72 h post-injection as previously described [48 (link)]. Body weights were taken at 0, 24, 48, and 72 h. Treatments occurred in a within-subject, counter-balanced design and were 7 days apart.
At the end of the experiment, a subgroup of animals (n = 10) was injected with the GLP-1R agonist Exendin-4 (Ex4, 30 μg/kg i.p.) or saline. Emetic episodes, food intake, and body weight were measured as described above. Treatments occurred in a within-subject, counter-balanced design and were 7 days apart.
At the end of the experiment, a subgroup of animals (n = 10) was injected with the GLP-1R agonist Exendin-4 (Ex4, 30 μg/kg i.p.) or saline. Emetic episodes, food intake, and body weight were measured as described above. Treatments occurred in a within-subject, counter-balanced design and were 7 days apart.
7
Emetic Responses to Ex4 in Shrews
8
Emetic Effects of Neuropeptide Agonists
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Shrews (n = 10) were habituated
to IP injections and to clear plastic observation chambers (23.5 ×
15.25 × 17.8 cm) for four consecutive days prior to experimentation.
The animals were injected IP with nEx4,1 , 22 (all at 5 nmol/kg), or vehicle, placed in their respective emetic
cages, and then video-recorded (Vixia HF-R62, Canon) for 120 min.
All recordings started within 2 min after drug administration. After
120 min, the animals were returned to their cages. Treatments were
separated by 72 h. Analysis of emetic episodes was performed by an
observer blinded to treatment groups. Emetic episodes were characterized
by strong rhythmic abdominal contractions associated with either oral
expulsion from the gastrointestinal tract (vomiting) or without the
passage of materials (retching). Latency to the first emetic episode,
the total number of emetic episodes, and the number of emetic episodes
per minute were recorded.
to IP injections and to clear plastic observation chambers (23.5 ×
15.25 × 17.8 cm) for four consecutive days prior to experimentation.
The animals were injected IP with nEx4,
cages, and then video-recorded (Vixia HF-R62, Canon) for 120 min.
All recordings started within 2 min after drug administration. After
120 min, the animals were returned to their cages. Treatments were
separated by 72 h. Analysis of emetic episodes was performed by an
observer blinded to treatment groups. Emetic episodes were characterized
by strong rhythmic abdominal contractions associated with either oral
expulsion from the gastrointestinal tract (vomiting) or without the
passage of materials (retching). Latency to the first emetic episode,
the total number of emetic episodes, and the number of emetic episodes
per minute were recorded.
9
Emetic Effects of GEP44 and Ex-4 in Shrews
10
Antiemetic Effects of Ex4 and Cbi-Ex4
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