Magnetom trio tim syngo

Anatomical MRI was performed at the Unité de Neuroimagerie Fonctionelle (UNF) du Center de Recherche de l'Institut Universitaire de Gériatrie de Montréal (CRIUGM). Brain imaging was done with a 3.0T Siemens MAGNETOM Trio TIM Syngo magnetic resonance imaging (MRI) scanner (Siemens, Erlangen, Germany), with a 12-channel head coil. For each participant, we obtained a 3D, T1-weighted Magnetization Prepared Rapid Gradient Echo [MPRAGE] sequence (TR/TE/TI = 2300/2.98/900 ms) (voxel size = 1 × 1 × 1 mm³; sagittal acquisition; 176 slices; 256 × 256 mm grid). The raw images underwent automated correction for intensity non-uniformity and normalization for signal intensity (Sled et al., 1998 (link)).

Functional and anatomical images were collected using a 3T Siemens Magnetom Trio Timsyngo MR system, with a 12-channel head coil in the State Key Laboratory of Cognitive Neuroscience and Learning of Beijing Normal University. Functional images were collected using a gradient-recalled-echo echo-planar imaging (EPI) sequence sensitive to the BOLD signal. Forty-one axial slices were collected with the following parameters: TR = 2500 ms, TE = 30 ms, flip angle = 90°, FOV = 20 cm, matrix = 64 × 64, 3 mm thickness, yielding a voxel size of 3.125 mm × 3.125 mm × 3 mm, interleaved slices with no gap. The LD task was accomplished in two runs of 332 volumes (13 m, 50 s) including four TRs of rest at the beginning and end of each run.
Following the acquisition of functional data, high resolution T1-weighted anatomical reference images were obtained using a 3D magnetization prepared rapid acquisition gradient echo (MPRAGE) sequence, TR = 2530 ms, TE = 3.45 ms, flip angle = 7°, FoV = 25.6 cm, matrix = 256 × 256 with 1 mm thick sagittal slices.

Intact human brain hemispheres from 19 patients with definite CAA^{20 (link)} and 5 non-CAA control cases were included from an ongoing post-mortem MRI study at MGH. Details on the inclusion process, scanning procedures and tissue block sampling have been described previously.^{8 (link),30 (link)} In short, the hemispheres were fixed in 10% formalin for several weeks after autopsy. Prior to ex vivo 3T MRI, the hemispheres were placed in a plastic bag filled with periodate-lysine-paraformaldehyde and vacuum sealed. The samples were scanned overnight on a 3T MR system (Siemens, Magnetom trioTim syngo) using a 32-channel head coil. The protocol included a T₂-weighted turbo-spin echo sequence (TR, 1800 ms; TE, 61 ms; voxel size, 500 μm³ isotropic) and a gradient-echo fast low-angle shot (FLASH) sequence (TR, 20 ms; voxel size, 500 μm³ isotropic). Presumed ischaemic and haemorrhagic CC lesions were identified by the same raters (W.M.F. and S.J.v.V.) who were blinded to CAA severity or other histopathological findings. Inter-rater reliability for the presence of CC lesions was substantial [κ (95% CI) = 0.75 (0.48–1)].

Anatomical magnetic resonance imaging (MRI) was performed at the Unité de Neuroimagerie Fonctionnelle (UNF) du Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal (CRIUGM) on a 3.0T Siemens MAGNETOM Trio TIM Syngo (Siemens, Erlangen, Germany), with a 12-channel head coil. A total of 65 children underwent a three-dimensional, high-resolution, whole brain, structural T1-weighted magnetization-prepared gradient-echo image (MP-RAGE) sequence; TR = 2,300 ms, TE = 2.98 ms, TI = 900 ms; 256 mm field of view, 1 mm slice thickness, 176 slices, sagittal acquisition, time = 9 min. For this study, only 53 children’s data were analyzed, as rest of 12 children had no genetic data.